44 results about "Clinical imaging" patented technology

The present invention relates to materials and methods useful in the study of cells and species associated with cells. Materials of the present invention may include emissive, photostable organic molecules (e.g., conjugated polymers, conjugated oligomers) that are appropriately functionalized to interact with a cell with essentially no disruption in normal cell functioning. The present invention may be useful in, for example, cell imaging, cell tracking, in vivo monitoring of cellular events, drug delivery, and determination of biological species. In one embodiment, a conjugated polymer or oligomer may be internalized into a cell and may exhibit a strong and stable emissive signal, allowing the cell to be monitored under extensive microscopic conditions for extended periods of time.

The present invention relates to materials and methods useful in the study of cells and species associated with cells. Materials of the present invention may include emissive, photostable organic molecules (e.g., conjugated polymers, conjugated oligomers) that are appropriately functionalized to interact with a cell with essentially no disruption in normal cell functioning. The present invention may be useful in, for example, cell imaging, cell tracking, in vivo monitoring of cellular events, drug delivery, and determination of biological species. In one embodiment, a conjugated polymer or oligomer may be internalized into a cell and may exhibit a strong and stable emissive signal, allowing the cell to be monitored under extensive microscopic conditions for extended periods of time.

The invention discloses a method and a system for filtering a medical image. The method comprises the following steps of: estimating the window size of a filter according to an image to be processed; calculating the frequency and amplitude of polar coordinates in a frequency domain and constructing a directional window filter; and performing filtering operation on the image to be processed by using the directional window filter and outputting the filtered image. The scheme provided by the invention can enhance the contrast of each tissue in the image in different degrees, particularly enhances a fine structure so as to make an organizational structure clearer by removing noise in the image which influences diagnosis to the greatest extent according to the diagnosis requirement of the medical image. Compared with the common filtering method, the method has the advantages of high noise suppression capability and prominent details; the filtered medical image can clearly reflect the information of the organizational structure in the image and provide powerful assistance and assurance for the diagnosis of clinical imageology to various diseases; and products formed by a correlation method can generate great social and economic benefits and has wide market prospect.

The invention belongs to the field of high-polymer materials and discloses a high-polymer vesicle containing AIE (aggregation-induced emission) molecules as well as a preparation method and an application of the high-polymer vesicle. The high-polymer vesicle is mainly formed through self-assembly of the AIE molecules and amphiphilic block copolymers; the outer layer and the inner layer of a high-polymer vesicle film are hydrophillic layers, each hydrophillic layer is formed by hydrophilic chain sections in the amphiphilic block copolymers, and a film intermediate layer between the outer layer and the inner layer is formed by hydrophobic chain sections in the amphiphilic block copolymers and the AIE molecules. The high-polymer vesicle has high fluorescence intensity and can meet different fluorescent staining demands. The preparation method is simple and feasible, the production efficiency is high, and the repeatability is good. The high-polymer vesicle can be used for related fields of optical bioimaging, biological detection and clinical imaging, high-polymer vesicle research and the like.

The present invention relates to the preparation and use of novel bone templates that can be prepared using a comprehensive approach to observing microstructural features of bone, including trabecular thickness and trabecular density. These features are assessed in regions of interest in a bone (e.g., proximal femur, distal femur, wrist, spine, etc.) as observed using digital radiographic techniques or clinical imaging, such as Dual Energy X-ray Absorptiometry (DEXA) and computed tomography (CT) scanners. The microstructural features are presented in the form of data based on scanning results and are also assessed and / or organized in terms of age, gender, race, pathology, clinical history, and other patient population parameters. The template can be used to assess bone quality, predict the likelihood of bone fracture, and evaluate prosthesis design and placement, based on an image of a corresponding subject bone, e.g. the bone of a patient.

In a clinical or preclinical imaging system, an image acquisition subsystem includes a data acquisition and image reconstruction elements generating clinical or preclinical images. A quantitative image processing subsystem generates variability metadata associated with the clinical or preclinical images, and a clinically or preclinically significant result with an associated confidence interval computed based on the variability metadata. A user interface displays the clinically or preclinically significant result together with the associated confidence interval. A phantom for calibrating such an imaging system includes a deformable nonbiological structure approximating structure of a clinical or preclinical subject to be imaged, and fiducial markers detectable by the imaging system disposed on or in the deformable nonbiological structure to move with deformation of the deformable nonbiological structure.

