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154 results about "Type antigen" patented technology
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While it is attached, the antibody creates a chemical reaction that will eventually lead to the destruction of the antigen. The blood factors are human antigens that determine a person's blood type. A antigen is a protein which is present on the surface of red blood cells.
Carbohydrate encapsulated nanoparticles
The present invention provides carbohydrate encapsulated nanoparticles. In particular, the present invention provides metallic nanoparticles (e.g. gold nanoparticles) that are encapsulated in biologically important carbohydrate molecules, such as sugars, sugar derivatives, P-blood group antigens and analogues thereof. The present invention also provides methods of employing these carbohydrate encapsulated nanoparticles in diagnostic and therapeutic applications.
Owner:ACAD SINIC +2
Human erythrocyte membrane antigen coated microsphere and application thereof
InactiveCN101957366AMaintain and preserve antigenic activityLong validity periodBiological testingAntiendomysial antibodiesMicrosphere
The invention provides a method for preserving the activity of a human cell membrane blood group antigen, which comprises the steps of: preparing an erythrocyte membrane blood group antigen extract, and then coating the prepared erythrocyte membrane blood group antigen on a solid microsphere so as to replace a fresh erythrocyte to be used for detecting a blood group antibody in a sample.
Owner:INTEC PROD INC
Reverse typing colloidal gold kit for ABO blood groups and preparation method thereof
ActiveCN103033632AShort validity periodLow costBiological testingGroup A - bloodBlood group antigens
The invention discloses a reverse typing colloidal gold kit for ABO blood groups and a preparation method thereof. The reverse typing colloidal gold kit for the ABO blood groups comprises a reacting plate, erythrocyte membrane antigen gold particles and a basic solution, wherein 3N reaction holes are formed in the reacting plate and are respectively used for placing A erythrocyte membrane antigen gold particles and a basic solution, B erythrocyte membrane antigen gold particles and a basic solution, and O erythrocyte membrane antigen gold particles and a basic solution; the reaction holes are of circular structures, the bottoms of the holes are smooth and U-shaped; and sealing covers are arranged on the reaction holes. The kit also can be a dry kit; and the erythrocyte membrane antigen gold particles and the basic solution are dried on the reaction holes. According to the reverse typing colloidal gold kit for the ABO blood groups and the preparation method, erythrocyte membrane blood group antigen extracts are prepared and then marked with the colloid gold, and thereby the problem that the fresh erythrocyte just can be stored in a short period can be solved. The kit has the shelf life not less than 12 months at 2 to 20 DEG C, and has the advantages of being high in sensitivity, convenient to use, and relatively low in cost, and identifying the results easily.
Owner:INTEC PROD INC
Novel influenza m2 vaccines
The present invention includes novel influenza antigenic formulations and vaccines that comprise influenza M2 peptide and VLPs comprising influenza M2 protein. The invention also includes methods of making and administering the novel antigenic formulation and vaccine. The invention also include methods of inducing immunity to ameliorate and / or prevent influenza infections in a subject.
Owner:NOVAVAX
Detection kit and application thereof
The invention provides a detection kit containing two anti-porcine circovirus 2 type monoclonal antibodies, two anti-classical swine fever virus monoclonal antibodies and / or two anti-highly pathogenic porcine reproductive and respiratory syndrome virus monoclonal antibodies; the kit can be applied for simultaneous detection of a porcine circovirus 2 type antigen, a classical swine fever virus antigen and / or a highly pathogenic porcine reproductive and respiratory syndrome virus antigen with non-diagnostic purpose, moreover, the detection sensitivity of the kit for simultaneous detection of two or three kinds of viruses is higher than that for the detection of single virus, and false positive results are avoided.
