236results about How to "Effective composition" patented technology

The present invention is directed to compositions of one or more nanoparticulate active agents, at least one PEG-derivatized surface stabilizer, and at least one antibody or fragment thereof, and methods of using such compositions for targeting delivery of the one or more active agents to a desired site. The one or more active agents preferably have a particle size of about 2 microns or less. The targeted delivery can be used, for example, for disease sensing, imaging, or drug delivery.

Disclosed is a novel therapeutic means against interferon-resistant hepatitis C. Specifically disclosed are: a pharmaceutical composition for treating interferon-resistant hepatitis C, which is characterized by comprising at least one component selected from the group consisting of an ω-3 polyunsaturated fatty acid, a pharmaceutically acceptable salt of the fatty acid and an ester of the fatty acid as an active ingredient; and a method for utilizing the pharmaceutical composition.

Provided is a method for joint-mining of coalbed gas and coal. The method comprises: a well-drilling step; a fracturing and penetration step; a coalbed gas extraction step: an ignition step, and an underground gasification step. The method combines an underground coal gasification technology and a coalbed gas extraction technology, not only allows for utilization of the high temperature of underground gasification to heat a coalbed. thus increasing the permeability of a coal seam. and increasing the recovery rate of the coalbed gas, but also allows for utilization of the coalbed gas to perform the drilling and the fracturing and penetration processes, thus increasing the efficiency of underground coal gasification for mining.

A slow cooker comprises a case; a control circuit component and an inner pot for receiving food are disposed inside the case; the inner pot is arranged inside the case in a pick-and-place manner; a temperature detection component for temperature detection is arranged on the sidewall of the inner pot, and a mount seat connected to the case is arranged at the bottom of the inner pot; a liftable heating apparatus is arranged on the mount seat; the heating apparatus comprises a heating component and a lifting mechanism which can drive the heating component upwards and downwards. A temperature detection component arranged in the slow cooker is capable of detecting the temperature in the inner pot precisely; a lifting mechanism arranged in the slow cooker is capable of adjusting the distance from the inner pot to preheat the inner pot, improving cooking efficiency.

A medical composition for reducing the rate of new-onset diabetes caused by administration of a statin or for inhibiting an increase in blood glucose level by administration of a statin, the composition containing at least one ingredient selected from the group consisting of icosapentaenoic acid and pharmaceutically acceptable salts or esters thereof as an inactive ingredient.

Compositions and methods are provided for treatment of cartilage defects in animals and humans. The compositions of the invention include synovial tissue, synovial cells and matrices containing synovial (or cambium) tissue or cells for use in filling a cartilage defect. The matrix and synovial tissue or cell preparations may also contain a proliferation agent, transforming factor or other active agents to promote healing. A controlled-release delivery system may be used to administer the transforming factor. The compositions of the invention also include a synovial covering membrane or devitalized fascial sheet for covering the cartilage defect. The methods of this invention are those in which a minimally invasive surgical intervention is performed to remove a small portion of synovial membrane from a joint. Portions of the synovial membrane, or cells expanded in vitro, are implanted alone or within a matrix, into the defect site, where they produce new cartilage tissue and repair the defect. Alternatively, partially transformed synovial-derived tissue may be formed in situ and implanted into the defect site.

There is provided a composition comprising one or more photoactive compounds and one or more optimization agents. Surprisingly, the composition requires a small amount of optimization agent to efficiently optimize the polarity, critical wavelength, SPF, PFA, Star Rating, photostability, or any combinations thereof, of the composition. Subsequently, an efficient sunscreen composition is achieved.

Particulate cartilage compositions for stimulating chondrogenesis and producing cartilage regeneration and processes for their preparation are disclosed. Methods for regenerating articular cartilage are also disclosed.

There is provided a composition comprising one or more photoactive compounds and one or more optimization agents. Surprisingly, the composition requires a small amount of optimization agent to efficiently optimize the polarity, critical wavelength, SPF, PFA, Star Rating, photostability, or any combinations thereof, of the composition. Subsequently, an efficient sunscreen composition is achieved.

Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a distribution of particle sizes within the range of from about 60 microns to about 500 microns.