The present invention is method and device for obtaining internal heat source information from the surface temperature distribution of living body. The device consists of three parts: uncooled focal plane infrared detector, interface circuit and computer system. Human body infrared radiation is received with the uncooled focal plane infrared detector and treated with the interface circuit and computer system to obtain temperature distribution data on the body surface. By means of Pennes biothermal conducting equation, properly simplified mold to find out the analytic solution of the equation and corresponding computer software, the depth h and the strength q information of the abnormal intracorporeal heat source may be obtained conveniently and simply based on the temperature distribution data on the body surface. The present invention can provide useful reference for the clinical diagnosis of diseases in imaging science method.

The invention discloses a medical image segmentation or classification method based on small sample domain self-adaption, and the method comprises the steps: downloading medical image data and clinical image data from a public data set, and taking the processed medical image data as a source domain training data set with a known label; using the processed clinical image data as a to-be-classified or segmented target domain data set, marking a very small amount of clinical image data by a doctor, constructing a small sample domain self-adaption model by a feature extractor and a classifier realized by a convolutional neural network, and training to obtain a trained small sample domain self-adaption model; and inputting a to-be-classified or segmented target domain data set into the small sample domainself-adaption model with the best classification effect to obtain a classification or segmentation result to which the focus of the target domain data set belongs. Different objective functions are adopted according to whether the data contain labels or not, cross-domain migration of the small sample domain self-adaption model is achieved, and the method is applied to classification or segmentation of image data of clinic, pathology, ultrasound and the like.

The invention relates to a mammary-gland remote viewing method and system. The method includes the steps that clinical imaging information of patients is collected by a collecting workstation and sent to a cloud server to be stored; a remote terminal automatically extracts the clinical imaging information of the patients from the cloud server, and displays the clinical imaging information of a corresponding patient according to selection information input by a remote user; according to an input command of the remote user, under a viewing tab, the remote terminal measures and identifies regions of interest in the displayed clinical imaging information, and processes the displayed clinical imaging information, so that the remote user conducts identification, diagnosis and viewing; under a report tab, a remote report is generated according to an edit command of the remote user; the remote terminal sends the generated remote report to the cloud server; a local terminal extracts the remote report from the cloud server and outputs the remote report. The method and system solve actual demands of hospitals which suffer from expert shortage, and actually achieve sharing of experts and resources.

Generation of attenuation maps for nuclear medicine image reconstructions based on the use of anatomical image data, such as CT data, take into account variations caused by variations in acquisition energy width and emission energy of the radioisotope used in the clinical imaging procedure, as coefficient correction factors that are stored together with such maps.

The invention discloses a non-radiative percutaneous spine positioning method based on optical scanning automated outline segmentation matching. Through a clinical image data processing system, clinical CT (computed tomography) is imported, a three-dimensional model of the back outline and the spine of a human body can be reconstructed, and a three-dimensional model of the back outline of the human body is scanned, checked and reconstructed through structured light / TOF (Time Of Flight) optical scanning equipment, finally, a three-dimensional coordinate relationship between the spine model andthe optical scanning model of the back outline of the human body is displayed and output through the matching calculation of a three-dimensional image processing system. On the basis of optical scanning equipment, the method disclosed by the invention realizes the matching and the positioning of the spine model and the optical scanning model of the back outline of the human body, and has the advantages of no radiation, small land occupation, high scanning speed, visual display results, high repeatability and the like.

The present invention provides rotenone analogs and methods of making and using them. Labeled with single photon and positron emitting isotopes, the rotenone analogs of the present invention are useful in, for example, clinical imaging applications as tracers to measure cardiac blood flow and detect regions of ischemia.

The invention discloses a liver tumor angiogenesis quantitative analysis method based on dynamic ultrasound contrast. Through local perfusion mode difference quantification, the liver tumor angiogenesis quantitative analysis method constructs a network graph reflecting blood vessel distribution structures of normal tissues in and around a tumor, so that spatial heterogeneity of functions and formsof a tumor region is represented, and a new tumor angiogenesis quantitative evaluation method is provided for clinical imaging doctors. According to the liver tumor angiogenesis quantitative analysismethod, the local perfusion mode is extracted on the basis of inhibiting motion interference, and the local perfusion mode difference is quantified on the basis of perfusion phase constraint, and then the tumor local angiogenesis difference is represented through a complex network, so that heterogeneity characteristics associated with clinical tumor diagnosis and prognosis evaluation are mined.

