168 results about "Sugar derivatives" patented technology

Glucoside and glucuronide derivatives of hydromorphone, dihydromorphine, and dihydroisomorphine and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a glucoside or glucuronide derivative of hydromorphone, dihydromorphine, or dihydroisomorphine or a pharmaceutically acceptable salt thereof; and methods for treating or preventing pain in a patient comprising administering to a patient in need thereof a glucoside or glucuronide derivative of hydromorphone, dihydromorphine, or dihydroisomorphine or a pharmaceutically acceptable salt thereof are disclosed.

Imino sugars, such as deoxynojirimycin (DNJ), are glucose analogues that selectively inhibit cellular α-glucosidase I and II (enzymes that process N-linked glycans in glycoprotein) and exhibit broad spectrum antiviral activities against many enveloped viruses. Previously we have reported a novel DNJ derivative, OSL-95II, with antiviral activity and reduced cytotoxicity. In order to develop imino sugars with more potent antiviral activity as well as improved toxicity profile, OSL-95II was modified by diversifying the nitrogen linked alkylated side chain. The antiviral activities were initially tested in bovine viral diarrhea virus (BVDV) infected MDBK cells, yielding several imino sugar derivatives with novel structure and superior antiviral activity and toxicity profile. Furthermore, these new compounds were shown to be active against Dengue virus (DV) and West Nile virus (WNV) infection in BHK cells where potent anti-DV activity having submicromolar EC50 values and SI of greater than 900. These compounds represent a new generation of iminio sugars and their analogues, having application in the clinical treatment of infection of DV and other members of flaviviridae.

Peritoneal dialysis fluids and the use thereof for performing peritoneal dialysis are disclosed. The peritoneal dialysis fluid comprises a physiologically acceptable aqueous solution containing physiologically acceptable inorganic anions and cations and, as an osmotic agent, at least one sugar derivative, at concentrations sufficient for the removal of water and solutes from a patient by peritoneal dialysis. The sugar derivative is a compound of formulawherein each SG, which may be the same or different, represents a residue of a physiologically acceptable metabolizable sugar, SA represents a residue of a physiologically acceptable metabolizable sugar alcohol, n is from 1 to 4 andrepresents a glycoside linkage which is cleavable by an alpha-glycosidase enzyme.

The invention provides a method of improving the viscosity stability upon storage of a fabric softening composition comprising: (a) 0.5% to 30% by weight of at least one ester-linked quaternary ammonium fabric softening compound, (b) perfume, and (c) an alkoxylated nonionic surfactant, by the inclusion in the composition of at least one oily sugar derivative in a weight ratio of softening compound to sugar derivative in the range 30:1 to 1:1. Also provided are a fabric softening composition produced by the method of the invention, a method of treating fabric by applying thereto said composition and the use of a particular oily sugar derivatives to provide viscosity stability at 37° C. to a fabric softening composition comprising 0.5% to 30% by weight of at least one ester-linked quaternary ammonium fabric softening compound, a perfume and an alkoxylated nonionic surfactant.

The subject of the present invention is a method for suppressing moisture fluctuations in a composition, a composition with suppressed moisture fluctuations, and a moisture fluctuation inhibitor in the composition, and by providing a saccharide derivative containing α,α-trehalose in the composition A moisture fluctuation suppressing method as an active ingredient, a moisture fluctuation suppressing composition containing the saccharide derivative, a moisture fluctuation inhibitor containing the saccharide derivative as an active ingredient, and uses thereof solve the above-mentioned problems.

The invention provides a method for the preparation of an aqueous fabric softening composition comprising;(i) at least one cationic fabric softening compound having two or more alkyl or alkenyl chains each having an average chain length equal to, or greater than, C8 and(ii) at least one oily sugar derivative,wherein the cationic fabric softening compound (i), and / or the oily sugar derivative (ii) is / are separately mixed with another active component of the fabric softening composition to form a pre-mixture prior to the admixing of the softening compound (i) with the oily sugar derivative (ii).The invention also provides an aqueous based fabric softening composition produced by the method of the invention, and, a method of treating fabrics with the composition so produced.

Sequestrants and inhibitors of protease are applied to the wound site through the use of wound dressing based carrier systems to which they may be optionally ionically or covalently bound for the purpose of the initiation or enhancement of healing associated with chronic non-healing wounds.

