392 results about "Oxazolidine" patented technology

The present invention relates to novel heterocyclic pro-fragrances, preferably oxazolidines, tertahydro-1,3-oxazines, thiazolidines, or tetrahydro-1,3-thiazines, more preferably oxazolidines, or tertahydro-1,3-oxazines, most preferably oxazolidines, which are capable of sustained release of fragrance raw material ketones and aldehydes and to fragrance delivery systems which comprise said pro-fragrances.

An antibacterial 3,5-substituted oxazolidione derivative and its salt with strong activity to resist gram-position bacteria, their preparing process, their application in preparing antibacterial agents and the antibacterial medicine containing them as active components are disclosed.

The present invention is directed to a new process of preparing highly pure Florfenicol. The invention is further directed to new oxazolidine derivatives useful in making Florfenicol and processes of making these derivatives. Examples of such intermediates include (4R,5R)-3-acetyl-2,2-dimethyl-4-hydroxymethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine; and (4S,5R)-3-acetyl-2,2-dimethyl-4-fluoromethyl-5-[4-(methylsulfonyl)phenyl]-1,3-oxazolidine.

The invention relates to a ginger shampoo capable of protecting hairs and preventing losing hairs, wherein the ingredient of the shampoo comprises A group, B group and C group; A group: 38.24% of deionized water, 0.05% of EDTA (Ethylene Diamine Tetraacetic Acid) 4 sodium, 0.2% of hydroxypropyl three methyl ammonium chloride hydroxypropyl guar gum, 0.2% of hydroxypropyl guar gum, 53% of sodium lauryl ether sulfate, 2% of coconut oil amide diethanol amine and 1% of glycerol distearate; B group: 0.15% of anhydrous citric acid, 231.34% of simethicone, 0.2% of (propanediol and water) chamomile extraction, 0.3% of poly methoxy-double oxazolidine, 0.40% of essence and 5% of ginger juice; and C group: 0.73% of potassium chloride and 2.19% of deionized water. The shampoo comprising the ginger has the effects for cleaning scalp, removing scurf, preventing and cure alopecia, etc; and the shampoo can promote blood circulation of the head and strengthen hair roots.

The present invention relates to a composition comprising: (i) an anti-microbial agent comprising a polymeric biguanide, alone or in combination with at least one other microbiologically active component selected from the group consisting of quaternary ammonium compounds, monoquaternary heterocyclic amine salts, urea derivatives, amino compounds, imidazole derivatives, nitrile compounds, tin compounds or complexes, isothiazolin-3-ones, thiazole derivatives, nitro compounds, iodine compounds, aldehyde release agents, thiones, triazine derivatives, oxazolidine and derivatives thereof, furan and derivatives thereof, carboxylic acids and the salts and esters thereof, phenol and derivatives thereof, sulphone derivatives, imides, thioamides, 2-mercapto-pyridine-N-oxide, azole fungicides, strobilurins, amides, carbamates, pyridine derivatives, compounds with active halogen groups, and organometallic compounds; and (ii) an amphoteric co-polymer of the Formula (1): wherein:[A] is of Formula (9), [B] is of Formula (10), [C] is of Formula (12), [D] is of Formula (13), and X is of Formula (11), wherein [A], [B], [C] and [D] may occur in any order; T is an optionally substituted substituent; L, G and Z each independently is an optionally substituted linking group; R1, R2 and R3 are each independently H, optionally substituted C1-20-alkyl or optionally substituted C3-20-cycloalkyl; R4 and R5 are each independently H or C1-4-alkyl; q is 15 to 1000; p is 3 to 50; J is an optionally substituted hydrocarbyl group; F is an acidic substituent; E is a basic substituent; m is 0 to 350; n is 1 to 75; v is 0 to 100; y is 1 to 100; b is 0, 1 or 2; s is 0 or 1; w is 1 to 4; and provided that at least one of R4 and R5 is H.

The invention relates to a method for preparing an oxazolidinone compound and an intermediate thereof. Specifically, two fragments are coupled to prepare the oxazolidinone compound by virtue of Suzuki reaction. The method is simple in process, short in reaction time and high in yield and is suitable for industrial production. Furthermore, the method for preparing the intermediate of the oxazolidinone compound has the advantages of simplicity in operation, high yield and low cost.