Owner:LUOYANG PULIKE WANTAI BIOTECH
Method for detecting valence of antibody
InactiveCN103439515AImprove linearityEasy accessCarrier-bound/immobilised peptidesBiological testingAntiendomysial antibodiesMicrosphere
The invention discloses a method for detecting the valence of an antibody. The method comprises the following steps: 1), coupling an antigen on a microsphere to obtain a modified microsphere; 2), mixing and reacting the modified microsphere with an antibody solution; 3), measuring the turbidity of the reaction liquid, so as to determine the valence of the antibody. According to the method provided by the invention, CCP is modified on the surface of a polystyrene microsphere by adopting a vitamin H-streptavidin system, so as to prepare a granular CCP antigen successfully; in case that the granular CCP antigen prepared by adopting the method is used for detecting the valence of anti-CCP antibody in blood serum, the linearity of the detecting result is good, and the detecting process can be completed by 20 minutes, so that the method can be used for acquiring the detecting result more quickly as compared with the conventional ELISA detecting method consuming 2-3 hours.
Owner:SOUTHERN MEDICAL UNIVERSITY
Chemical synthesis method of plesiomonas shigelloides O51 serotype O-antigen oligosaccharide
The invention discloses a chemical synthesis method of plesiomonas shigelloides O51 serotype O-antigen oligosaccharide, and belongs to the field of chemistry. According to the chemical synthesis method, D-glucose with rich resources is adopted, L-fucose and D-glucosamine and the like serve as raw materials to prepare three kinds of glycosylation building blocks, a synthetic route composed of eleven reaction modules is designed, and the preparation of a target oligosaccharide chain is completed successfully through the optimization of a protecting group and the optimization of the introductiontiming of a modified group. Raw materials of the prepared oligosaccharide chain is cheap and obtained easily, the preparation method is simple and repeated easily, and the oligosaccharide chain has agood application prospect in the development of novel drugs and vaccines of plesiomonas shigelloides and the like.
Owner:JIANGNAN UNIV
Multi-component antigen acellular pertussis vaccine and preparation method thereof
ActiveCN101507814ABroad-spectrum antigenicityAntibacterial agentsBacterial antigen ingredientsCell freeType antigen
The invention relates to a multi-component antigen cell-free pertussis vaccine for preventing Bordetella pertussis infection and a preparation method thereof. The cell-free pertussis vaccine comprises multi-component cell structure antigen which is obtained by cracking, separating, extracting and purifying thalli cells of Bordetella pertussis liquid cultures, and can further comprise multi-component cell secretion-type antigen which is obtained by separating, extracting and purifying the supernatant part of the Bordetella pertussis liquid cultures. The combined vaccine is suitable for infants, children, teenagers and adults for preventing the Bordetella pertussis infection.
Owner:复星安特金(成都)生物制药有限公司
Vaccine composition, preparation method and application thereof
ActiveCN104043117AReduce the impactLess side effectsViral antigen ingredientsAntiviralsDiseaseSide effect
The invention provides a vaccine composition, a preparation method and an application thereof. The vaccine composition includes: an immune dose of porcine circovirus 2-type antigen, an immune dose of porcine Japanese encephalitis virus antigen, an immune dose of porcine parvovirus antigen and an adjuvant. The vaccine composition can effectively prevent and cure postweaning piglet multisystemic syndrome and sow reproduction dysfunctional diseases which are caused by 2-type porcine circovirus, porcine Japanese encephalitis virus and porcine parvovirus. An immune effect of the vaccine composition is better than that of a single vaccine. The vaccine composition is little in side effects, is high in valence of a serum antibody, has a long immune period, can save time and labor intensity, has a small stress response to a pig, can simplify immunity processes and can reduce production cost and prevention cost.
Owner:PU LIKE BIO ENG
Composition for Preventing or Treating Cervical Cancer Having Human Papillomavirus Plasmodium and Immunity Enhancer
ActiveUS20130195905A1Improving immunogenicityAntibody mimetics/scaffoldsMicroorganismsSequence signalAntigen
A composition for preventing or treating cervical cancer comprising a human papillomavirus plasmodium and an immunity enhancer is provided. A fusion protein including a fusion polypeptide recombined to transform a 3D structure of E6 and E7, which are antigens against types 16 and 18 human papillomavirus (HPV), a signal peptide for secreting the fusion polypeptide outside the cells and an immunity enhancer peptide present in an individual is also provided. The fusion protein may be useful in treating HPV-triggered tumors by inducing an immune response specific to the antigens against the HPV types 16 and 18.