The invention discloses a quantitative detection method of polysaccharide containing uronic acid. The method comprises the following steps: preparing a standard polysaccharide solution and a sample solution to be tested; hydrolyzing polysaccharide in the standard solution and the sample solution to be tested so as to obtain hydrolyzed residue; derivatizing the residue with 1-phenyl-3-methyl-5-pyrazolone to prepare a sugar derivative; carrying out chromatographic analysis on the sugar derivative by the utilization of a high performance liquid chromatograph and a triple quadrupole linear ion trap mass spectrometer; determining which kind of polysaccharide containing uronic acid the sample to be tested is according to the chromatogram; and preparing a standard curve of chromatographic peak area and polysaccharide concentration according to the chromatogram of the standard polysaccharide disaccharide derivative obtained by high performance liquid chromatography-mass spectrum, and calculating content of polysaccharide containing uronic acid in the sample to be tested by the utilization of peak area of the sample to be tested. According to the method provided by the invention, quantitative detection of polysaccharides can be accurately carried out, and effective means is provided for quality control of products such as medicines, health product and the like of the polysaccharides.

The invention provides a quinazoline sugar derivative and a preparation method and an application thereof, which are capable of solving the problems of low selection inhibitory activity and water solubility of tyrosine kinase inhibitor in the prior art. The glycosylation method of the quinazoline sugar derivative to quinazoline ring in the invention has easily-obtained raw materials, simple synthesis method, simple and convenient purification mode, better bioactivity, especially obvious inhibitory activity on EGFR, and remarkable anti-tumor effect so that the compound has wide prospect in medicines to prevent or cure tumors. The quinazoline sugar derivative has a structure formula as shown in the specification.

The invention relates to a method for preparing a hydrophobic modified low-molecular weight bletilla striata polysaccharide derivative and application of the derivative serving as a nano drug carrier in the field of biological medicines. The method comprises the following steps: performing purification, enzymolysis and refining on crude bletilla striata polysaccharide, thereby obtaining a low-molecular weight bletilla striata polysaccharide; carrying out a catalyst assisted reaction to graft a hydrophobic group, dialyzing the reaction liquid, and performing freeze drying, thereby obtaining the hydrophobic modified low-molecular weight bletilla striata polysaccharide derivative. The obtained product can be self-assembled to form shell-hydrophilic and core-hydrophobic spherical nanoscale micelles in an aqueous solution, and the particle size of the micelles can be controlled to be in a range from 60nm to 800nm by regulating the molecular weight of the bletilla striata polysaccharide, the types of hydrophobic groups, the degree of substitution and other factors. The nano micelles can serve as a targeted delivery carrier of hydrophobic drugs and have good hepatic targeting properties.

The present invention relates to acetamido glucose derivatives of indomethacin and their synthesis process and use. The kinds of acetamido glucose derivatives of indomethacin prepared with indomethacin and acetamido glucose are 1-O-[1-(4-chloro-benzoyl)-5 -methoxy-2-methyl-3-indolyl-acetoxy]-2-acetylamino-2-deoxy-alpha-D-glucose and 6-O-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-3-indolyl-acetoxy]-2-acetylamino-2-deoxy-alpha-D-glucose. The derivatives of the present invention has the activity of inhibiting mouse ear dropsy caused by croton oil and may be used in preparing antiphlogistic medicine.

The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and / or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of α,α-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.

A stable silicone oil composition is provided which comprises: a) at least one silicone gel; b) at least one boron nitride powder (a); c) a static charge-dissipating amount of at least one silicone oil; and, d) optionnally at least one component selected from the group consisting of other silicone, surfactant, emulsifier, solvent, emollient, moisturizer, humectant, pigment, colorant, fragrance, preservative, antioxidant, biocide, biostat, antiperspirant, exfoliant, hormone, enzyme, medicinal, vitamin substance, hydroxy acid, retinol, retinol derivative, niacinamide, skin lightening agent, salt, electrolyte, alcohol, polyol, ester, ultraviolet radiation scattering and / or absorbing agent, botanical extract, peptide, protein, organic oil, gum, saccharide, oligosaccharide, polysaccharide, derivative, wax, film former, thickening agent, particulate filler, plasticizer, humectant, occlusive, sensory enhancer, resin and optically active particle.