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Hair growth inducer

A hair growth and inducer technology, applied in hair care, cosmetics, skin diseases, etc., can solve the problem that the effect of hair regeneration is not very obvious, and achieve the effect of strong small artery dilation, promote hair regeneration, and promote growth

Inactive Publication Date: 2016-11-23
颜晓丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent 201310563564.1 discloses that sialic acid is used as an active ingredient to prepare hair growth shampoo; patent 201510190767.X discloses that ultra-high molecular weight γ-polyglutamic acid is used as an active ingredient to prepare shampoo for preventing hair loss and promoting hair growth; these disclosed patent technologies Although it has a certain anti-hair loss effect, the effect of promoting hair regeneration is not very obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh 2.5g of tofacitinib citrate salt and 2.5g of minoxidil nitrate free base and mix evenly, add to 100g of glycerol and water according to the mixed solvent composed of any mass ratio, stir at 25°C to dissolve the active After combining the ingredients, a hair growth inducer for external application is obtained.

Embodiment 2

[0017] Weigh 0.1g of tofacitinib free base tartrate and 9.9g of minoxidil sulfate salt and mix evenly, add to 999g of water solvent, stir and dissolve the active ingredient at 25°C to obtain the hair growth inducer for external application or oral administration .

Embodiment 3

[0019] Weigh 9.9g of tofacitinib malate salt and 0.1g of minoxidil hydrochloride salt, mix uniformly, add into 900g of shampoo, stir and dissolve the active ingredient at 25°C to obtain the hair growth inducer for external use.

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PUM

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Abstract

The invention discloses a hair growth inducer, which comprises an active ingredient composed of tofacitinib and minoxidil with a mass percentage of 0.1:99.9-99.9:0.1. The hair growth inducing agent provided by the invention, its active ingredient comprises tofacitinib and minoxidil, wherein tofacitinib is a kind of JAK inhibitor, can interact with target cells (such as dermis, epidermis, dermal papilla cells or hair follicles) Cell) specific protein active site selectively binds, inhibits the transmission of cell pathway signals and the synthesis of characteristic cytokines, thereby reducing the symptoms associated with hair loss diseases; Minoxidil is a potassium ion channel opener that can directly relax Vascular smooth muscle has a powerful dilation effect on small arteries, reduces peripheral resistance, promotes the growth of hair follicle cells, and thus regenerates hair; the combination of these two substances synergistically acts on the target protein of target cells and vascular smooth muscle, and inhibits cytokines Synthesis and accelerated blood circulation, in order to achieve a significant effect of promoting hair regeneration.

Description

technical field [0001] The invention relates to the field of fine chemicals, in particular to a hair growth inducer. Background technique [0002] Hair loss is a common dermatological disease. With the accelerated pace of people's life and work, the health index issued by the relevant state departments shows that the incidence rate has reached 30%. There are many reasons for hair loss, which can generally be divided into androgenetic alopecia, neurogenic alopecia, endocrine alopecia, and symptomatic alopecia. At present, the effective methods for treating hair loss and promoting hair regeneration are very limited, and the general methods are taking clinical drug therapy and physical surgery for hair transplantation. These treatments are not only expensive but also bring a lot of inconvenience to patients. [0003] Incorporating effective ingredients for treating hair loss into a shampoo for daily use, the method of treating hair loss and promoting hair growth is not only c...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K31/506A61P17/14A61K8/49A61Q5/02A61Q5/12
CPCA61K31/519A61K8/4953A61K31/506A61Q5/02A61Q5/12
Inventor 颜晓丽
Owner 颜晓丽
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