An antiloading composition includes a first organic compound. The compound has a water contact angle criterion that is less than a water contact angle for zinc stearate. The first compound also satisfies at least one condition selected from the group consisting of a melting point Tmelt greater than about 40° C, a coefficient of friction F less than about 0.3, and an antiloading criterion P greater than about 0.3. Another embodiment includes a second organic compound, having a different water contact angle from that of the first organic compound. The composition has a particular water contact angle W°p that is determined, at least in part, by the independent W°g of each compound and the proportion of each compound in the composition. Also, an abrasive product includes the antiloading composition. A method of grinding a substrate is disclosed that includes employing effective amount of an antiloading composition. Further disclosed is a method of selecting an antiloading compound.

The present invention relates to cancer vaccines composed of the signal peptide domain of tumor associated antigens or proteins. The peptide vaccines of the invention are characterized by having multiple MHC class I and class II epitopes which are highly abundant in the population. Therefore, these vaccines are likely to induce a strong, comprehensive immune response against the target proteins in the majority of the vaccinated population, and thereby induce an immune reaction against tumors expressing such target proteins. Specifically, the invention relates to peptide vaccines composed of the signal peptide domain of Mucin (MUC1), BAGE-1 or ARMET, and their use for the treatment of cancers which express Mucin (MUC1), BAGE-1 or ARMET.

A novel and safe composition has been discovered that is effective for cleaning dental appliances (e.g. removable braces, retainers, dentures, etc.). This composition bleaches, disinfects, and deodorizes the appliance, while removing plaque that has accumulated on the appliance during wear. The composition comprises a chloramine bleaching agent that liberates hypochlorous acid upon contact with water, a surfactant, a water-soluble carboxylic acid and an alkaline base to produce effervescence and regulate pH, a sequestering agent for alkaline earth metal ions, a drying agent, and an indicator dye that signifies the end of the cleansing process. In a preferred method of using this invention, the premixed components are added to water, and the dental appliance is submerged in the resulting effervescent solution until a color change indicates that cleaning is complete. This invention provides a safe, effective, and convenient method for cleansing and disinfecting dental appliances.

Compositions and methods are provided for treatment of cartilage defects in animals and humans. The compositions of the invention include synovial tissue, synovial cells and matrices containing synovial (or cambium) tissue or cells for use in filling a cartilage defect. The matrix and synovial tissue or cell preparations may also contain a proliferation agent, transforming factor or other active agents to promote healing. A controlled-release delivery system may be used to administer the transforming factor. The compositions of the invention also include a synovial covering membrane or devitalized fascial sheet for covering the cartilage defect. The methods of this invention are those in which a minimally invasive surgical intervention is performed to remove a small portion of synovial membrane from a joint. Portions of the synovial membrane, or cells expanded in vitro, are implanted alone or within a matrix, into the defect site, where they produce new cartilage tissue and repair the defect. Alternatively, partially transformed synovial-derived tissue may be formed in situ and implanted into the defect site.

The present invention provides a dispensing apparatus and method for the delivery of remediation agents into waste systems wherein the apparatus is capable of generating and maintaining a controlled release of concentrated a remediation composition throughout the delivery cycle. The invention also provides a dispensing apparatus and methods wherein the remediation agent is a remediation agent that includes living organisms. Finally, the invention provides a dispensing apparatus and methods wherein compositions of remediation agents are conveniently formulated for specific applications providing a range of retention, activation and release profiles that optimize the remediation effectiveness.

Polymers which comprise polymer chains of terpolymer type which are constituted by poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) of PEO-PPO-PEO form, which are modified at their termini by groups which can essentially be other chains of PEO-PPO-PEO, acid segments, amine groups or PEOs, these chains being linked to the terpolymer chains via chemical bridges which are constituted by urethane bridges, urea bridges, allophanate bridges and biuret bridges, and which comprise more than 80% by weight of said PEO-PPO-PEO.Thermoreversible physical gels of high viscosification index, which contain these polymers, and their uses.Preparation of these polymers and of these gels.

An emollient composition comprising at least 5-30% by weight polyethylene, 0-60% by weight petrolatum, and 0-50% octyl palmitate. These emollient compositions may be used as emollient carriers for various materials, such as fragrances and pigments or dyes, to be externally applied to the skin. These emollient compositions may be formed into particulate shapes, such as spheres, for subsequent use in cosmetic products.

