620 results about "Polymer nanoparticle" patented technology

The present invention provides polymer nanoparticles with a controlled architecture of nano-necklace, nano-cylinder, nano-ellipsoid, or nano-sphere. The polymer nanoparticle comprises a core polymerized from multiple-vinyl-substituted aromatic hydrocarbons, a shell polymerized from alkyl-substituted styrene, and a polystyrene layer between the core and the shell. The present invention also provides a method of preparing the polymer nanoparticles and a rubber article such as a tire manufactured from a formulation comprising the polymer nanoparticles.

The present invention relates to polymeric nanoparticles, particularly useful in drug and agent delivery, as well as for imaging and diagnosis. The polymeric nanoparticles of the present invention comprise cross-linkers that, when degraded, leave simple linear polymeric molecules that can be excreted by the body. The present invention also relates to methods of producing the polymeric nanoparticles of the present invention, and methods of using them in drug and agent delivery, as well as imaging and diagnosis.

This invention discloses a process for synthesizing a hairy polymer particle which comprises the steps of (1) polymerizing a vinyl aromatic monomer by emulsion polymerization in an aqueous medium to produce core particles, (2) recovering the core particles from the aqueous medium, (3) dispersing the core particles in an organic solvent, (4) adding an organo-lithium compound to the dried core particles in the organic solvent to produce the hairless core initiator, and (5) utilizing the hairless core initiator to initiate the anionic polymerization of a conjugated diolefin monomer in an organic solvent to produce a solution of the hairy polymer particles. The hairy polymer nanoparticles can then be recovered from the organic solvent. These hairy polymer particles are comprised of (1) a core which is comprised of a polymer of a vinyl aromatic monomer and (2) hairs which are polymer chains of a conjugated diolefin monomer, wherein the hairs are covalently bonded to the core. The core is typically spherical in shape, has a diameter of less than 1000 nm, and is comprised of a crosslinked polymer of a vinyl aromatic monomer. The hairy polymer particles of this invention are useful as fillers in rubber compositions used in making articles of manufacture, such as tires, hoses, power transmission belts, windshield wiper blades, and the like.

The present invention describes polymer nanoparticles with a cationic surface potential, in which both hydrophobic and hydrophilic pharmaceutically active substances can be encapsulated. The hydrophilic and thus water-soluble substances are encapsulated in the particle core by co-precipitation through ionic complexing with a charged polymer. Both therapeutic agents and diagnostic agents can be used as pharmaceutically active substances for encapsulation. The cationic particle surface permits stable, electrostatic surface modification with partially oppositely charged compounds, which can contain target-specific ligands for improving passive and active targeting.

Provided is a composition comprising a rubber and a polymer nano-particle comprising a poly(mono-vinyl aromatic) core and a poly(mono-vinyl aromatic-conjugated diene) surface layer, wherein the core of the polymeric nano-particle has a glass transition temperature (Tg) of between about 150° C. and about 600° C. Also provided is a composition comprising at least two (mono-vinyl aromatic-conjugated diene) copolymer rubbers and a polymeric nano-particle comprising a poly(mono-vinyl aromatic) core and a poly(mono-vinyl aromatic-conjugated diene) surface layer; wherein the core of the polymeric nano-particle has a glass transition temperature (Tg) of between about 150° C. and about 600° C., and the poly(mono-vinyl aromatic-conjugated diene) surface layer of the polymeric nano-particle comprises a mono-vinyl aromatic content that is between about 50 percent and about 150 percent that of the mono-vinyl content of one of the (mono-vinyl aromatic-conjugated diene) copolymer rubbers.

The invention discloses a preparation method of a stable superhydrophobic hot liquid coating, and belongs to the technical field of surface coating preparation. According to the preparation method, in an acetone-water mixed system, in the catalytic effect of acid or base, organic silane and nano particles carry out hydrolysis and condensation reactions to obtain organic silane polymer/nano particle compound suspension; then organic resin adhesive is added into the compound suspension, the mixture is evenly mixed and evenly sprayed on the surface of a substrate material, and finally a thermal curing treatment is performed to obtain the stable superhydrophobic hot liquid coating. The prepared coating has an excellent superhydrophobic hot liquid performance, has the advantages of good mechanical stability, chemical stability, and environmental stability, and thus has a good application prospect.

The present invention provides polymeric nanoparticles comprising triblock and optionally diblock copolymer chains. The architecture of the polymeric nanoparticles may be controlled, resulting in nanoparticles having non-spherical shapes. The present invention also provides a method of preparing the polymeric nanoparticles and a rubber article such as a tire manufactured from a formulation comprising the polymer nanoparticles.

The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention.

Disclosed is a novel polymeric nanoparticle adhesive composite including a nanoparticle filler and method for the production thereof. More particularly, the disclosure describes the use of nanoparticle fillers, including a novel halloysite nanoparticle filler which utilizes generally cylindrical or tubular nanoparticles (e.g. rolled scroll-like shape). The filler is effectively employed in a polymer nanoparticle adhesive composite, containing the halloysite nanoparticle or other equivalent naturally occurring nanotubular filler, in which the advantages of the nanoparticle filler are provided (e.g., reinforcement, flame retardant, etc.) while maintaining or improving mechanical performance of the adhesive composite (e.g., adhesive strength and tack)

Provided herein are systems, methods, and compositions for polymer nanoparticles and polymer magnetic nanoparticles. More particularly, the polymer nanoparticles and polymer magnetic nanoparticles are temperature sensitive and responsive to a first temperature.

