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Thiol-polyethylene glycol modified magneto-optical composite nano-material and its application

A technology of mercapto polyethylene glycol and composite nanomaterials, which can be used in medical preparations containing active ingredients, wave energy or particle radiation treatment materials, preparations for in vivo experiments, etc. Side effects and other problems, to achieve the effect of simple preparation method, excellent magnetic properties, good water solubility

Inactive Publication Date: 2012-04-11
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In addition, in the prior art, the main treatment methods for cancer include surgery, chemotherapy and radiotherapy, all of which have their own limitations: surgery is often difficult to completely remove all cancer cells in the body, especially when cancer cells metastasize Difficult; both chemotherapy and radiotherapy poison cancer cells with no difference or little difference from normal cells, have great toxic side effects and may induce drug resistance of cancer cells

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  • Thiol-polyethylene glycol modified magneto-optical composite nano-material and its application
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  • Thiol-polyethylene glycol modified magneto-optical composite nano-material and its application

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Embodiment 1

[0048] like figure 1 As shown, the preparation of UCNP-based optomagnetic composite nanomaterials (MFNP) specifically includes the following steps:

[0049] (1) Using yttrium oxide, ytterbium oxide, and erbium oxide as starting materials, they are converted into corresponding trifluoroacetic acid salts under the action of trifluoroacetic acid, and then synthesized up-conversion nanocrystals (UCNP) by high-temperature thermal decomposition , the specific steps are: in a 50ml three-necked flask, add 1 mmol of trifluoroacetate according to the molar ratio of Y:Yb:Er=78:20:2, add 2 mmol of sodium trifluoroacetate, and then add 20 ml of oil acid and 20ml carbadecene. Under the protection of nitrogen, it was first heated to 140°C for 1 hour, then slowly raised to 320°C for 1 hour, and the whole process was always protected by nitrogen. After the reaction, cool to 80°C and add 50 ml of ethanol, centrifuge and wash four times with cyclohexane and ethanol, and finally disperse in 5...

Embodiment 2

[0061] Up-conversion luminescence imaging and magnetic resonance imaging tests of mercaptopolyethylene glycol-modified MFNP: LA-PEG-modified MFNP was diluted sequentially from high to low into different concentration gradients (0.32 mg / L, 0.128 mg / L, 0.064 mg / L, 0.032mg / L, 0.0064mg / L), the up-conversion luminescence imaging was measured on the small animal imaging system (CRI), and the magnetic resonance contrast imaging was measured on the magnetic resonance imaging system (Bruker).

[0062] The result is as Figure 6 As shown, as the concentration of LA-PEG-modified MFNP gradually increases, the up-conversion luminescence signal becomes stronger, while the MRI image becomes darker. By measuring its T 2 The value changes in a linear relationship and can be used as an MRI contrast reagent. And by comparison, the sensitivity of up-conversion luminescence imaging is higher than that of magnetic resonance imaging, and the latter has a strong penetrating ability, which can provi...

Embodiment 3

[0064] The heating curve test of mercaptopolyethylene glycol modified MFNP under laser irradiation: 2 ml LA-PEG modified MFNP (1mg / ml) solution was placed in a cuvette, 808 nm laser (power 1W / cm 2 ) is directly irradiated on the sample, the distance between the laser head and the sample is 7 cm, and the temperature change curve is measured by a temperature detector.

[0065] The result is as Figure 7 As shown, within 5 minutes, the temperature of 1 mg / ml LA-PEG modified MFNP rapidly increased from room temperature 25 degrees to 48 degrees under laser irradiation, while the temperature of the water in the control group basically did not change. Such relatively strong optical absorption properties can be used as materials for photothermal therapy.

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Abstract

The invention discloses a thiol-polyethylene glycol modified magneto-optical composite nano-material and its application. An up-conversion nano material is taken as a basal layer, the surface of the basal layer is provided with a polyacrylic acid layer, the surface of the polypropylene layer is provided with a layer of dopamine modified ferriferrous oxide magnetic particles, a golden shell layer is covered on the dopamine modified ferriferrous oxide magnetic particles layer, and the thioctic acid modified polyethylene glycol is provided on the golden shell layer; the thiol-polyethylene glycolmodified magneto-optical composite nano-material has guidance functions of up-conversion imaging and magnetic resonance imaging dual imaging, under the physical induction action of the magnetic field, the nano-material of the invention enables magnetic targeting to the specific position, so that the distribution in other internal organs can be reduced, and the damage in other internal organs during the treatment process is reduced. The nano-material can be taken as a good reagent for photo-thermal treatment by using the strong absorption property on the surface. The magnetic targeting photo-thermal treatment is combined under the imaging guidance, thereby the composite nano-material of the invention plays an important effect in clinical medical science and biological technology in future.

Description

technical field [0001] The invention relates to a composite material based on an upconversion nanometer material and the application of the composite material in the preparation of a magnetic resonance contrast agent or a photothermal therapy drug under imaging guidance and magnetic targeting. Background technique [0002] Cancer is one of several major malignant diseases that threaten human health in the 21st century. Although a large amount of human, material and financial resources have been invested in the prevention and treatment of cancer for decades since the 1950s, the progress made by human beings in this regard is still very limited. [0003] Due to their unique size and physicochemical properties, nanomaterials have great application potential in cancer imaging and treatment. On the one hand, many inorganic nanomaterials have optical, magnetic, acoustic and other physical properties that can be used for biomedical imaging. Optical nanomaterials such as classical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/12A61K41/00
Inventor 刘庄程亮
Owner SUZHOU UNIV
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