179 results about "Sugar derivatives" patented technology

Glucoside and glucuronide derivatives of hydromorphone, dihydromorphine, and dihydroisomorphine and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a glucoside or glucuronide derivative of hydromorphone, dihydromorphine, or dihydroisomorphine or a pharmaceutically acceptable salt thereof; and methods for treating or preventing pain in a patient comprising administering to a patient in need thereof a glucoside or glucuronide derivative of hydromorphone, dihydromorphine, or dihydroisomorphine or a pharmaceutically acceptable salt thereof are disclosed.

The present invention provides carbohydrate encapsulated nanoparticles. In particular, the present invention provides metallic nanoparticles (e.g. gold nanoparticles) that are encapsulated in biologically important carbohydrate molecules, such as sugars, sugar derivatives, P-blood group antigens and analogues thereof. The present invention also provides methods of employing these carbohydrate encapsulated nanoparticles in diagnostic and therapeutic applications.

Imino sugars, such as deoxynojirimycin (DNJ), are glucose analogues that selectively inhibit cellular α-glucosidase I and II (enzymes that process N-linked glycans in glycoprotein) and exhibit broad spectrum antiviral activities against many enveloped viruses. Previously we have reported a novel DNJ derivative, OSL-95II, with antiviral activity and reduced cytotoxicity. In order to develop imino sugars with more potent antiviral activity as well as improved toxicity profile, OSL-95II was modified by diversifying the nitrogen linked alkylated side chain. The antiviral activities were initially tested in bovine viral diarrhea virus (BVDV) infected MDBK cells, yielding several imino sugar derivatives with novel structure and superior antiviral activity and toxicity profile. Furthermore, these new compounds were shown to be active against Dengue virus (DV) and West Nile virus (WNV) infection in BHK cells where potent anti-DV activity having submicromolar EC50 values and SI of greater than 900. These compounds represent a new generation of iminio sugars and their analogues, having application in the clinical treatment of infection of DV and other members of flaviviridae.

A polishing agent of the invention comprises tetravalent metal hydroxide particles, a cationized polyvinyl alcohol, at least one type of saccharide selected from the group consisting of an amino sugar, a derivative of the amino sugar, a polysaccharide containing an amino sugar and a derivative of the polysaccharide, and water. The method for polishing a substrate of the invention comprises a step of polishing the silicon oxide film 1 (film to be polished), formed on the silicon substrate 2 having the silicon oxide film 1, by relatively moving the silicon substrate 2 and a polishing platen, in a state that the silicon oxide film 1 is pressed against a polishing pad on the polishing platen, while supplying the polishing agent of the invention between the silicon oxide film 1 and the polishing pad.

The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and / or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of α,α-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.

The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and / or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of alpha , alpha -trehalose and one or more members selected from substances having any one of blood flow-promoting effect , antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.

The present invention relates to a method of producing an animal food product with a core and a shell at least partially covering the core, in which the core starting material includes meat and / or meat-like components, water, oil and / or fat, vitamins, minerals, salts, antioxidising agents, dyes and / or preservatives, vegetable fibres, and other ingredients. The shell starting material includes vegetable and / or animal protein, cereal, starch and / or dextrin, blood plasma, water, cereal derivative and / or sugar or sugar derivative, and vitamins, minerals, salts, antioxidising agents, dyes and / or preservatives. The method includes the steps of: either producing core particles by mixing the core materials, baking the mixture thus obtained, conditioning, cutting into small pieces and conditioning again, or producing core particles by mixing the core materials, cold forming the mixture thus obtained and cutting it into small pieces, and then mixing the core particles with the components of the shell in a coating pan, baking or deep-frying and finally conditioning.

Peritoneal dialysis fluids and the use thereof for performing peritoneal dialysis are disclosed. The peritoneal dialysis fluid comprises a physiologically acceptable aqueous solution containing physiologically acceptable inorganic anions and cations and, as an osmotic agent, at least one sugar derivative, at concentrations sufficient for the removal of water and solutes from a patient by peritoneal dialysis. The sugar derivative is a compound of formulawherein each SG, which may be the same or different, represents a residue of a physiologically acceptable metabolizable sugar, SA represents a residue of a physiologically acceptable metabolizable sugar alcohol, n is from 1 to 4 andrepresents a glycoside linkage which is cleavable by an alpha-glycosidase enzyme.

