The invention discloses a two-stage sandwich type traveling wave piezoelectric centrifugal pump and a driving method thereof. The two-stage sandwich type traveling wave piezoelectric centrifugal pumpcomprises a base, a stator, a shell, an upper rotor, a lower rotor, a connecting shaft, a forward-closed impeller, a reverse-closed impeller, a first connecting pipe fitting, a second connecting pipefitting and four piezoelectric ceramic modules. During work, the four piezoelectric ceramic modules are excited to drive a particle on the inner side of annular teeth to perform micro-amplitude elliptical motion, the upper rotor and the lower rotor are driven to further drive positive and negative closed impellers to rotate in the same direction, fluid obtains energy for the first time through thelower closed impeller, and then enters the upper closed impeller through a pipeline to obtain energy for the second time, so that the fluid is pressurized twice. The bending type contraposition laminating suction device is simple and compact in structure, easy to seal and miniaturize, capable of accurately controlling flow, fast in response, low in noise, free of electromagnetic interference andelectromagnetic interference, and capable of powering off and self-locking; and compared with a conventional piezoelectric pump, the piezoelectric pump has the advantages of large flow and large output fluid pressure.