Skin preparation for external use characterized by containing sugar derivative of a,a-trehalose

A technology for skin external preparations and sugar derivatives, which is applied in the direction of medical preparations containing active ingredients, skin care preparations, and medical preparations with no active ingredients, etc. It can solve the problem of no record of effective dose, poor stretching and irritation , without any specific records, etc.

Inactive Publication Date: 2006-04-19
HAYASHIBARA BIOCHEMICAL LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in these patent documents, substances having a blood circulation promoting effect, substances having an anti-inflammatory effect, substances having an antibacterial effect, substances having a moisturizing effect, substances having a whitening effect, substances having an ultraviolet absorbing effect, etc. substances with UV-scattering effect, substances with antioxidant effect, substances with hair-raising-hair-raising effect, substances with astringent effect, substances with anti-wrinkle effect, substances with α,α-Trehalose sugar derivatives confirmed in the case of percutaneous absorption-promoting substances have an inhibitory effect on the decrease in feeling of use such as stickiness, poor stretching, and increased irritation.
In addition, for α, the saccharide derivatives of α-trehalose have the effect of promoting blood circulation, substances with anti-inflammatory effects, substances with antibacterial effects, substances with moisturizing effects, substances with whitening effects, substances with Substances with ultraviolet absorbing effect, substances with ultraviolet scattering effect, substances with antioxidative effect, substances with hair raising-hair raising effect, substances with astringent effect, substances with anti-wrinkle effect, substances with cell revitalizing effect and substances with There is no specific description that the effect of the ingredients compounded in skin external preparations represented by substances that promote percutaneous absorption has an enhanced effect, and there is no specific description about the saccharide derivatives of α,α-trehalose and the effective amounts of these substances. record
In addition, among sugars containing sugar derivatives of α,α-trehalose, for sugars containing α,α-trehalose containing α-maltosyl α,α-trehalose as the main component, In addition to derivatives, sugars containing sugar alcohols are particularly excellent in these effects. There is no record

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082]Calcium carbonate was added to cornstarch milk with a concentration of 20% to make the final concentration 0.1%, and the pH was adjusted to 6.5, and α-amylase (manufactured by Nobo Corporation, trade name "タママミル 60L") was added thereto to make It was 0.2% per gram of starch and reacted at 95°C for 15 minutes. After autoclaving the reaction solution at 120°C for 10 minutes, cooling to 50°C, adjusting the pH to 5.8, adding maltotetraose disclosed in JP-A-63-240784 at 5 units per gram of starch Produce amylase (manufactured by Hayashibara Biochemical Research Institute of Co., Ltd.), 500 units of isoamylase (manufactured by Hayashibara Biochemical Research Institute of Co., Ltd.), react for 48 hours, and add 30 units of α-amylase per gram of starch thereto (manufactured by Ueda Chemical Co., Ltd., trade name "α-amylase 2A"), and reacted at 65° C. for 4 hours. The reaction solution was subjected to autoclave treatment at 120° C. for 10 minutes, then cooled to 45° C., and Q3...

Embodiment 2

[0084] The syrup prepared by the method of Example 1 was spray-dried by a conventional method to prepare an amorphous powder product. This product has low hygroscopicity and good water solubility, as in Example 1, and is suitable as a raw material for external skin preparations.

Embodiment 3

[0086] The saccharification solution prepared by the method of Example 1 was subjected to column fractionation using a salt type strongly acidic cation exchange resin (sold by Dow Chemicaul Co., Ltd., trade name "Dowex 50W-X4", Mg++ type). Four jacketed stainless steel columns with an inner diameter of 5.4 cm were filled with the resin and connected in series, and the total length of the resin layer was 20 m. While maintaining the temperature inside the column at 55°C, add a sugar solution of 5v / v% to the resin, and flow warm water at 55°C at SV 0.13 for fractionation, remove the high-content fraction of glucose and maltose, and collect α , α-trehalose saccharide derivatives high content fraction, and then refined and concentrated to prepare α, α-trehalose saccharide derivatives high content syrup. Furthermore, the syrup was spray-dried by a conventional method to prepare an amorphous high-content powder of α,α-trehalose sugar derivatives. This product contains 70.2% of α-mal...

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PUM

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Abstract

The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and / or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of alpha , alpha -trehalose and one or more members selected from substances having any one of blood flow-promoting effect , antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.

Description

technical field [0001] The present invention provides a skin external preparation containing a saccharide derivative of α,α-trehalose and a substance selected from a substance having a blood circulation promoting effect, a substance having an anti-inflammatory effect, a substance having an antibacterial effect, a substance having a moisturizing effect, Substances with whitening effect, substances with ultraviolet absorbing effect, substances with ultraviolet scattering effect, substances with antioxidative effect, substances with hair growth-hair raising effect, substances with astringent effect, substances with anti-wrinkle effect, Any one or two or more substances having a revitalizing action and / or substances having a percutaneous absorption-promoting action, the external preparation for skin does not produce a sticky feeling, has a good feeling of use, and the effects of these substances are enhanced. technical background [0002] Scalp, skin, etc. are accompanied by int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60A61Q17/00A61Q19/00A61K31/702A61K31/716A61K47/26C11D7/26C11D9/26C07H3/06C08B37/00A61K8/02A61K9/00A61K45/06A61Q1/02A61Q1/08A61Q1/10A61Q5/00A61Q5/02A61Q5/12A61Q7/00A61Q11/00A61Q17/04A61Q19/02A61Q19/08A61Q19/10
CPCA61Q1/02A61K2800/522A61Q5/02A61K31/716A61K45/06A61Q19/00A61Q19/02A61Q17/04A61K8/60A61K47/26A61Q7/00A61Q11/00A61Q19/08A61Q1/08A61Q19/10A61K9/0014A61Q1/10A61K31/702A61Q5/12A61Q17/005A61K8/0212A61P17/00A61P17/02A61P17/14A61P17/16A61P29/00A61P31/04A61P37/08A61K2300/00A61Q1/00
Inventor 田边富士美久保田伦夫立川博美福田惠温三宅俊雄
Owner HAYASHIBARA BIOCHEMICAL LAB INC
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