A hyperbranched polymer, and a preparing method and applications thereof
A technology of hyperbranched polymers and gadolinium compounds, which can be used in pharmaceutical formulations, preparations for in vivo tests, MRI/MRI contrast agents, etc., can solve the problems of limited application, incomplete excretion, etc. Low toxicity, simple preparation method, and the effect of improving relaxation efficiency
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[0032] Below, the embodiments of the present invention will be described in detail with reference to the accompanying drawings.
[0033] The present invention provides a kind of preparation method of the MRI contrast agent of hyperbranched polylysine as carrier, comprises the following steps:
[0034] Step 1: After fully grinding lysine hydrochloride and potassium hydroxide into a slurry in a mortar, use liquid paraffin oil as a heat transfer medium, and react at 150°C for 48 hours under a nitrogen protective atmosphere to obtain the main product overrun Polylysine backbone, as well as by-products and other impurities.
[0035] Wherein, the charging amount of described potassium hydroxide is 90% of the molar number of lysine hydrochloride.
[0036] Slowly cool to room temperature after the reaction in step 1 is completed. The liquid paraffin was poured off, washed repeatedly with petroleum ether, and then the petroleum ether was distilled off under reduced pressure to obtain...
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