Magnetic Resonance Imaging (MRI), which is given the acronym ULTRA (Unlimited Trains of Radio Acquisitions), can eliminate magnetic gradient reversals and allow simultaneous MR signal acquisition from the entire object volume in each of a multitude of very small receiver coils arranged in a 3D array around the imaging volume. This permits a rate of MR signal acquisition that is greatly increased (e.g. 256 times) compared with existing techniques, with a full 3D image constructed in as little as 1 millisecond. Furthermore, noise—both audible and electrical—is substantially reduced. The advantages over conventional MRI include:1. Clinical imaging can be completed in seconds or less, with good signal-to-noise ratio;2. Signal-to-noise ratio further increased by eliminating RF noise due to gradient switching;3. Real-time functional MRI on millisecond timescales;4. With single breath holds, high quality imaging of thorax and abdomen.5. Greatly reduced audible noise and vibration.

Magnetic Resonance Imaging (MRI), which is given the acronym ULTRA (Unlimited Trains of Radio Acquisitions), can eliminate magnetic gradient reversals and allow simultaneous MR signal acquisition from the entire object volume in each of a multitude of very small receiver coils arranged in a 3D array around the imaging volume. This permits a rate of MR signal acquisition that is greatly increased (e.g. 256 times) compared with existing techniques, with a full 3D image constructed in as little as 1 millisecond. Furthermore, noise—both audible and electrical—is substantially reduced. The advantages over conventional MRI include:1. Clinical imaging can be completed in seconds, with good signal-to-noise ratio;2. Signal-to-noise ratio is further increased by eliminating RF noise due to gradient switching;3. Real-time functional MRI is possible, on millisecond timescales;4. With single breath holds, high quality imaging of thorax and abdomen is possible.5. ULTRA greatly reduces audible noise and vibration.

The invention provides an artificial intelligence medical image quality control method applied to a clinical image, a technician collects a patient image and transmits the image to an artificial intelligence medical image quality control management system, and the artificial intelligence medical image quality control management system is used for performing semantic segmentation, classification processing and quality control scoring on the image. The score is displayed on an operation interface of a technician previewing image, and the technician judges whether to remark or recollect the image according to the quality control score and the condition of a patient, so that the generation of low-score image quality is reduced, the limitations of low efficiency, large workload, small quantity of quality control samples and strong subjectivity of traditional quality control are solved, accurate and effective quality control means are applied to the whole process from image data acquisition to diagnosis and are combined with primary technician and physician team management, and a standardized and intelligent image quality control system is established.

The invention provides a method for generating an operation record and assisting in management and application in an operating room through voice recognition, and the method comprises the following steps: pre-setting clinical related professional data in a voice recognition system, including clinical diagnosis information, diagnosis and treatment routines, a medicine library and an event library;before an operation, inputting operation list information into the system, wherein the operation list information comprises patient names, departments, inpatient areas, bed numbers, hospitalization numbers, operation doctors and operation nurse information; during an operation, acquiring the first-time voice record of an operation doctor through a doctor clip type microphone, wherein the system automatically identifies keywords and compares the keywords with background data, and automatically generates an operation record text correspondingly; meanwhile, recording the image data in the operation process through camera equipment; after the operation, enabling a surgeon to correspondingly manage clinical images and snapshots recorded in the operation by utilizing various events occurring ateach time node in the record according to an operation record generated in the operation, wherein the surgeon is supported to conveniently and quickly edit and generate a professional operation clinical report after the operation.

The present invention relates to the cryptophane derivatives of formula (I) capable of encapsulating small molecules such as noble gases for biological and environmental use. In particular, the invention relates to cryptophane derivatives with high affinity for xenon, which can be used as biosensors in clinical imaging.

An apparatus for transmitting and receiving radiofrequency (RF) signals in a magnetic resonance imaging system for proton and X-nuclear imaging includes at least one radiofrequency (RF) coil and an ultrahigh dielectric constant material incorporated within the at least one RF coil. The permittivity of the ultrahigh dielectric constant material depends on a temperature of the material and is tunable. The apparatus also includes a temperature controller that is thermally coupled to the ultrahigh dielectric constant material. The temperature controller is configured to control a temperature of the ultrahigh dielectric constant material to tune and optimize the permittivity of the ultrahigh dielectric constant material. A chemical structure and composition of the ultrahigh dielectric constant material is selected to control and optimize the permittivity and a dielectric loss of the ultrahigh dielectric constant material and a temperature dependence of the ultrahigh dielectric constant material. The apparatus provides denoising effect, high RF coil transmission and reception efficiencies, and improved signal-to-noise ratio for magnetic resonance or spectroscopic imaging applications and has a potential to advance clinical imaging for diagnosis.

