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45 results about "Microvascular Network" patented technology

System for assessing the efficacy of stored red blood cells using microvascular networks

A system for assessing the microvascular fitness of a sample of stored red blood cells. The system has a network device having at least one network unit. The network unit has a single inlet and a single outlet for the sample and a plurality of microchannels. The plurality of microchannels receive the sample from the single inlet and drain the sample into the single outlet. The network unit includes an aspiration pressure means for providing movement of liquid sample through the at least one network unit. The system further includes an analysis unit that receives the network device therein. The analysis unit includes a sensor for capturing measurements related to the sample and a processor capable of comparing the captured measurements to measurements stored in a database of healthy red blood cells to determine the microvascular fitness of the stored red blood cells.
Owner:TRUSTEES OF BOSTON UNIV

Three-Dimensional Microfabricated Bioreactors with Embedded Capillary Network

In an aspect, the present invention uses projection micro stereolithography to generate three-dimensional microvessel networks that are capable of supporting and fostering growth of a cell population. For example, provided is a method of making a microvascularized bioreactor via layer-by-layer polymerization of a photocurable liquid composition with repeated patterns of illumination, wherein each layer corresponds to a layer of the desired microvessel network. The plurality of layers are assembled to make a microvascular network. Support structures having different etch rates than the structures that make up the network provides access to manufacturing arbitrary geometries that cannot be made by conventional methods. A cell population is introduced to the external wall of the network to obtain a microvascularized bioreactor. Provided are various methods and related bioreactors, wherein the network wall has a permeability to a biological material that varies within and along the network.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS

Microvascular network device

A microvascular network device comprising: a substrate; at least one microchannel; at least one opening to the microchannel for sample entry; at least one opening to the microchannel for sample exit; and an aspirator which causes the sample to traverse the microchannel.
Owner:HEMANEXT +1

Repairing or replacing tissues or organs

In general, this invention provides methods and compositions for stabilizing, repairing, or replacing damaged or diseased tissues or organs by engineering blood vessels in such tissues or organs. In addition, the invention further provides methods and compositions for producing functional microvascular networks useful in tissue engineering.
Owner:THE GENERAL HOSPITAL CORP

Method for Creating Perfusable Microvessel Systems

A method for creating networks of perfusable microvessels in vitro. A mandrel is drawn through a matrix to form a channel through the matrix. Cells are injected into the channel. The matrix is incubated to allow the cells to attach inside the channel. The channel is perfused to remove unattached cells to create a parent vessel, where the parent vessel includes a perfusable hollow channel lined with cells in the matrix. The parent vessel is induced to create sprouts into the surrounding matrix gel so as to form a microvessel network. The microvessel network is subjected to luminal perfusion through the parent vessel.
Owner:NORTIS

Method for creating perfusable microvessel systems

A method for creating networks of perfusable microvessels in vitro. Cells including cell types capable of sprouting are seeded 1300 into a channel in a matrix at to activate competency 1304 of the cells for sprouting as microvessels based on the seeding density. The matrix channel is perfused with medium to allow parent vessels to form and for viability 1324. The parent vessels and matrix are incubated and perfused to provide for sprouting of microvessels from parent vessels into the surrounding matrix 1328. The sprouting parent vessels are grown until network forms 1332.
Owner:NORTIS

In-vitro construction method for simulating blood brain barrier through human brain microangiogenesis

The invention discloses an in-vitro construction method for simulating a blood brain barrier through human brain microangiogenesis. The method comprises the following steps: preparing human brain microvascular endothelial cell suspension and human astrocyte suspension, and preparing fibrinogen mother liquor and thrombin mother liquor; mixing the endothelial cell suspension, the astrocyte suspension, a DMEM (Dulbecco's Modified Eagle Medium) medium, the fibrinogen mother liquor and the thrombin mother liquor, and preparing a mixed cell gel solution; injecting the mixed cell gel solution into amicro-fluidic chip, performing thermostatic incubation to gelation, adding an endothelial growth medium into the micro-fluidic chip, and constructing a 3D cell culture chip; performing continuous culture on the 3D cell culture chip, and enabling the endothelial cells and astrocyte to grow into a brain microvascular network structure, namely correspondingly producing the simulated blood brain barrier. According to the technical scheme provided by the invention, the in-vitro model of the blood brain barrier is successfully constructed, and the characteristics of the blood brain barrier are clearly and accurately reflected.
Owner:WUHAN CHOPPER BIOLOGY

