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Pharmaceutical composition for treating alopecia

A hair loss and drug technology, which is applied in the field of drug combination for treating hair loss, can solve the problems that the effect of hair regeneration is not very obvious, not very obvious, and the side effects of minoxidil are large.

Pending Publication Date: 2021-11-30
南京帝昌医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN107847428A discloses using tofacitinib citrate as a medicine for treating alopecia, but it has a certain effect on treating alopecia through experiment comparison as a single component, but it is still not very obvious; patent 201510190767. High-molecular-weight γ-polyglutamic acid is used as an active ingredient to prepare shampoos that prevent hair loss and promote hair growth; although these disclosed patented technologies have certain anti-hair loss effects, the effect of promoting hair regeneration is not very obvious.
Patent CN106138058A discloses the composition of tofacitinib and minoxidil, the effect is relatively good, but because the side effects of minoxidil are relatively large, so the clinical application has certain limitations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Prescription: tofacitinib citrate 5g, cyclosporin 10g, propylene glycol 100ml, ethanol 300ml, phenoxyethanol 1g, add water to 1000ml, operation steps: weigh the prescribed amount of tofacitinib citrate, cyclosporine Bacterin, add the prescribed amount of propylene glycol and ethanol and stir to dissolve completely, add purified water to 1000ml.

Embodiment 2

[0017] Prescription: tofacitinib citrate 10g, cyclosporin 10g, propylene glycol 100ml, ethanol 300ml, phenoxyethanol 1g, add water to 1000ml, operation steps: weigh the prescribed amount of tofacitinib citrate, cyclosporine Bacterin, add the prescribed amount of propylene glycol and ethanol and stir to dissolve completely, add purified water to 1000ml.

Embodiment 3

[0019] Prescription: tofacitinib citrate 15g, cyclosporine 10g, propylene glycol 100ml, ethanol 300ml, phenoxyethanol 1g, add water to 1000ml, operation steps: weigh the prescribed amount of tofacitinib citrate and cyclosporine Bacterin, add the prescribed amount of propylene glycol and ethanol and stir to dissolve completely, add purified water to 1000ml

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Abstract

The invention relates to a pharmaceutical composition for treating alopecia, which is used as a pharmaceutical preparation in the field of treating diseases related to alopecia. The main active ingredients of the composition are tofacitinib and cyclosporin A. Compared with a single ingredient, the composition provided by the invention has the advantages that the effect is better, the effect taking time is short, the grown hair is the same as normal hair, and the hair quality is harder.

Description

technical field [0001] The invention relates to a drug combination for treating alopecia, which is used as a pharmaceutical preparation in the field of treating related alopecia diseases. Background technique [0002] Hair loss is a common dermatological disease. With the accelerated pace of people's life and work, the health index issued by the relevant state departments shows that the incidence rate has reached 30%. There are many reasons for hair loss, which can generally be divided into androgenetic alopecia, neurogenic alopecia, endocrine alopecia, and symptomatic alopecia. At present, the effective methods for treating hair loss and promoting hair regeneration are very limited, and the general methods are taking clinical drug therapy and physical surgery for hair transplantation. These treatments are not only expensive but also bring a lot of inconvenience to patients. [0003] Incorporating effective ingredients for treating hair loss into a shampoo for daily use, t...

Claims

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Application Information

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IPC IPC(8): A61K38/13A61P17/14A61K31/519
CPCA61K38/13A61K31/519A61P17/14A61K2300/00
Inventor 刘小斌胡俊翟洪
Owner 南京帝昌医药科技有限公司
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