The invention provides a method of improving the viscosity stability upon storage of a fabric softening composition comprising: (a) 0.5% to 30% by weight of at least one ester-linked quaternary ammonium fabric softening compound, (b) perfume, and (c) an alkoxylated nonionic surfactant, by the inclusion in the composition of at least one oily sugar derivative in a weight ratio of softening compound to sugar derivative in the range 30:1 to 1:1. Also provided are a fabric softening composition produced by the method of the invention, a method of treating fabric by applying thereto said composition and the use of a particular oily sugar derivatives to provide viscosity stability at 37° C. to a fabric softening composition comprising 0.5% to 30% by weight of at least one ester-linked quaternary ammonium fabric softening compound, a perfume and an alkoxylated nonionic surfactant.

The present invention relates to an antibody comprising a GlcNAc-S(A)x substituent, wherein S(A)x is a sugar derivative comprising x functional groups A wherein A is independently selected from the group consisting of an azido group, a keto group and an alkynyl group and x is 1, 2, 3 or 4, wherein said GlcNAc-S(A)x substituent is bonded to the antibody via CI of the N-acetylglucosamine of said GlcNAc-S(A)x substituent, and wherein said N-acetylglucosamine is optionally fucosylated. The invention also relates to an antibody-conjugate, in particular to an antibody-conjugate according to the Formula (20) or (20b), wherein AB is an antibody, S is a sugar or a sugar derivative, D is a molecule of interest, and wherein said N-acetylglucosamine is optionally fucosylated (b is 0 or 1). The invention further relates to a process for the preparation of a modified antibody, to a process for the preparation of an antibody-conjugate, and to said antibody-conjugate for use as a medicament. In addition, the invention relates to a kit of parts comprising an azide-modified antibody and a linker-conjugate, wherein said linker-conjugate comprises a (hetero)cycloalkynyl group and one or more molecules of interest.

Glycoproteins comprising a glycan of the formula (102) are disclosed; wherein b is 0 or 1; the GlcNAc residue optionally fucosylated; and Su(A)x is a sugar derivative comprising x functional groups A, wherein x is 1, 2, 3 or 4 and A is independently selected from the group consisting of an azido group, a keto group, an alkynyl group, a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonylated hydroxyacetamido group.Protein-conjugates having glycoproteins according to the invention conjugated to a molecule of interest (e.g., an active substance) are also disclosed. Examples include modified antibodies, antibody-conjugates, and antibody-drug conjugates (ADCs). Processes for the preparation of the modified glycoproteins according to the invention and methods for the preparation of a protein-conjugate according to the invention are mentioned.

An article containing N-acylchitosan is manufactured by a process comprising the steps of providing a mixture containing chitosan and / or N-acylchitosan, and extruding the mixture to form an N-acylchitosan hydrogel. Alternatively, the process comprising the steps of providing a chitosan and / or N-acylchitosan hydrogel, and extruding the hydrogel. An article with a memorized shape is formed by fixing the N-acylchitosan hydrogel in a desired shape, and at least partially drying the fixed hydrogel. A patient is treated by injecting the N-acylchitosan hydrogel.

The invention provides a method for the preparation of an aqueous fabric softening composition comprising; (i) at least one cationic fabric softening compound having two or more alkyl or alkenyl chains each having an average chain length equal to, or greater than, C8 and (ii) at least one oily sugar derivative, wherein the cationic fabric softening compound (i), and / or the oily sugar derivative (ii) is / are separately mixed with another active component of the fabric softening composition to form a pre-mixture prior to the admixing of the softening compound (i) with the oily sugar derivative (ii). The invention also provides an aqueous based fabric softening composition produced by the method of the invention, and, a method of treating fabrics with the composition so produced.

