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128 results about "Dermal papillae" patented technology

In the human skin, the dermal papillae are small, nipple-like extensions of the dermis into the epidermis. At the surface of the skin in hands and feet, they appear as epidermal or papillary ridges. Blood vessels in the dermal papillae nourish all hair follicles and bring nutrients and oxygen to the lower layers of epidermal cells. The pattern of ridges they produce in hands and feet are partly genetically determined features that develop before birth. They remain substantially unaltered throughout life, and therefore determine the patterns of fingerprints, making them useful in certain functions of personal identification. The dermal papillae are part of the uppermost layer of the dermis, the papillary dermis, and the ridges they form greatly increase the surface area between the dermis and epidermis. Because the main function of the dermis is to support the epidermis, this greatly increases the exchange of oxygen, nutrients, and waste products between these two layers. Additionally, the increase in surface area prevents the dermal and epidermal layers from separating from each other by strengthening the junction between them.

Apparatus and Method for Capturing a Vital Vascular Fingerprint

A method using optical coherence tomography to capture the microvascular network of the superficial layer of the finger skin for the purpose of fingerprint authentication and liveness detection. At the dermal papilla region, the vascular pattern follows the same pattern of the fingerprint and this vascular pattern forms a live vascular fingerprint. This live vascular fingerprint provides for ultrahigh security and a unique way for fingerprint-based personal verification. Because the system is based on blood flow, which only exists in a living person, the technique is robust against spoof attaching. After performing non-contact in-vivo imaging of a human fingertip, a three dimensional vasculature image is reconstructed from a plurality of vasculature tomography images and at least one vasculature fingerprint image which corresponds to the fingertip is extracted from the three dimensional vasculature image. This extracted image may then be compared to known fingerprint database for authentication or for liveness detection.
Owner:RGT UNIV OF CALIFORNIA

Humanized cell factor hair agent and preparing method thereof

The invention discloses a human-derived cell-factor germinal preparation and the preparation method, relating to the technical filed of the healthcare product. The invention contains lecithin which is the lipid membrane-forming material, cholesterin and active component germinal cell factor, with the proportion by weight between them being 2-6:1-4:1-5; the lecithin is selected from egg yolk lecithin or soybean lecithin; the germinal cell factor is selected from the albumen freeze-dry powder of the culture supernatant of human fibroblasts, placental cells, cuticle cells or dermal papilla cells, with abundant cell factors for the hair growth in the culture supernatant; the germinal cell factors are enveloped in the lipid membrane. The rotary evaporating method is adopted in the process to make the product the lipidosome medicament form which can easily permeate the skin barrier. In addition, the product is frozen and dried into the more stable powder, which needs only to be dissolved by the distilled water containing 2% penetrating enhancer azone while in use. The invention is of easy penetration, high skin retention and good curative effect and free of side effect.
Owner:何荫良

Tissue-engineered skin containing blood vessels and hair follicle structures based on 3D printing and preparation method thereof

The invention relates to tissue-engineered skin containing blood vessels and hair follicle structures based on 3D printing and a preparation method thereof. The tissue-engineered skin is composed of an epidermal layer, an acellular dermal scaffold and a dermis layer, wherein in the epidermal layer, epidermal stem cells are used seed cells, the seed cells are printed on the upper surface of the acellular dermal scaffold through a 3D printer after being compounded with a hydrogel carrier to differentiate and form a normal epidermal structure, in the dermis layer, mesenchymal stem cells, vascularendothelial cells, dermal papilla cells and adipose-derived stem cells are used as seed cells, the seed cells and a hydrogel carrier are compounded, through the 3D printer, gelatin slow-release micropheres compounded with cytokines are printed on the lower surface of the acellular dermal scaffold, and meanwhile, the hydrogel compound of the seed cells is printed in the gelatin slow-release micropheres to form a dermis structure with a three-dimensional spatial structure.
Owner:SHANXI MEDICAL UNIV

Combination for promoting eyelash growth

The invention relates to a combination for promoting eyelash growth. The combination comprises myristoyl pentapeptide-4, palmitoyl tripeptide-1 and tripeptide-1 copper. The invention further provides an application of the combination. The combination has the advantages of capabilities of activating keratin gene expression of human bodies to generate more keratin, and promoting eyelash growth. Eyelash growth solution prepared by the combination can promote eyelashes to be long and dense and is mild and non-irritating, functional components can rapidly enter hair follicle and skins and reach skin bottoms to activate dermal papilla cells.
Owner:上海波林丝生物科技有限公司

Preparation of artificial skin containing hair follicle and artificial skin prepared by the same