The invention discloses a medical clinical imaging diagnosis instrument, and relates to the technical field of medical equipment. The medical clinical imaging diagnosis instrument comprises a platform, an operation box and supports; the lower surface of the platform is fixedly connected with the supports; the upper surface of the platform is provided with a soft cushion; the upper surface of the soft cushion is provided with a pillow; a second sliding groove is formed in the upper surface of the platform; the second sliding groove is located at one side of the soft cushion; the interior of thesecond sliding groove is glidingly connected with a sliding seat; and the upper surface of the sliding seat is rotatably connected to a lifting seat. According to the medical clinical imaging diagnosis instrument, by using an air cylinder, a first sliding groove, a motor, a worm shaft and the second sliding groove, a scanning device can be adjusted in the front-back direction and the left-right direction when conducting X-ray scanning on a human body, so that the scanning range is broadened; by using the sliding seat and the lifting seat, the scanning device can rotate along the sliding seat;the scanning device can be rotated to one side of the platform when the instrument is idle; and the scanning device can be rotated to the position above the platform when the instrument is used, so that the space is reasonably utilized; and by using steps, climbing of a patient can be facilitated, and convenience is provided.

The invention provides a clinical teaching method and system based on lung clinical images, and relates to the technical field of clinical teaching. The method comprises the steps: S1, obtaining plane images of a plurality of lung clinical images, and recording the plane images as a first image set; S2, constructing a lung three-dimensional model according to the plane images in the first image set; S3, acquiring clinical teaching information, converting the information into annotation information which comprises part information; S4, adding labeling information to a position, corresponding to the part information, on the lung three-dimensional model in a label form; and S5, displaying the lung three-dimensional model with the label to a user through AR equipment or VR equipment. According to the invention, the lung three-dimensional model is established, and the information of each part of the lung is interactively displayed, so that a better clinical teaching effect is achieved.

The invention discloses a microwave CT device. A certain part of a measured object is scanned according to the level with a certain thickness by microwave; a detector receives and detects a permeability value mu and an attenuation value alpha of the microwave passing through the level of an organism; an analogue / digital converter converts the permeability value mu and the attenuation value alpha into numbers, inputs the numbers into a computer system, and performs storage computation and processing on the collected information data obtained by scanning, that is the selected level is divided into a plurality of voxels with the same volume; the dielectric constant epsilon and the conductivity rho of each voxel obtained by calculating are arranged into a matrix, and are stored in a magnetic disk or an optical disk; each number in the number matrix is converted into small blocks with different gray levels from black to white, namely pixels, by a comparison enhancer and a digital / analogue converter, and the blocks are arranged in a matrix manner, namely a number matrix; a microwave CT image is formed after the number matrix is processed. According to the microwave CT device disclosed by the invention, the resolution capacity is high and the image is not damaged; the microwave CT device has high safety, low cost, easiness in popularization and high adaptability, and can be widely applied to medical clinical imaging and other fields.

The invention provides a skin pigment lesion treatment effect image processing method based on feature segmentation, and the method is characterized in that skin pigment lesion color images in the same region before and after treatment are processed through the steps S1 to S5: S1, converting the color images into three-channel RGB gray images; S2, coarsely extracting a focus area; S3, carrying out a repairing and closing operation; s4, calculating to obtain an area with uneven illumination of the picture; s5, low-pass filtering processing is carried out, and an actual focus area distribution map is obtained; and S6, establishing a treatment effect image evaluation model. According to the method, the focus area is segmented, the ROI area is extracted, the background light intensity of the segmented area of the image is eliminated, and the problem of background light influence in the shooting process is solved. The practical work of clinical image analysis is guided to a great extent, and a facial pigment lesion recording, analyzing and evaluating technology with high practicability is provided.

The invention provides a preparation method of a bone defect repair stent, which comprises the following steps of: obtaining imaging data of a bone defect part through modes of clinical imaging CT (Computed Tomography), MRI (Magnetic Resonance Imaging) scanning and the like, then modeling by utilizing CAD (Computer Aided Design) software according to the specific form of the bone defect of a patient, outputting an STL (Standard Template Library) format file of the bone tissue repair stent, and carrying out A biodegradable material photocuring polycaprolactone is used as a printing raw material, a photoetching 3D printer is used for stacking and forming the material, and the porous bone repair scaffold suitable for the form of a defected part of a patient is printed. And grafting the biotinylated vesicles to the surface of the scaffold by using a biotin-avidin system to construct the bioactive scaffold with the surface loaded with the stem cell vesicles. According to the invention, the stem cell vesicles are loaded on the photocuring printed porous bone scaffold by using a biotin-avidin system, so that the personalized customization of the bone scaffold can be realized, and the scaffold has the effect of accelerating bone defect repair by using active substances in the stem cell vesicles.

