185 results about "Orthoester" patented technology

The present invention relates to fragrance delivery systems which comprise: A) from about 0.01% by weight of a pro-fragrance component which comprises pro-fragrances or pro-accords selected from at least two of the following: i) aldehyde and ketone releasing pro-fragrances, preferably an oxazolidine pro-fragrance; ii) β-amino pro-fragrances; and iii) orthoester pro-accords; and B) the balance carries and others adjunct ingredients.

The present invention relates to methods and compositions for treating subterranean formations, and more specifically, to improved methods and compositions for generating acids for use downhole, for example, to at least partially degrade the acid-soluble portions of filter cakes deposited in subterranean formations. In one embodiment, the present invention provides a method of degrading an acid-soluble portion of a filter cake comprising contacting the acid-soluble portion of the filter cake with an acid generated from an orthoester.

Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with orthoester-type protecting groups. The 2′ protected monomers also include a second, aryl carbonate-type, protecting group. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.

A hybrid contact lens includes a substantially rigid center portion and a substantially flexible skirt portion connected to the center portion. The skirt portion is formed using xerogels compatible with diluents comprising at least one selected from polylactic acid, polyglycolic acid, lactide, glycolide, a polyacetal, a cyclic acetal, a polyketal, a cyclic ketal, a polyorthoester, a cyclic orthoester, di-t-butyl-dicarbonate, tris(trimethylsilyl)amine, and 2,2,2-trifluoroacetamide. These diluents are formulated to function as a stand-in for water in the xerogel polymer, allowing the xerogel to form and bond to the rigid center portion in its fully expanded state. Upon hydration of the hybrid lens, substantially little dimensional change, and thus substantially little distortion, is obtained in the skirt portion. The diluents of the present invention further preserve the mechanical integrity of the xerogel, allowing the xerogel to be machined to final shape, improving the dimensional tolerances which can be achieved in the hybrid lens.

The invention relates to particular orthoester based polymers as well as the use of specific orthoester based polymers as a demulsifier for water / oil emulsions. Products suitable for use according to the invention have the formula (I), wherein R1 is hydrogen or a hydrocarbyl group with 1-4 carbon atoms, R2, R3, and R4 are, independently, a group comprising C3-C4 alkyleneoxy groups and / or ethyleneoxy groups in any order, and an end group Y, which is, independently, hydrogen, a hydrocarbyl group with 1-30 carbon atoms, a group —(CH2)zNR5R6 or —(CH2)zN+R5R6R7, wherein each of R5, R6, and R7 is, independently, an alkyl group with 1-22 carbon atoms or —CH2CH2OH, and z is 2 or 3, provided that at least one of the groups R2, R3, and R4 comprises at least one block of at least on then average 4 alkyleneoxy groups with 3 and / or 4 carbon atoms, and provided that if Y is hydrogen, then at least one of n and m is a number of 1-100, or a di- or polycondensate of the polymer via free hydroxyl groups in R2, R3 or R4.

In one embodiment, the present invention provides a method of reducing the viscosity of a viscosified treatment fluid comprising contacting the viscosified treatment fluid with an acid generated from an orthoester composition that comprises an orthoester. In another embodiment, the present invention provides a method of reducing the pH of a viscosified treatment fluid comprising providing an orthoester composition that comprises an orthoester; contacting the viscosified treatment fluid with the orthoester composition; allowing the orthoester to generate a generated acid; and allowing the generated acid to at least partially reduce the pH of the viscosified treatment fluid. Embodiments of fracturing and gravel packing methods also are disclosed.

Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and / or microemulsions of the invention, are also provided.

The invention relates to a catalytic composition comprising: a first component which is at least a component with one or more metals from groups 3A, 4A, 5A, 6A, 7A, 8, 1B, 2B, 3B, 4B; and a second component selected from (1) at least one ionic liquid which consists of a compound formed by cations and anions and which is a liquid at ambient temperature, (ii) a matrix to which the first component is bound or on which it is supported, and (iii) a combination of the two. The invention relates to the use of said catalytic composition in a method for the insertion of carbon dioxide into an organic compound and, preferably, a compound selected from epoxides, acetals and orthoesters. The invention also relates to catalytic compositions comprising said metallic compounds.

