The invention relates to a calcium phosphate ceramic active scaffold capable of regulating and controlling cell adhesion performance. According to the method, the calcium phosphate micro-nano active coating is individually designed on the surface of the calcium phosphate biological ceramic scaffold, so that the adhesion behavior of cells is accurately regulated and controlled, and the repair process of tissues is regulated and controlled. According to the preparation method, the calcium phosphate ceramic bracket can be obtained through processes such as 3D printing, a foaming method and a tabletting method, and the surface calcium-phosphorus micro-nano active coating is obtained through processes such as hydrothermal treatment, mineralization and electro-deposition. The design accurately acts on the adhesion protein of the cells at the micro-nano level, so that the change of the cell adhesion behavior is realized. According to the invention, the regulation and control effects of the material on adhesion, activity, proliferation and differentiation of cells are obviously enhanced, and the material has higher hydrophilicity, protein adsorbability, stem cell collection and tissue repair promotion capabilities.