Cycle pathway micro-vessel network structure and application thereof

ActiveCN102745323ASolve the problem of sharp decrease in stiffnessStrong load bearing capacityFuselage bulkheadsWorking fluidEngineering
The invention relates to a cycle pathway microvascular network structure and an application thereof. The network structure comprises cycle pathway micro-vessels, the cycle pathway micro-vessels have a multi-array penetrating type structure or a three-dimensional penetrating type structure, the structure is in a thermotropic shape memory polymer matrix, the communication ports at the ends of the micro-vessel networks are preset outside the shape memory polymer matrix, and a work fluid flows through the whole cycle networks through the communication ports at the ends of the micro-vessel networks. The cycle pathway micro-vessel network structure is applied to the thermotropic shape memory polymer. The network structure has the advantages of high heating efficiency, uniform heating and simple technology, and solves a problem that the rigidity of the shape memory polymer rapidly reduces at a glass transition temperature. The network structure enables the shape memory polymer to be effectively heated and simultaneously guarantee that the shape memory polymer has a certain rigidity and a certain strength to oppose a certain load, so the load bearing capability of the shape memory polymer is substantially improved, and application fields of the shape memory polymer are extended.
Owner:HARBIN INST OF TECH

Bionic pre-vascularization material as well as preparation method and application thereof

The invention relates to the technical field of biological medicines, and discloses a bionic pre-vascularization material as well as a preparation method and application thereof. The preparation method of the pre-vascularization material comprises the steps of preparing a biological material with a vein structure, performing in-vitro cell culture and performing in-vivo transplantation. The pre-vascularization material can be applied to preparation of a wound repair material, a scaffold material, an organ reconstruction material, a tissue replacement material, a tissue filling material or a wrapping material and the like. A vein network structure of a pre-lymphatic vascularization material is similar to a lymphatic network structure of the human body; and a mesh branch structure of the leafvein of the pre-vascularization material is similar to a microvascular network structure of the human body. The bionic pre-vascularization material has the mechanical properties suitable for expectable application and can keep sufficient integrity until tissues grow inwards and heal; and the bionic pre-vascularization material has the characteristic of being easily processed and shaped into a product and the acceptable storage life, but does not cause significant inflammatory or toxic response in vivo.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV

Blood brain barrier injury assessment device and method based on dual-wavelength photoacoustic microscopic imaging

The invention discloses a blood-brain barrier injury assessment device and method based on dual-wavelength photoacoustic microscopic imaging, and the device and mehtod are used for realizing high-resolution three-dimensional real-time assessment of blood-brain barrier injury. The device comprises a laser source assembly, a light beam transmission assembly, a light beam scanning assembly, a reflective imaging port assembly, a signal acquisition assembly and a computer. The method comprises the following steps: establishing a blood-brain barrier injury model; injecting a photoacoustic nanoparticle suspension into the blood of the established model through femoral vein; adopting a dual-wavelength photoacoustic microscopic imaging mode to conduct high-resolution brain imaging on the established model to obtain photoacoustic data, wherein pulse laser of a first wavelength and pulse laser of a second wavelength are used for exciting hemoglobin and nanoparticles respectively; reconstructing the photoacoustic data to obtain a capillary network structure of the brain and a distribution condition of nano particles; and identifying the damage area of the blood brain barrier according to the distribution condition of the nano particles on the outer side of the blood vessel, calculating the concentration of the nano particles outside the blood vessel, and analyzing the damage degree quantitatively.
Owner:SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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