InactiveCN101264344ASolve the problem of difficult sourcePromotes normalized healingProsthesisDermal papillaeRectal epithelium
The invention relates to a preparation method of artificial skin, in particular to a preparation method of artificial skin with hair follicles and the skin made by the method, belonging to biomedical field. The preparation method comprises the following steps: (1) preparing the epithelial cells of the hair follicle; (2) culturing the dermal papilla cells; (3) culturing the artificial skin with hair follicles. The preparation method of artificial skin has the advantages that: (1) the invention originally prepares artificial skin with hair follicles on skin support by hair follicle cells, and reduces the antigenicity greatly compared with the artificial skin made by animal cells; (2) the artificial skin comprises hair follicles, and enable to do physiological functions of skin; (3) the artificial skin is not easy to shrink but easy to absorb; (4) the artificial skin can be used as wound-cover material for large area burn wounded person in clinic and accelerates the wound to heal naturally; (5) the invention resolves the trouble of skin source for large area burn; (6) the preparation method is reasonable in design, convenient in operation and easy in scale production.
Owner:SECOND AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE +1

Protective Compositions for Dermal Papilla Cells

Disclosed are novel protective compositions for dermal papilla cells. In an embodiment the protective compositions of the present invention comprise 0.25% w / w or above of compositions comprising at least 10% w / w and above of 1-O-galloyl-β-D-glucose (β-glucogallin). In an embodiment, the said protective composition additionally comprises 50% to greater than 50% gallates including mucic acid 1,4-lactone 5-O-gallate, mucic acid 2-O-gallate, mucic acid 6-Methyl ester 2-O-gallate, mucic acid 1-Methyl ester 2-O-gallate and ellagic acid. In another embodiment the invention also encompasses synergistic protective compositions comprising the said protective compositions and 0.5% concentrate of liquid endosperm of Cocos nucifera, for dermal papilla directed towards helping the dermal papilla cells to form sufficient numbers and to retain a healthy morphology conducive for hair growth.
Owner:SAMI LABS LTD

Hair growth tonic

A dermal papilla cell growth promoter, a hair growth stimulant and a hair growth tonic containing a compound having an activity of inhibiting the function of WNT-5A.
Owner:TAISHO PHARMACEUTICAL CO LTD

Method and Composition for Thickening Hair

The present invention provides a method for maintaining and promoting hair thickening by increasing the expression of keratinocyte growth factor (FGF-7) in hair follicle cells, and preferably dermal papilla cells, a composition for increasing expression of FGF-7 that contains adenosine and / or a derivative thereof, and particularly, an external scalp preparation for maintaining and promoting hair thickening.
Owner:SHISEIDO CO LTD

Antibodies specific for papillary fibroblasts as markers for skin quality

Whether or not a sample of skin or of a skin equivalent contains such amount of a papillary fibroblast population as to be considered a normal skin is determined by labelling said skin or skin equivalent with at least one antibody specific for papillary fibroblasts and evaluating the extent of such labelling as a marker for skin or skin equivalent quality.
Owner:LOREAL SA

Cell Compositions and Methods for Hair Follicle Generation

InactiveUS20110305671A1Improve scalabilityStraightforward and efficient and high outputBiocidePeptide/protein ingredientsCuticleStromal cell
The application describes a method of generating a hair follicle, comprising administering a composition comprising epidermal matrix cells, dermal papilla cells, dermal sheath cells and outer root sheath cells to the scalp of a mammal. The composition may optionally be administered with a hair growth agent and / or a carrier. The application also describes a composition comprising epidermal matrix cells, dermal papilla cells, dermal sheath cells and outer root sheath cells and the use of the composition to generate hair follicles.
Owner:ALVIA FZE

Identity markers

Methods for identifying trichogenic dermal cells, including dermal papilla cells and dermal sheath cells, capable of inducing hair follicle formation when injected into skin are provided. It has been discovered that EGF latrophilin and seven transmembrane domain-containing protein 1 (ELTD1). Transmembrane Protein 108 (TMEM1 08), Hyaluronan and proteoglycan link protein 1 (HAPLN1) are biomarkers that can be used to detect, identify, and distinguish trichogenic dermal cells, i.e., that are able to induce hair follicle formation, from other skin cells. Populations of skin cells enriched with trichogenic dermal cells can be produced by selecting for and enriching for dermal cells that express ELTD1, TMEM1 08, HAPLN1, or a combination thereof.
Owner:ADERANS RES INST

Injection capable of treating androgenetic alopecia with dermal papilla cell exosomes

The invention relates to an injection capable of treating androgenetic alopecia with dermal papilla cell exosomes. The injection is a normal saline solvent containing dermal papilla cell exosomes. A preparation method of the injection comprises fiver steps including dermal papilla cell separation, dermal papilla cell adherent culture, dermal papilla cell stimulation induced culture, exosome freezedried powder preparation, and injection preparation. The amount of the exosomes secreted by the dermal papilla cells prepared using the preparation method is large, the content of effective components capable of promoting hair regeneration is high, and the treatment effect of the injection on androgenetic alopecia is excellent.
Owner:浙江卫未生物医药科技有限公司