Magnetic Resonance Imaging (MRI), which is given the acronym ULTRA (Unlimited Trains of Radio Acquisitions), can eliminate magnetic gradient reversals and allow simultaneous MR signal acquisition from the entire object volume in each of a multitude of very small receiver coils arranged in a 3D array around the imaging volume. This permits a rate of MR signal acquisition that is greatly increased (e.g. 256 times) compared with existing techniques, with a full 3D image constructed in as little as 1 millisecond. Furthermore, noise—both audible and electrical—is substantially reduced. The advantages over conventional MRI include:1. Clinical imaging can be completed in seconds, with good signal-to-noise ratio;2. Signal-to-noise ratio is further increased by eliminating RF noise due to gradient switching;3. Real-time functional MRI is possible, on millisecond timescales;4. With single breath holds, high quality imaging of thorax and abdomen is possible.5. ULTRA greatly reduces audible noise and vibration.

The present invention provides rotenone analogs and methods of making and using them. Labeled with single photon and positron emitting isotopes, the rotenone analogs of the present invention are useful in, for example, clinical imaging applications as tracers to measure cardiac blood flow and detect regions of ischemia.

The invention relates to the field of medical services, and discloses a sky shadow radiodiagnosis system. The system comprises an X-ray machine, a spiral CT machine, a nuclear magnetic resonance system and a community interaction terminal which are arranged in a community, and a remote control and transmission module and an in-hospital interaction terminal which are arranged in a hospital; the X-ray machine, the spiral CT machine and the nuclear magnetic resonance system are separately in communication connection with the remote control and transmission module; and the community interaction terminal is in communication connection with the in-hospital interaction terminal. According to the invention, the hospital interaction terminal and the community interaction terminal are utilized to realize communication between hospital medical personnel and patients or family members of the patients, and a medical worker controls the X-ray machine, the spiral CT machine or the nuclear magnetic resonance system installed in the community to scan diseased parts of a patient through the remote control and transmission module so as to obtain clinical image data for diagnosis. The system ensures that fixed population around the community and floating personnel passing through the system can obtain first-time diagnosis and pre-hospital first aid due to emergencies, and brings precious time forlife saving.

A head coil apparatus for MRI of a person's head includes a transmit coil array device generating RF fields for spin state excitation to the head, wherein the transmit coil array device comprises multiple transmit coil loops decoupled from each other and arranged on a transmit coil array carrier surrounding an inner head coil space for receiving the head; a receive coil array device for receiving RF resonance signals from the head; a RF shield surrounding the transmit coil array device and the receive coil array device; and a head coil window providing a viewing port through the RF shield and transmit coil array device. The head coil window has a longitudinal extension and an azimuthal extension, the transmit coil loops includes a window coil loop surrounding the head coil window, and the coil loop is decoupled from a neighbouring transmit coil loop by sharing a common loop conductor.

The invention provides an operation navigation system based on a mobile DR image. The operation navigation system comprises a data processing module, a preoperative operation planning module, a registration fusion module, an operation real-time guiding module and mobile DR equipment. The data processing module is connected with the preoperative operation planning module, and the registration fusion module is connected with the preoperative operation planning module, the mobile DR device and the operation real-time guiding module. The data processing module is used for acquiring a preoperative medical image, performing three-dimensional rendering according to the preoperative medical image, and establishing a three-dimensional visual virtual human body structure chart; the preoperative operation planning module is used for generating at least one operation path according to the virtual human body structure chart and embedding the operation path into the virtual human body structure chart; the mobile DR equipment is used for collecting an intraoperative medical image; the registration fusion module is used for establishing a mapping relation among a clinical image coordinate system, a mobile DR system coordinate system and an optical positioning coordinate system; and the operation real-time guiding module is used for observing the operation process in real time through the target medical image.

The invention provides a method for quantifying and extracting image texture characteristics of vascular wall and is used for early recognition and diagnosis of vascular wall pathological changes. The method includes steps of acquiring vascular wall images of multiple continuous frames by means of a medical imaging system; selecting an inner membrane-intermediate membrane layer of the vascular wall as an interested area from the vascular wall images of each frame, extracting texture characteristic values of the interested area, and acquiring average value of the texture characteristics values; and computing and analyzing the texture characteristic values and establishing a texture characteristic parameter group used for early recognition and diagnosis of the vascular wall pathological changes. The method for quantifying and extracting image texture characteristics of the vascular wall is capable of extracting the texture characteristic values of the vascular wall in any interested area, is beneficial to accurate positioning of pathological changes during pathological changes detection of the vascular wall, high in applicability, free of hardware upgrading in existing clinical imaging system, low in cost, easy to accept by hospitals and doctors and convenient to clinically popularize.