Owner:GENEXINE INC
Artificial antigen submit cell and preparation method thereof
InactiveCN101041816AEfficient activationInhibit apoptosisVector-based foreign material introductionForeign genetic material cellsAntigenCD86
The invention discloses an artificial antigen submitting cell and preparing method, which comprises the following steps: choosing human chronic granular leukocyte leukemia bacterial strain K562 cell as carrier; transfer-dying and expressing eucaryon expressing carrier of CD32a; expressing CD32 molecular on the surface of K562 cell stably through G418 screening and flowed cell sorting device sorting; forming K32 cell; producing eucaryon expressing carrier of double expressing CD86 and 4-1BBL co-simulating signal; proceeding homomycin screen and sort with flowed cell device for the K32 cell; getting stable expression K32 cell of CD86 and 4-1BBL molecule; getting the end product. This invention possesses low cost and good repeatability, which can inhibit die effectively.
Owner:YANGZHOU UNIV
Synthesizing method for helicobacter pylori O:6 serotype O-antigen sugar chains
ActiveCN109776632AThe method steps are simpleLow costAntibacterial agentsSugar derivativesAntigenChemical reaction
The invention discloses a synthesizing method for helicobacter pylori O:6 serotype O-antigen sugar chains, and belongs to the field of sugar chemistry. According to the synthesizing method, aminolinkis assembled at the reduction tail ends of the helicobacter pylori O:6 serotype O-antigen sugar chains, and synthetic oligosaccharide chains can be coupled with carrier molecules or can be immobilizedon corresponding substrates. D-glucosamine, D-galactose, D-mannose and L-fucose which are low in cost and easy to obtain are used as starting materials, and through a series of chemical reactions, seven glycosylated blocks are obtained; then the sugar blocks are used, and under the effect of a corresponding activating reagent, through a series of glycosidation reactions, the multiple helicobacterpylori O:6 serotype O-antigen sugar chains are obtained through coupling. The oligosaccharide chains prepared with the method, the raw materials are low in cost and easy to obtain, the preparing method is simple and easy to repeat, and the oligosaccharide chains have good application prospects in the aspects such as novel drugs and vaccine development of helicobacter pylori.
Owner:JIANGNAN UNIV
Preparation of duck hepatitis I type virus indirect hemagglutination diagnostic antigen and kit
InactiveCN101423548AQuick responseEasy to useVirus peptidesMaterial analysisDuck hepatitis A virusType antigen
The invention relates to a method for preparing Duck hepatitis virus I type indirect blood coagulation diagnosing antigen, in particular to a method for preparing indirect blood coagulation diagnosing antigen by Duck hepatitis virus I type antigen sensibilization double hydroformylation mutton red cell. The Duck hepatitis virus I type indirect blood coagulation diagnosing antigen produced by the method has long storage time up to half a year; moreover, the diagnosing time is shortened and only half an hour is needed, and the use is convenient and simple; therefore, the method is suitable to be popularized and applied to the practical production.
Owner:陶海静
Enterovirus 71 antigen detection test strip (colloidal gold method)
InactiveCN102243237AImprove featuresHigh sensitivityMaterial analysisCase fatality ratePulmonary edema
The invention relates to the field of biomedicine, and specifically relates to an enterovirus 71 antigen detection test strip (colloidal gold method) and a preparation method and application thereof. Enterovirus 71 can cause hand-foot-and-mouth disease, which has largegeneration proportion of severe infections (viral encephalitis, meningomyelitis virus and pulmonary edema), and a high death rate reaching 10%-25%. The test strip of the invention is used for rapid diagnosis of EV(enterovirus)71 infection. A virus separation and an RT-PCR (reverse transcription-polymerase chain reaction) are methods first used for EV71 antigen detection, but are not suitable for primary clinic usage due to defects of difficult operation and high costs, etc. The invention overcomes the above insufficiencies and provides a reagent, which is highly demanded in clinic detection, simply operated, suitable for various medical disease control sections, and capable of detecting EV71 antigens in human oropharyngeal swabs, bubble liquid, serum or excrement, and also provides the preparation method and application thereof. A technical scheme is as follows: a specimen is dropped on a sample pad, and the EV71 antigen wherein combines with a gold-labeled EV71 polyclonal antibody in a gold-labeled pad and migrates along a chromatography membrane. A detected line captures colloidal gold particles to form a red line visible to naked eyes, so as to realize detection of the EV71 antigen.