The invention relates to a self-assembly method of inorganic nano particle hybridization organic membrane. The method comprises steps of: respectively dissolving polycation and polyanion in a dissolvent, preparing to form a membrane casting solution, standing and defoaming; adding inorganic nano particle into a polyanion solution to prepare a polymer nano particle solution; soaking or dynamically filtering polyanion nano particle solution or polycation solution on the surface of a substrate or basal membrane for 10 to 60 minutes to form a thin membrane layer. The substrate or the basal membrane is soaked or dynamically filtered in the polycation solution or polyanion nano particle solution for 10 to 60 minutes; the polyanion nano particle solution reacts with the polycation to form the thin membrane layer; the substrate or the basal membrane is soaked in deionized water, and the membrane surface is rinsed and dried. When the polycation or the polyanion nano particle solution is filtered on the basal membrane, the transmembrane differential pressure thereof is 0.01 to 0.3MPa or minus 0.02 to minus 0.09MPa. The membrane forming method is simple; the thin membrane prepared on the substrate is compact and uniform; the membrane formed on the basal membrane has excellent penetration and vaporization separating property and mechanical strength.

The invention "colloidal nanoscale carriers for active hydrophilic substances and method for producing same" pertains to the field of medical, odontological or hygiene preparations, and is characterized by structures formed by hydrophilic polymers that contain active hydrophilic substances coated with a non-hydrophilic phase and surfactants with affinity for the components, forming an invert emulsion that allows the incorporation and controlled delivery of active hydrophilic substances, conferring properties such as protection against degradation processes, improvement of compatibility with the other components of the formulation in the final product, increase in the availability and/or bioavailability of the active substance in the medium of interest (including improvements in permeation processes in biological materials, reduction of the exposure and volatilization of the active substance in the medium) and controlled release of the active substance(s). The nanoscale carrier obtained by this method, called colloidal nanoscale carrier (NC), can be used in various fields, such as the pharmaceutical field (including dermatology), cosmetics, personal hygiene products, veterinary medicine, agrochemicals and fertilizers, the food industry and the like. The invention proposes a kinetically stable system with an effective nanoscale structure that consists of nanoscale carriers formed by polymers emulsified in a non-aqueous medium in the presence of a surfactant with affinity for the two phases (the dispersion medium and the encapsulating agent). This system is obtained by nanoemulsification of an aqueous phase of hydrophilic polymers emulsified in a non-hydrophilic (lipophilic or silophilic) phase that contains the surfactants, and is characterized by the implementation of two concepts that encompass the generation of an invert nanoscale emulsion and of polymer nanoparticles. The formulation has the novel technical effect of providing a polymer excipient with a nanoscale structure for delivering hydrophilic molecules suspended in a non-hydrophilic phase, which allows controlling the size of the nanoscale particles and modulating colloidal stability by means of process parameters.

The invention relates generally to the treatment and prevention of human cancer and viral diseases. More specifically, this invention relates to development of a new generation of vaccines that rely on eliciting cellular immune responses, specifically induction of cytotoxic T lymphocytes (CTL), against cancer cells and virus-infected cells via administration of a polymeric nanoparticle containing a vaccine comprising a fusion peptide or a modified peptide. Such a fusion peptide is composed of an insertion signal sequence and a peptide derived from a tumor antigen or a viral antigen, which improves antigen presentation and induces CTL with higher efficiency against cancer cells and virus-infected cells. An exemplary peptide utilized in the invention is Mart-1:27-35 peptide.

Compositions and methods are included for preparing a hairy polymeric nanoparticle including first and second shell block polymer arms are at least partially phase-separated and surround a polymeric core. One type of polymeric arm can have a greater polarity than the other type(s) of polymeric arms. A rubber composition including the hairy nanoparticles is also provided.

Disclosed are nanoparticles of a light emissive polymer, comprising nanoparticles of a cyano-substituted poly(arylene vinylene) polymer; and a biocompatible surfactant adsorbed to the surface of the nanoparticles of the polymer, and preparation method thereof, wherein the method comprises: (1) uniformly mixing a dialdehyde monomer represented by a general formula OHC—Ar₁—CHO, a dicyanide monomer represented by a general formula NC—Ar₂—CN, and a liquid surfactant; (2) adding water to the resulting mixture to prepare an aqueous micelle dispersion; and (3) adding a polymerization catalyst to the aqueous micelle dispersion, followed by carrying out colloidal polymerization of the resulting mixture at room temperature under an atmosphere. The nanoparticles of the light emissive polymer of the invention are stabilized with a biocompatible surfactant, so that it can form a stable aqueous dispersion phase, and has particle size and fluorescence efficiency suitable for a biomolecular marker or a cell or in vivo imaging; therefore, it can be used as a cell or in vivo light emission contrast agent.