The invention discloses an O type foot-and-mouth
disease virus variant as well as a coding
gene and application thereof. In the invention, an O type foot-and-mouth
disease virus pan-Asia strain O / YS / CHA / 05 is firstly separated out, the
nucleotide sequence of the O type foot-and-mouth
disease virus pan-Asia strain O / YS / CHA / 05 SEQ ID NO: 1, and the
amino acid sequence is SEQ ID NO: 2. In comparison with a VP1
amino acid sequence, the
virus strain has 7 variable sites, five of which are centralized in a G-H ring.
Mutation of the sites ensures that the virus variant has the capability of escaping from
host immunity so as to have the superiority for becoming a popular
virus strain. Therefore, the variant can be employed to prepare an
inactivated vaccine for prevention and treatment of the variant and relevant strains, dominant
antigen epitope of the variant can be employed to prepare a synthetic
peptide vaccine, and the variant can be employed to develop novel O type foot-and-mouth disease virus vaccines such as VLP vaccine and the like. Therefore, the invention has important value in controlling the popularity of O / YS / CHA / 05 and relevant variable strains.