Owner:BEIJING BEIER BIOENG
Casset based on solid-phase type quick blood grouping and grouping method
PendingCN107907696AEasy to operateEasy to carryBiological testingErythrocyte membraneBlood group antigens
The invention relates to a casset based on solid-phase type quick blood grouping and a grouping method. The casset comprises a casset body, a sample groove, an antibody groove and a gold mark groove,wherein the sample groove is arranged in the middle part of the casset body; the antibody groove is arranged at one side of the sample groove; the gold mark groove is arranged at the other side of thesample groove; a monoclonal antibody is arranged in the antibody groove; a gold mark erythrocyte membrane antigen is arranged in the gold mark groove; an upper water absorbing paper is arranged between the sample groove and the antibody groove; a blood filtering membrane is arranged between the sample groove and the gold mark groove; a lower water absorbing paper is arranged under the blood filtering membrane. The casset has the advantages that the anti-A, anti-B and anti-D specific monoclonal antibodies are used as positive typing reagents of A, B and O blood groups, the A, B and O blood group antigens (gold mark antigens) marked with the specific erythrocyte membranes are used as reverse typing immune colloidal gold reagents, and the positive and reverse typing reagents are respectivelyarranged on the casset body; the operation is simple and quick, the carrying is convenient, the accuracy is high, the casset is suitable for the condition that the positive and reverse typing reagents of the blood group typing reagent are simultaneously placed into a blasting ball at mobile blood collection sites and during emergency blood transfusion.
Owner:BEIQIUEN INT PEACE HOSPITAL P L A
Human VEGFR-1 (Vascular Endothelial Growth Factor Receptor-1) targeting genetically engineered lymphocyte as well as preparation method and application thereof
ActiveCN102584999AHigh activitySuppress generationPolypeptide with localisation/targeting motifImmunoglobulin superfamilySingle-Chain AntibodiesPlasmid Vector
The invention relates to the field of gene engineering, and particularly relates to an anti-VEGFR-1 (Vascular Endothelial Growth Factor Receptor-1) mosaic type antigen receptor and lymphocyte capable of expressing the antigen receptor, and aims at providing a new and effective choice for the technical field of antitumor. The technical scheme for solving the technical problems is as follows: a single-chain antibody ScFv is provided, the single-chain antibody can recognize VEGFR-1, the single-chain antibody is prepared into the mosaic type antigen receptor which has a structure of (ScFv-V)-(IgG1-Fc)-(CD4-TM)-(CD3-z), the encoding gene of the antigen receptor is transformed into a plasmid vector, and the plasmid vector is transfected to lymphocyte, so that the lymphocyte has antitumor action, thereby providing the new and effective choice for the field.
Owner:SICHUAN UNIV +1
Avian adenovirus fiber protein subunit vaccine
InactiveCN110128508AHigh antigen stabilityHigh purityViral antigen ingredientsVirus peptidesEscherichia coliNucleotide
The invention provides an avian adenovirus fiber protein subunit vaccine. A new-type antigen fiber protein of an avian adenovirus is used, after a sequence is optimized, the fiber protein acquires soluble expression in escherichia coli, and an expression product is used for preparing the subunit vaccine, wherein an amino acid sequence of the avian adenovirus fiber antigen protein is SEQ ID NO: 4,and a nucleotide sequence of an encoding gene thereof is SEQ ID NO: 3. The subunit vaccine prepared by the avian adenovirus fiber protein has the characteristics of high antigen stability, high purity, strong specificity, no generation of other uncorrelated antibodies, and convenient and accurate detection method. A firm foundation is established for industrially producing the avian adenovirus subunit vaccine and diagnostic reagent.