Hair growth method

A method of enabling effective hair growth and furthermore, inducing hair growth closely similar to the natural hair state in the case of transplanting dermal papillae or cultured dermal papilla cells into the skin to regenerate the hair, characterized by comprising transplanting a composition containing the following components into an epidermis defect site: (a) dermal papillae or dermal papilla cells, (b) an epidermal tissue or epidermal cells and / or (c) a tissue constituting hair follicles or cells thereof.
Owner:BIOINTEGRENCE +1

Method for promoting hair growth or hair regeneration by maintaining or increasing expression of cell-adhesion factor

An object of the present invention is to promote hair growth or hair regeneration by promoting formation and / or regeneration of hair follicles. A method is provided for promoting formation and / or regeneration of hair follicles, comprising maintaining or increasing expression of one or a plurality of genes involved in cell adhesion in dermal papilla cells.
Owner:SHISEIDO CO LTD

Hair growth inducer

InactiveCN106138058AReduces symptoms associated with shedding diseaseImprove regenerative abilityOrganic active ingredientsCosmetic preparationsDiseaseTofacitinib
The invention discloses a hair growth inducer, which comprises an active ingredient composed of tofacitinib and minoxidil with a mass percentage of 0.1:99.9-99.9:0.1. The hair growth inducing agent provided by the invention, its active ingredient comprises tofacitinib and minoxidil, wherein tofacitinib is a kind of JAK inhibitor, can interact with target cells (such as dermis, epidermis, dermal papilla cells or hair follicles) Cell) specific protein active site selectively binds, inhibits the transmission of cell pathway signals and the synthesis of characteristic cytokines, thereby reducing the symptoms associated with hair loss diseases; Minoxidil is a potassium ion channel opener that can directly relax Vascular smooth muscle has a powerful dilation effect on small arteries, reduces peripheral resistance, promotes the growth of hair follicle cells, and thus regenerates hair; the combination of these two substances synergistically acts on the target protein of target cells and vascular smooth muscle, and inhibits cytokines Synthesis and accelerated blood circulation, in order to achieve a significant effect of promoting hair regeneration.
Owner:颜晓丽

Composition for Preventing and Treating Alopecia Disorder Containing Morgalanthamine Compounds as an Active Ingredient

InactiveUS20120129838A1Preventing and treating alopecia disorderEffective preventionCosmetic preparationsBiocideDermal papillaeActive ingredient
Provided are a pharmaceutical composition, a cosmetic composition and health foods for preventing and treating alopecia disorder, which include a norgalanthamine compound as an active ingredient. Since the norgalanthamine compound has an effect on growth and proliferation of dermal papilla cells that play an important role in hair growth, the norgalanthamine compound may be used for the pharmaceutical composition, the cosmetic composition and health foods, which are useful in preventing and treating alopecia disorder.
Owner:IND ACADEMIC COOPERATION FOUND JEJU NAT UNIVERSTIY +1

Method for promoting hair growth or hair regeneration by maintaining or increasing expression of cell-adhesion factor

An object of the present invention is to promote hair growth or hair regeneration by promoting formation and / or regeneration of hair follicles. A method is provided for promoting formation and / or regeneration of hair follicles, comprising maintaining or increasing expression of one or a plurality of genes involved in cell adhesion in dermal papilla cells.
Owner:SHISEIDO CO LTD

Application of hair follicle stem cell-derived exosome in promoting hair follicle stem cell proliferation and differentiation into hair follicle cells

The invention discloses application of a hair follicle stem cell-derived exosome in promoting hair follicle stem cell proliferation and differentiation into hair follicle cells. It is found that the exosome derived from the hair follicle stem cells can enter recipient cells, and can promote proliferation of the hair follicle stem cells and dermal papillae cells, wherein the hair follicle stem cell-derived exosome stimulated by melatonin has a more obvious effect of promoting hair follicle stem cell proliferation. It is further found that the hair follicle stem cell-derived exosome can promotemigration of hair follicle stem cells and dermal papillae cells, and the migration promoting effect of the melatonin-stimulated hair follicle stem cell-derived exosome is more obvious. The hair follicle stem cell-derived exosome can promote the expression of hair follicle development-related genes of hair follicle stem cells and dermal papillae cells so as to promote the differentiation of the hair follicle stem cells into the hair follicle cells, and the melatonin-stimulated hair follicle stem cell-derived exosome has a more obvious effect of promoting the proliferation and differentiation ofthe hair follicle stem cells.
Owner:INNER MONGOLIA AGRICULTURAL UNIVERSITY

Composition for preventing hair loss or promoting hair growth, containing ginseng-derived exosome-like vesicles