Embodiments of the invention provide a method, apparatus and article of manufacture for modeling a variety of three-dimensional (3D) utility networks constructed from individual network part elements. In one embodiment, users may construct a utility network by selecting and assembling a network of inter-connected parts, where each part is selected from a pipe and structure list. Connectivity among parts is established through part placement. Structure and connected pipe properties may be managed as a single property set. As parts are placed in the utility network, auto-sizing logic resizes existing structures to connected pipes. Pipes and structures are represented by part model data that defines a set of common behavior and properties. When a user modifies part model data or property sets or moves inter-connected parts, a logic component resizes and automatically updates any associated two-dimensional and three-dimensional views of the utility network.

A surface treatment process comprises (a) providing at least one optical device; (b) providing a curable surface treatment composition comprising (1) at least one fluorinated organosilane compound comprising (i) a monovalent segment selected from polyfluoroalkyl, polyfluoroether, polyfluoropolyether, and combinations thereof and (ii) a monovalent endgroup comprising at least one silyl moiety comprising at least one group selected from hydrolyzable groups, hydroxyl, and combinations thereof, and (2) at least one fluorinated organosilane compound comprising (i) a multivalent segment selected from polyfluoroalkane, polyfluoroether, polyfluoropolyether, and combinations thereof and (ii) at least two monovalent endgroups, each independently comprising at least one silyl moiety comprising at least one group selected from hydrolyzable groups, hydroxyl, and combinations thereof; (c) applying the curable surface treatment composition to the optical device; and (d) curing the applied, curable surface treatment composition.

A Phyto-nutraceutical composition for the prevention and treatment of hypertensive disorders is provided. A specific combination of extracts of plants and nutraceuticals is provided, based on categorizing plants and nutraceuticals into one of three groups, Energy, Bio-Intelligence, and Organization. Such combinations have synergistic effects, with minimal side effect.

Polymers which comprise polymer chains of terpolymer type which are constituted by poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) of PEO-PPO-PEO form, which are modified at their termini by groups which can essentially be other chains of PEO-PPO-PEO, acid segments, amine groups or PEOs, these chains being linked to the terpolymer chains via chemical bridges which are constituted by urethane bridges, urea bridges, allophanate bridges and biuret bridges, and which comprise more than 80% by weight of said PEO-PPO-PEO. Thermoreversible physical gels of high viscosification index, which contain these polymers, and their uses. Preparation of these polymers and of these gels.

Provided herein are copolymer electrolytes and electrocatalyst platforms, including brush block copolymers, triblock brush copolymers and pentablock brush copolymers. The copolymers described have beneficial chemical, physical and electrical properties including high ionic conductivity and mechanical strength. In embodiments, for example, the provided copolymer electrolytes and electrocatalyst platforms are doped with lithium salts or mixed with ionic liquids to form ion gels. In some embodiments, the copolymers provided herein self-assemble into physically cross-linked polymer networks with additional useful properties. The provided copolymers have low dispersity in the polymer side chains and do not require post-polymerization modifications.

The present invention relates generally to the field of generating fusion proteins to be used in cancer therapy, and more specifically, to nucleotide sequences encoding the fusion proteins, wherein the chimeric fusion proteins comprises at least one targeting moiety and at least one immunomodulatory moiety that counteracts the immune tolerance of cancer cells.

The invention relates to a process for converting an elastomer from scrap to a regenerated elastomer which comprises the steps of: (a) introducing the elastomer from scrap into a vessel; (b) agitating the elastomer from scrap; (c) heating the elastomer from scrap to a temperature below a temperature where the elastomer begins to degrade; (d) introducing an oil into the vessel and admixing together the elastomer from scrap and the oil; and (e) cooling down the so formed regenerated elastomer, whereby the regenerated elastomer has properties similar to a corresponding virgin elastomer. Steps (b) and (c) are carried out simultaneously or separatelty and steps (c) and (d) are carried out simultaneously or separately. A regenerated elastomer and its use are also disclosed.

Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and / or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect.

The present invention provides a granular pesticide composition which is highly effective in controlling pests. In particular, the pesticide composition of the present invention is prepared by adsorbing an oil in water emulsion on inert granular particles. These compositions provide improved release of the pesticide. Methods of preparing the granular pesticide composition and methods of use thereof are disclosed.

The subject invention provides novel and highly effective methods and devices for convenient and effective wound irrigation.