Owner:YEBIO BIOENG OF QINGDAO
Linear epitope minimum motif peptide of human papilloma virus type 58 L1 protein and application thereof
The invention belongs to the technical field of biomedicine and bioinstrumentation, in particular to an epitope (Bcellepitope) minimum motif peptide of human papilloma virus (HPV) type 58 L1 structural protein and application thereof. The invention provides 16 amino acid sequences containing minimum motif peptide (including 8 peptide sequence capable of cutting off expression of carrier protein such as GST188), and the amino acid sequences can be taken as antigen for independently or combinedly specific detection of blood serum of HPV type 58 virus infection patient and can be used for developing preventive HPV type 58 multi-epitope peptide vaccine capable of simultaneously inducing humoral immunity. The amino acid sequences of HPV type 58 L1 epitope minimum motif peptide and short peptide are shown as SEQIDNo.1-SEQIDNo.32.
Owner:广东南湾医药技术有限公司
Porcine circovirus II type-porcine pseudorabies double-combination vaccine, and preparation methods and application thereof
InactiveCN103920146ALow costReduce the number of vaccinationsViral antigen ingredientsAntiviralsImmune effectsCircovirus
The invention relates to a porcine circovirus II type-porcine pseudorabies double-combination vaccine which is characterized by including at least one porcine circovirus II type antigen and at least one porcine pseudorabies virus antigen. The invention also relates to two preparation methods of the double-combination vaccine. One method comprises the steps: inactivating the porcine circovirus II type to obtain a porcine circovirus II type inactivated vaccine; and mixing the porcine pseudorabies virus antigen with a freeze-drying protective agent to obtain a porcine pseudorabies freeze-drying living vaccine, and then dissolving the porcine pseudorabies freeze-drying living vaccine with the inactivated vaccine as a diluent to obtain the porcine circovirus II type-porcine pseudorabies double-combination vaccine composition. The other method comprises the steps: mixing the porcine circovirus II type antigen with the porcine pseudorabies virus antigen in proportion, and then mixing with the freeze-drying protective agent to obtain the double-combination freeze-drying vaccine. With use of the double-combination vaccine, the cold chain operating cost can be greatly reduced; and the combination vaccine has a synergistic role in the immune effect on the porcine pseudorabies virus antigen, and does not affect the immune effect of the porcine circovirus antigen.
Owner:PU LIKE BIO ENG
Antigen detection method and detection device made up by using said method
The present invention relates to a new type antigen detection method. Said method utilizes the direct combination of antibody Fc fragment specific oligonucleotide ligand and antibody, and converts the antibody signal into nucleic acid signal, then utilizes PCR amplification technique to detect antigen. The utilization of said method can form the detection kit or develop practical protein ship or other biological chip for detecting other various antigens.
Owner:INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA +1
Peptide mimics of conserved gonococcal epitopes and methods and compositions using them
Owner:UNIV OF MASSACHSETTS
Detection method formolecular typing of acinetobacter baumannii (Ab) Sv4-serotype O antigen
PendingCN110819730AImprove accuracyGood repeatabilityMicrobiological testing/measurementMicroorganism based processesSerotypeBacilli
The invention relates to analysis of an acinetobacter baumannii (Ab) Sv4-serotype O antigen by using an MGB probe-based real-time fluorescent TaZMan polymerase chain reaction rapid detection system. Aspecific gene, Wzy, in an acinetobacter baumannii O antigen gene cluster is adopted as a target gene so as to establish a primer and MGB probe for typing the acinetobacter baumannii O antigen, and areliable route is provided for typing of the O antigen of acinetobacter baumannii in blood, urine, pus and a respiratory tract. When the MGB probe is applied to detection of acinetobacter baumannii inthe blood, urine, pus and respiratory tract, and O-antigen typing of acinetobacter baumannii is performed, high sensitivity, high specificity, rapid detection and other advantages are achieved.
