51 results about "Hairless" patented technology

Hairless protein interacting partner complexes, agonist and / or antagonist compounds, compositions and products comprising same and methods thereof. Hairless protein is indispensable for the beautification and / or improvement of mammalian skin. Therefore, such interacting complexes are useful for screening test compounds for the beautification and / or improvement of mammalian skin.

The present invention provides DNAzymes and ribozymes that specifically cleave Hairless protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The present invention also provides various methods of inhibiting the expression of Hairless Protein. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes and antisense oligonucleotides as active ingredients.

A genetically modified NOD.Cg-Prkdc scid Il2rg tm1Wjl / SzJ mouse is provided by the present invention wherein the genome of the mouse includes a mutated Rhbdf2 gene such that the mouse expresses a mutant iRhom2 protein, wherein the mutant iRhom2 protein differs from wild-type iRhom2 protein due to one or more mutations selected from p.I156T, p.D158N and p.P159L, and wherein the mouse is characterized by hairless phenotype and increased growth of an exogenous tumor compared to a mouse of the same genetic background which express wild-type iRhom2 protein.

The invention provides two dominant molecular marks cosegregation with tuberculate fruit (Tu) gene in cucumbers, wherein the first dominant molecular mark is composed of 236 nucleotides shown in the sequence table SEQ ID NO.1; and the second dominant molecular mark is composed of 468 nucleotides shown in the sequence table SEQ ID NO.2. Both the two dominant molecular marks disclosed by the invention exist in the cDNA areas of the tuberculate fruit (Tu) shown in the sequence table SEQ ID NO.7 and have high stability, and can be applied to the screening of cucumber types (except for the mutant variety g1 without thorns and tubercles) with / without tubercles around the world simply and rapidly and in high throughput. According to the cDNA areas of the tuberculate fruit (Tu) shown in the sequence table SEQ ID NO.7, a plurality of molecular marks can be designed as the dominant molecular marks for the screening of cucumber types (except for the mutant variety g1 without thorns and tubercles) with / without tubercles around the world, and the cDNA areas of the tuberculate fruit (Tu) can lay the molecular foundation for the clone of the glabrous gene and the gloss gene of cucumbers.

The patent of the present invention relates to the detection primer labeled with InDel and its application in the breeding of burr-free Chinese cabbage. The detection primer of Chinese cabbage InDel-labeled TR-1, the detection primer is a pair, the nucleotide sequence of the upstream primer is shown in SEQ ID NO.1, and the nucleotide sequence of the downstream primer is shown in SEQ ID NO.2. The invention discloses for the first time the InDel-marked TR-1 related to the burr of Chinese cabbage and its detection primers. PCR amplification is carried out on the DNA of hairy and hairless Chinese cabbage inbred lines and the F2 generation isolated population material generated by the hybridization of the two. It was detected by 8% denaturing polyacrylamide gel electrophoresis. It was found that the InDel marker TR-1 related to the burr of Chinese cabbage can clearly distinguish between hairy and hairless Chinese cabbage varieties, and can be used for the identification of new hairless Chinese cabbage varieties. breeding.