The invention provides a fabric softening composition comprising; (i) one or more cationic fabric softening compound(s) having two or more alkyl or alkenyl chains each having an average chain length equal to, or greater than, C8, and (iv) at least one oily sugar derivative which is a liquid or soft solid derivative of a cyclic polyol or of a reduced saccharide, said derivative resulting from 35 to 100% of the hydroxyl groups in said polyol or in said saccharide being esterified or etherified, and wherein, the derivative has two or more ester or ether groups independently attached to a C8-C22 alkyl or alkenyl chain, and (v) a deposition aid comprising a mixture of one or more nonionic surfactant(s), and one or more one cationic polymer(s), and wherein the weight ratio of the nonionic surfactant to the cationic polymer is in the range 10:1 to 1:10. The invention also provides a method of treating fabric with the above compositions.

Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (HMF) and anhydrosugar alcohols such as sorbitans and isosorbide. The derivatives include HMF ethers, levulinic acid esters, and ether derivatives of the anhydrosugar alcohols. The described methods require lower reaction temperatures and shorter reaction times than similar non microwave mediated reactions known in the art. Typical reaction conditions are 120-210° C., and typical reaction times are 30 minutes or less.

The subject of the present invention is a method for suppressing moisture fluctuations in a composition, a composition with suppressed moisture fluctuations, and a moisture fluctuation inhibitor in the composition, and by providing a saccharide derivative containing α,α-trehalose in the composition A moisture fluctuation suppressing method as an active ingredient, a moisture fluctuation suppressing composition containing the saccharide derivative, a moisture fluctuation inhibitor containing the saccharide derivative as an active ingredient, and uses thereof solve the above-mentioned problems.

Sequestrants and inhibitors of protease are applied to the wound site through the use of wound dressing based carrier systems to which they may be optionally ionically or covalently bound for the purpose of the initiation or enhancement of healing associated with chronic non-healing wounds.

A crosslinkable polysaccharide derivative which has in the side chain of polysaccharide at least one active ester group reactive with an active hydrogen-containing group and which forms a crosslinked product through covalent bond between the active ester group and the active hydrogen-containing group upon contact with alkaline water. A composition and a medical treatment material containing the crosslinkable polysaccharide derivative. The crosslinkable polysaccharide derivative produces a high bond strength that meets clinical requirements. It avoids the risk of infection because it is based on a material which is not derived from living organisms. It in itself and its decomposition products have a low level of toxicity because it is formed from a synthetic material. It is biodegradable and bioabsorbable. It can be prepared readily and simply without requiring special apparatus at the time of use.

Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behaviour with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behaviour renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.

The invention discloses a quantitative detection method of polysaccharide containing uronic acid. The method comprises the following steps: preparing a standard polysaccharide solution and a sample solution to be tested; hydrolyzing polysaccharide in the standard solution and the sample solution to be tested so as to obtain hydrolyzed residue; derivatizing the residue with 1-phenyl-3-methyl-5-pyrazolone to prepare a sugar derivative; carrying out chromatographic analysis on the sugar derivative by the utilization of a high performance liquid chromatograph and a triple quadrupole linear ion trap mass spectrometer; determining which kind of polysaccharide containing uronic acid the sample to be tested is according to the chromatogram; and preparing a standard curve of chromatographic peak area and polysaccharide concentration according to the chromatogram of the standard polysaccharide disaccharide derivative obtained by high performance liquid chromatography-mass spectrum, and calculating content of polysaccharide containing uronic acid in the sample to be tested by the utilization of peak area of the sample to be tested. According to the method provided by the invention, quantitative detection of polysaccharides can be accurately carried out, and effective means is provided for quality control of products such as medicines, health product and the like of the polysaccharides.

The invention provides a quinazoline sugar derivative and a preparation method and an application thereof, which are capable of solving the problems of low selection inhibitory activity and water solubility of tyrosine kinase inhibitor in the prior art. The glycosylation method of the quinazoline sugar derivative to quinazoline ring in the invention has easily-obtained raw materials, simple synthesis method, simple and convenient purification mode, better bioactivity, especially obvious inhibitory activity on EGFR, and remarkable anti-tumor effect so that the compound has wide prospect in medicines to prevent or cure tumors. The quinazoline sugar derivative has a structure formula as shown in the specification.