Owner:NANKAI UNIV
Preparation of red blood cells with a modified level of blood group antigen expression and their use in the quality control of blood typing reagents
The invention is a method of preparing the red corpuscle of low-expression blood group antigen adopting at least one immunodominant glucoamylase, such as N-acetylgalactosaminase or Alpha-galactosidase. The antigen expressed by the red corpuscle which is prepared by the method only reaches the threshold value of the antigen level that can be detected at clinic substantively. The red corpuscle prepared by this process can be applied to the quality control of the blood group reagent and the adjustment of the testing system, therefore can judge the blood group accurately and standardly.
Owner:KODE BIOTECH
Ready-to-use rapid enzyme immune tissue chemical reagent kit for detecting SCML2
ActiveCN104991073AReduce workloadReduce mistakesBiological material analysisBiological testingPhosphateType antigen
The invention discloses a ready-to-use rapid enzyme immune tissue chemical reagent kit for detecting SCML2. The ready-to-use rapid enzyme immune tissue chemical reagent kit comprises a kit body, the kit body is provided with a 3% H2O2 deionized water container, a powder type antigen repair solution container and a powder type phosphate buffer solution container, and the kit body is further provided with a monoclonal mouse anti-human SCML2 antibody container, a polymer enhancer container, an HRP enzyme-labeled mouse IgG polymer container and a diaminobenzidine container; a reagent in the reagent kit comprises the components of 3% H2O2, powder type antigen repair solutions, powder type phosphate buffer solutions, monoclonal mouse anti-human SCML2 antibodies, polymer enhancers, HRP enzyme-labeled mouse IgG polymers and diaminobenzidine. The ready-to-use rapid enzyme immune tissue chemical reagent kit for detecting SCML2 has the advantages that the detection operation process is greatly simplified, and it can be guaranteed that the detection result has good quality control; the ready-to-use rapid enzyme immune tissue chemical reagent kit for detecting SCML2 further has the advantages of being simple, fast to use, sensitive, universal, good in reproducibility and low in cost.
Owner:AFFILIATED HOSPITAL OF NANTONG UNIV
Pig circular ring virus 2 type antigen subtype identifying test paper card
ActiveCN101413950AStrong specificityIncreased sensitivityMaterial analysisCelluloseAbsorbent material
A PCV2 antigen subtype identification test paper card is applicable to pig PCV2 subtype identification. A reaction reagent carrier absorption layer comprises a fiber layer, a gold-labeled fiber layer, a cellulose membrane layer and a water absorbent material layer; wherein the gold-labeled fiber layer is gold-labeled glass cotton of an anti-capsid protein monoclonal antibody which absorbs a colloidal gold marker and can identify PCV common antigen epitope, detection blots T1, T2 and T3 and a control blot C are printed on the cellulose membrane layer; the detection blot T1 is the blot which is printedby anti-capsid protein monoclonal antibody solution and used for identifying <1767>PCV2 subtype specific antigen epitope, the detection blot T2 is the blot which is printed by the anti-capsid proteinmonoclonal antibody solution and used for identifying <1766>PCV2 and <1767>PCV2 common antigen epitope, the detection blot T3 is the blot which is printed by the anti-capsid protein monoclonal antibody solution and used for identifying PCV2 common antigen epitope, and the control blot C is the blot which is printed by anti-mouse IgG polyclonal antibody solution. The test paper card has strong specificity, high sensitivity, intuitive detection result as well as easy popularization and application.
Owner:ZHEJIANG UNIV
Peptide and Antibody Test Material for Detecting Both Vivax Malaria and Falciparum Malaria
InactiveUS20150285796A1Efficiently determinedImmunoglobulinsCarrier-bound/immobilised peptidesProtozoaAntigen
An object of the present invention is to provide a novel antigen peptide that can be used as an antibody test material for anti-malaria protozoa antibodies, which comprises as an active ingredient a peptide comprising the amino acid sequence of SEQ ID NO: 3.