Disclosed in the present specification are: a composition for preventing hair loss or promoting hair growth, containing ginseng-derived exosome-like vesicles; and a method for preparing the composition. The ginseng-derived exosome-like vesicles can have a diameter of 20-500 nm and can be isolated from ginseng root. The composition contains ginseng-derived exosome-like vesicles as active ingredients, thereby having an effect of inducing hair growth by activating dermal papilla cells (DPCs).
Owner:AMOREPACIFIC CORP

Method and device for removing hair

A method of treating unwanted hair is disclosed. The method comprises: transmitting acoustic waves through the hair so as to generate heat at a follicle, a dermal papilla, a hair bulge and / or a germinal matrix of the hair. The heat itself is sufficient to damage or destroy the follicle, the dermal papilla, the hair bulge and / or the germinal matrix.
Owner:APPLISONIX

Creation of hair follicles in tissue-engineered skin grafts

A living tissue-engineered skin graft having a potential to develop hair follicles includes a multilayered skin-like structure of alternating nanofiber mats and layers of fibroblasts assembled in a layer-by-layer fashion. Aggregates of dermal papilla capable of developing into hair follicles are embedded in the multilayered structure such that the aggregates develop into hair follicles upon culturing the multilayered structure. Keratinocytes are provided as an outer layer of the skin graft. Fibroblasts, keratinocytes and dermal papilla cells are isolated from skin and cultured to form suspensions of cells for fabricating the skin graft. Aggregates of dermal papilla cells are generated using a hanging drop method. Nanofiber mats are formed by electrospinning biocompatible materials onto a culture media or a layer of fibroblast suspension. The skin graft has dermal and epidermal layers and provides a biomimetic environment to promote healing and hair growth.
Owner:STEVENS INSTITUTE OF TECHNOLOGY

Methods for restoring dryness or proliferative ability of hair follicle-derived cells

The invention discloses a method for restoring the dryness or proliferative ability of hair follicle-derived cells, comprising the following steps: cutting umbilical cord with removed arteries and veins, culturing by adding a low-sugar DMEM culture solution containing bovine serum and penicillin-streptomycin, and carrying out subculture by trypsinization when mesenchymal stem cell fusion reaches 70-80%; continuously culturing by replacing a medium without exosome serum when the cells are passaged to the 3rd to 5th generation and cell fusion reaches 60-80%; extracting by a ultracentrifugation method to obtain exosomes of mesenchymal stem cells; carrying out isolated culture on dermal papillae cells by an improved two-step enzymatic method; and culturing the obtained dermal papillae cells ina DEME basal medium, which contains PDGF, KGF, VEGF and exosomes of mesenchymal stem cells. The method of the invention can effectively restore the dryness of hair follicle-derived cells, and regulates the normal physiological metabolism of hair follicle cells by secreting various regulatory factors, thus solving the problem of alopecia from the perspective of hair follicle physiology.
Owner:浙江卫未生物医药科技有限公司

Hair growth method

A method of enabling effective hair growth and furthermore, inducing hair growth closely similar to the natural hair state in the case of transplanting dermal papillae or cultured dermal papilla cells into the skin to regenerate the hair, characterized by comprising transplanting a composition containing the following components into an epidermis defect site: (a) dermal papillae or dermal papilla cells, (b) an epidermal tissue or epidermal cells and / or (c) a tissue constituting hair follicles or cells thereof.
Owner:YOSHIZATO KATSUTOSHI +3

Pharmaceutical compositions for promoting hair follicle regeneration and methods for preparing the same

Pharmaceutical compositions for promoting hair follicle regeneration and their respective preparation methods are provided to overcome the ineffectiveness and low efficiency of the conventional hair follicle regeneration techniques. The methods for preparing the pharmaceutical compositions for promoting hair follicle regeneration include seeding dermal papilla cells and adipocyte lineage cells on a culture material in order for the dermal papilla cells and the adipocyte lineage cells to jointly assemble cell spheres. The pharmaceutical compositions can effectively enhance the effect and efficiency of hair follicle regeneration and thereby promote the regeneration of hair follicles.
Owner:NAT CHENG KUNG UNIV +1

Preparation method of cell suspension for promoting hair regeneration and preventing alopecia

The invention discloses a preparation method of a cell suspension for promoting hair regeneration and preventing alopecia. According to the method, scalp epidermal cells and dermal papilla cells are separated from scalp tissues, and the scalp epidermal cells and the dermal papilla cells are subjected to multiplication culture to prepare the cell suspension for preparing an injection for treating androgenic alopecia, and the injection is derived from patients without immune rejection reaction, has good cell activity, strong regeneration capability and high effective rate for treating the androgenic alopecia; and moreover, the injection can be prepared only by taking a small amount of scalp tissues, and the transplantation efficiency is high.
Owner:JINAN PANSHENG BIOTECH
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