The invention relates to a method for preparing a hydrophobic modified low-molecular weight bletilla striata polysaccharide derivative and application of the derivative serving as a nano drug carrier in the field of biological medicines. The method comprises the following steps: performing purification, enzymolysis and refining on crude bletilla striata polysaccharide, thereby obtaining a low-molecular weight bletilla striata polysaccharide; carrying out a catalyst assisted reaction to graft a hydrophobic group, dialyzing the reaction liquid, and performing freeze drying, thereby obtaining the hydrophobic modified low-molecular weight bletilla striata polysaccharide derivative. The obtained product can be self-assembled to form shell-hydrophilic and core-hydrophobic spherical nanoscale micelles in an aqueous solution, and the particle size of the micelles can be controlled to be in a range from 60nm to 800nm by regulating the molecular weight of the bletilla striata polysaccharide, the types of hydrophobic groups, the degree of substitution and other factors. The nano micelles can serve as a targeted delivery carrier of hydrophobic drugs and have good hepatic targeting properties.

The present invention relates to acetamido glucose derivatives of indomethacin and their synthesis process and use. The kinds of acetamido glucose derivatives of indomethacin prepared with indomethacin and acetamido glucose are 1-O-[1-(4-chloro-benzoyl)-5 -methoxy-2-methyl-3-indolyl-acetoxy]-2-acetylamino-2-deoxy-alpha-D-glucose and 6-O-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-3-indolyl-acetoxy]-2-acetylamino-2-deoxy-alpha-D-glucose. The derivatives of the present invention has the activity of inhibiting mouse ear dropsy caused by croton oil and may be used in preparing antiphlogistic medicine.

The present invention relates to a novel herbal composition for improving exercise physiology factors comprising saponins and sugar derivatives optionally along with pharmaceutically acceptable excipients. It also relates to the process of preparing the composition for improving exercise physiology factors comprising the steps of flaking, defatting, solvent extraction of seeds of trigonella species followed by concentration of the extract to obtain a saponin and sugar derivative. It also relates to the use of the composition for improving exercise physiology factors comprising, enhanced anabolic activity, enhanced muscle building, enhance creatine delivery and reuptake, an increase in testosterone levels and an enhanced immunity.

The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and / or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of α,α-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.

A stable silicone oil composition is provided which comprises: a) at least one silicone gel; b) at least one boron nitride powder (a); c) a static charge-dissipating amount of at least one silicone oil; and, d) optionnally at least one component selected from the group consisting of other silicone, surfactant, emulsifier, solvent, emollient, moisturizer, humectant, pigment, colorant, fragrance, preservative, antioxidant, biocide, biostat, antiperspirant, exfoliant, hormone, enzyme, medicinal, vitamin substance, hydroxy acid, retinol, retinol derivative, niacinamide, skin lightening agent, salt, electrolyte, alcohol, polyol, ester, ultraviolet radiation scattering and / or absorbing agent, botanical extract, peptide, protein, organic oil, gum, saccharide, oligosaccharide, polysaccharide, derivative, wax, film former, thickening agent, particulate filler, plasticizer, humectant, occlusive, sensory enhancer, resin and optically active particle.

For extending the uses of a compound represented by, Chemical formula 1, the object of the present invention is to provide a derivative of cyclic tetrasaccharide whose physicochemical properties are changed from those of cyclic tetrasaccaride, a composition comprising the same, and a process for producing the same. The present invention solves the above object by providing a derivative of cyclic tetrasaccharide, which is produced by the steps of reacting a compound represented by Chemical formula 1 with a reactive reagent and substituting one ore more hydroxyl groups with substituents except hydroxyl group and O-glycosyl group; a composition comprising the same; and a process for producing the derivative of cyclic tetrasaccharide. Chemical formula 1

The present invention provides a method for preparing a sample characterized by binding a substance A containing a hydrazide group to a sugar chain and / or a sugar derivative via hydrazone formation between the hydrazide group of the substance A and the reducing end of the sugar chain and / or the sugar derivative thereby to enable the separation and purification of the sugar chain and / or the sugar derivative for an analytical sample from a biological sample containing the sugar chain and / or the sugar derivative by a simple operation.