Owner:NAT CENT FOR GLOBAL HEALTH & MEDICINE
Bivalent egg yolk antibody against DVH (duck virus hepatitis) as well as preparation method and application of bivalent egg yolk antibody
ActiveCN106854647AImprove securityEffective separation and purificationEgg immunoglobulinsSsRNA viruses positive-senseDuck hepatitis A virusYolk
Owner:PU LIKE BIO ENG
Composition containing human papilloma virus (HPV) plasmodium and immunopotentiator and being used for preventing or treating cervical cancer
InactiveCN105463001APolypeptide with localisation/targeting motifViral antigen ingredientsType antigenCervical carcinoma
The invention relates to a composition containing a human papilloma virus (HPV) plasmodium and an immunopotentiator and being used for preventing or treating cervical cancer. The composition is characterized in that fusion protein is used for treating tumors caused by HPV through inducing HPV 16 and 18 type antigen-specific immune response, wherein the fusion protein comprises fusion polypeptide which is recombined to enable the three dimensional structures of HPV 16 and 18 type antigens E6 and E7 to deform; signal peptide which is used for secreting the fusion polypeptide; immunological enhancement peptide.
Owner:GENEXINE CO LTD
Duck viral hepatitis bivalent yolk antibody, preparation method and application thereof
InactiveCN103865884AImprove securityEffective separation and purificationEgg immunoglobulinsSsRNA viruses positive-senseYolkOctanoic Acids
The present invention provides a duck viral hepatitis bivalent yolk antibody and a preparation method thereof, wherein the bivalent yolk antibody comprises a duck viral hepatitis DHAV-1 type antibody and a duck viral hepatitis DHAV-3 type antibody. The preparation method comprises: (1) adopting a duck viral hepatitis DHAV-1 type strain and a duck viral hepatitis DHAV-3 type strain to respectively vaccinate SPF chicken embryo and susceptible duck embryo, harvesting allantoic fluid, mixing the harvested virus liquids according to a certain ratio, carrying out formaldehyde inactivation, and preparing a vaccine; (2) adopting the vaccine to immunize laying hens, sampling after immunization to determine whether the neutralizing titer of the anti-DHAV-1 type antigen antibody and the anti-DHAV-3 type antigen antibody in the chicken hyperimmune egg yolk is more than or equal to 1:8192, and collecting the hyperimmune egg of the chicken; and (3) disinfecting the eggshell of the hyperimmune egg, collecting the egg yolk, adding the equal volume of distilled water, uniformly stirring and mixing, carrying out low temperature pasteurization inactivation, adopting an acidification distilled water method to purify, adopting an octanoic acid method to purify, and carrying out micro-filtration and ultra-filtration. The duck viral hepatitis bivalent yolk antibody has characteristics of low cost and high titer, and can be provided for effectively controlling duck viral hepatitis caused by DHAV-1 and DHAV-3 so as to obtain significant social benefits.
Owner:PU LIKE BIO ENG
Immunogenic polypeptide for enterovirus 71 type VP1 antigen as well as preparation method and application of immunogenic polypeptide
ActiveCN105294843AGood antigenicityImproving immunogenicitySsRNA viruses positive-senseBacteriaEnterovirus 71Vaccine Immunogenicity
The invention belongs to the field of immunobiology, relates to immunogenic polypeptide for an enterovirus 71 type VP1 antigen as well as a preparation method and application of immunogenic polypeptide, in particular to immunogenic polypeptide for the enterovirus 71 type VP1 antigen, which has an amino acid sequence shown in any of sequence tables SEQ ID No.1-SEQ ID No.5 or has an amino acid sequence which has the same function and formed by replacing, deleting or adding one or more amino acids. The invention further relates to the preparation method of immunogenic polypeptide and application of immunogenic polypeptide to preparation of diagnostic reagents for EV71 viruses. The immunogenic polypeptide has good antigenicity and immunogenicity and provides a research foundation for development of diagnostic reagents and research on vaccines of EV71 at an early stage.
Owner:SHANDONG UNIV +1
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