A method is provided for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid or ester thereof. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid. In addition, the invention provides water-soluble polymers bearing a terminal carboxylic acid or ester thereof, intermediates and reagents useful in carrying out the method, as well as gels, pharmaceutical formulations, conjugates related to the described water-soluble polymer derivatives.

A polymer coating for implantable medical devices based on polyorthoesters and methods for fabricating the coating are disclosed. The implantable medical devices made of polyorthoesters and methods for fabricating thereof are also disclosed.

The phenoxyphosphazene compound of the present invention is prepared by treating a phenoxyphosphazene compound with (a) at least one adsorbent selected from activated carbon, silica gel, activated alumina, activated clay, synthetic zeolite and macromolecular adsorbents, (b) at least one reagent selected from metal hydrides, hydrazine, hypochlorites, thiosulfates, dialkyl sulfuric acids, ortho esters, diazoalkanes, lactones, alkanesultones, epoxy compounds and hydrogen peroxide or (c) both the adsorbent and reagent. Incorporation of the phenoxyphosphazene compound prepared by the process of the invention into a synthetic resin achives the following advantages: the synthetic resin can be prevented from discoloration; when the resultant resin composition is stored for a long time, the properties of the synthetic resin, such as heat resistance, weatherability, resistance to discoloration and chemical resistance are not deteriorated; and the resin composition gives a resin composition molded article excellent in properties such as flame retardancy, thermal stability, and moldability.

A hybrid contact lens includes a substantially rigid center portion and a substantially flexible skirt portion connected to the center portion. The skirt portion is formed using xerogels compatible with diluents comprising at least one selected from polylactic acid, polyglycolic acid, lactide, glycolide, a polyacetal, a cyclic acetal, a polyketal, a cyclic ketal, a polyorthoester, a cyclic orthoester, di-t-butyl-dicarbonate, tris(trimethylsilyl)amine, and 2,2,2-trifluoroacetamide. These diluents are formulated to function as a stand-in for water in the xerogel polymer, allowing the xerogel to form and bond to the rigid center portion in its fully expanded state. Upon hydration of the hybrid lens, substantially little dimensional change, and thus substantially little distortion, is obtained in the skirt portion. The diluents of the present invention further preserve the mechanical integrity of the xerogel, allowing the xerogel to be machined to final shape, improving the dimensional tolerances which can be achieved in the hybrid lens.

The invention relates to a heavy metal sewage treatment agent which is prepared from dodecyl diethylene triamine, dimethyl diallyl ammonium chloride, acrylamide, dibenzoyl peroxide, powdered activated carbon, ethylene diamine tetraacetic acid, tert-butylamine, carbamate, dithiocar-bamate, thiocarbamic acid ester, starch, cellulose, water soluble starch xanthate ester, sodium silicate, potassium peroxodisulfate, sodium hydrosulfite, strong base and water. The heavy metal sewage treatment agent disclosed by the invention is formed by being modified with a high-molecular compound; the mixture contains a plurality of active groups which can be complexed, chelated, absorbed and exchanged with heavy metal, so that heavy metal ions in the aqueous solution can be removed; the heavy metal sewage treatment agent has good removal effect on heavy metal ions, the removal rate is above 97%, and furthermore, the heavy metal sewage treatment agent has stronger Ca2+ and Mg2+ resistant capability; the removal rate of cadmium-containing sewage is 99.8%, which meets the national emission standard; and the removal rate of chromium-containing sewage is above 99.6%.

In an embodiment, a method is provided including the steps of: (A) introducing a well fluid comprising an electron-poor orthoester into a well; and (B) allowing or causing the electron-poor orthoester to hydrolyze to produce an acid and an alcohol in the well. In another embodiment, a water-based well fluid is provided, the well fluid including: (A) a continuous aqueous phase having a pH of a least 6; (B) an electron-poor orthoester; and (C) a viscosity-increasing agent.

The invention provides a fluid for use in a subterranean formation penetrated by a wellbore, the fluid comprising: (a) water; (b) an orthoester; and (c) a surfactant comprising a tertiary alkyl amine ethoxylate generally represented by the following formula: wherein R is an alkyl group or aryl group, and wherein X and Y are each independently at least one. The invention also provides a method of fracturing a subterranean formation, comprising the step of forming a foamed fracturing fluid comprising water; an orthoester; a surfactant comprising a tertiary alkyl amine ethoxylate generally represented by the formula above; and a gas. The method also provides the step of introducing the foamed fracturing fluid into a subterranean formation at a pressure sufficient to create a fracture in the subterranean formation.

Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with orthoester-type protecting groups. The 2′ protected monomers also include a second, aryl carbonate-type, protecting group. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.

The invention relates to a coating composition wherein orthoester groups block the hydroxyl groups of the poly(meth)acrylate wherein the orthoester groups can be removed through hydrolysis in order to facilitate cross-linking through reaction with isocyanate compounds. The invention also relates to a process for curing the aforementioned coating composition. The invention also relates to a process for coating substrates wherein a clear coat comprising the aforementioned coating composition is coated over a base coat. The invention also relates to a process for blocking the hydroxyl groups of a poly(meth)acrylate compound through reaction with an orthoester compound.

Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.

The invention provides a method for synthesizing difluprednate from a sterol fermentation product. The sterol fermentation product, namely 9 Alpha-hydroxyl-androstane-1,4-diene-3,17-diketone (9 Alpha-OH-AD) obtained by fermenting phytosterol of which the content in byproducts of the grease industry is very high, serves as a starting raw material. The method comprises the following 15 reaction steps in total: dehydrating steride 9-hydroxyl to form a double-bond; adding 17-carbonyl with acetylene; dehydrating; producing 21-copper carbonyl under an acid condition; epoxidizing 16,17-double bond; oxidizing periodide and introducing 21-hydroxyl; performing ring opening on 16,17 Alpha-epoxy hydrobromate; hydrogenating for removing 16 Beta bromine; forming a ring on orthoester; performing ring opening; esterifying; epoxidizing 9,11-double bond-Beta; enolizing and esterifying; performing ring opening on 6-electrophilic fluoro; and performing ring opening on 9,11-epoxy fluoro. According to the method, steride 17 Alpha and 21-dyhydroxyl are efficiently built by means of periodide oxidization, epoxide ring-opening and debromination and an important intermediate type 11 compound is obtained; in the whole process, a large quantity of heavy metal pollutant chromium which is generated when producing corticoid medicines in the traditional industry is effectively avoided, so that the method is green, environment-friendly and suitable to industrialized production.

The invention relates to a synthesis method of diamido ortho-ester monomer, which belongs to the technical field of organic chemistry and biomaterials. The diamido ortho-ester monomer is 4-aminomethyl-2-amino pentyloxy-2-R group-[1,3] dioxane as shown in formula I, wherein the R group is hydrogen or methyl, and the diamido ortho-ester monomer is a new generation of ortho-ester monomer in a brand-new structure. The synthesis method of the diamido ortho-ester monomer comprises the following steps that: 3-amino-1,2-propanediol is taken as the raw material, reacts with trimethyl ortho ester under the action of an acid catalyst after reacting with ethyl trifluoroacetate to protect the amino, the obtained product exchanges and reacts with 5-trifluoroacetyl amino pentanol ester under the action of the catalyst to obtain a monomer precursor, and finally the precursor is added into lye to remove a trifluoroacetyl protecting group so as to obtain the diamido ortho-ester monomer. The synthesis method has the advantages of easily available raw materials, simple synthesis process and higher economy and yield and is applicable to large-scale industrial production; and simultaneously, the monomer is extremely stable at normal temperature, and can be used for the research and development of a new generation of poly ortho ester polymer biomaterials.

The invention pertains to a coating composition comprising a) a first compound comprising at least one bicyclo-orthoester group, p0 b) a second compound comprising at least two isocyanate groups, and c) a third compound comprising at least one thiol group. The invention also relates to a process for curing the present coating composition. More particularly, the latent hydroxyl groups of the bicyclo-orthoester groups have to be deblocked and reacted with the isocyanate-groups of the second compound if the present coating composition is to be cured.

The present invention relates to binder compositions containing sulphonate-functional polyisocyanates and one or more polyorthoester and / or bicyclo orthoester groups which are either chemically incorporated into the sulphonate-functional polyisocyanates or present in admixture with the sulphonate-functional polyisocyanates. The present invention also relates to a process for preparing these binder compositions from either OH functional polyorthoesters or from bicyclo orthoesters, and to coating, adhesive and sealant compositions containing the binder compositions of the invention.