The invention provides a preparation method of reaction type Mannich polyether polyol with permanent flame retardant effect. The preparation method of reaction type Mannich polyether polyol with permanent flame retardant effect comprises the following steps: reacting paraformaldehyde or formaldehyde solution with diethanol amine to obtain 3-ethoxyl-1,3-oxazolidine reaction liquid, and then carrying out reduced pressure distillation to obtain the product 3-ethoxyl-1,3-oxazolidine; reacting aromatic phenol compounds or / and melamine compounds with 3-ethoxyl-1,3-oxazolidine to obtain Mannich base as intermediate; and carrying out polymerization reaction between the intermediate Mannich base and epoxy compound to obtain crude product of reaction type Mannich polyether polyol with permanent flame retardant effect, then carrying out reduced pressure distillation to remove impurities with low boiling points, and thus obtaining finished product. The reaction type Mannich polyether polyol simultaneously has the high stability and thermal stability of rigid polyurethane foam and the flame resistance of phenolic foam, is applied to foaming rigid polyurethane foam, and has wide application prospect.

The present invention relates to formulations of asphaltenes' inhibitor-dispersant additives based on oxazolidine derived from polyalkyl or polyalkenyl N-hydroxyalkyl succinimides. Said formulations can contain inert organic solvents, preferably including: toluene, mixtures of xylene, o-xylene, p-xylene, kerosene, turbo-fuel; or inert hydrocarbon solvents having boiling points within the range of gasoline and diesel; or inert hydrocarbon or organic solvents having a boiling point within a range from 75 to 300° C. The ratio in weight of inert organic solvents to additive that prevents and controls the precipitation and deposition of asphaltenes ranges from 1:9 to 9:1, preferably from 1:3 to 3:1.

The present invention relates to stable microbicidal compositions which are characterized in that they comprise derivatives of methylenebisoxazolidine and 1H-benzimidazol-2-ylcarbamic acid. The compositions according to the invention can be employed in industrial products. The derivatives of methylenebisoxazolidine are used, in particular, for increasing the solubility of derivatives of 1H-benzimidazol-2-ylcarbamic acid in liquid preparations.

The invention discloses a preparation method of an intermediate 3-[(2R,5S)-5-(4-fluorophenyl)-2-[(S)-(4-fluorophenylamino)(4-R-oxophenyl)methyl]-5-hydroxyvaleryl]-(4S)-phenyl-2-oxazolidinone (represented by general formula I) for synthesizing ezetimibe. The method is characterized in that the intermediate is prepared by using (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxyvaleryl]-4-phenyl-1,3-oxazolidin-2-one and 4-R-oxophenylmethylene-4-fluoroaniline as initial raw materials. The method has the advantages of no need of an expensive reagent, simple operation, high product yield, high product purity and the like, and is suitable for industrialized production.

The invention discloses a method for preparing hapten, antigen and antibody of 5-methylmorpholine-3-amino-2-oxazolidone derivatives. The hapten obtained by designing and preparing the 5-methylmorpholine-3-amino-2-oxazolidone derivatives is similar to counterparts of the 5-methylmorpholine-3-amino-2-oxazolidone derivatives in molecular structure, spatial chemistry and electron distribution. The linking arm in the hapten structure is not easy to induce and generate 'arm antibody', and the organism is easier to identify as a saturate carbon chain of a certain length is used; the antigen which is prepared by hapten cross coupling carrier protein ensures the organism to produce the antibody of high tilter and good specificity in accordance with the 5-methylmorpholine-3-amino-2-oxazolidone derivatives; and the antibody is used for detecting the residue of 5-methylmorpholine-3-amino-2-oxazolidone in animal source food with quick response and stable result.

The invention discloses a blood sample collecting device. The collecting device comprises a collecting tube, wherein an orifice of the collecting tube is provided with a sealing rubber plug, the outside of the rubber plug is provided with a protective cap, the collecting tube is filled with additives, the additives are composed of a blood anticoagulation, a hemocyte nucleic acid stabilizing agent, a blood plasma nucleic acid stabilizing agent, and a pH buffer solution; the blood anticoagulation is one or more of oxalate, heparinate and citrate, the pH buffer solution is one of glycine-sodium hydroxide-hydrochloric acid buffer solution; the hemocyte nucleic acid stabilizing agent is one or more of allantoin, 5,5-dimethyl hydantoin and oxazolidine; the blood plasma nucleic acid stabilizing agent is N-acetic acid azomethine, N-(3-acetic acid-amylamine)azomethine. The blood sample collecting device simultaneously contains the hemocyte nucleic acid stabilizing agent and the blood plasma nucleic acid stabilizing agent, and does not contain free aldehyde material, so that the blood sample can be stored in long term at normal temperature, and the free nucleic acid level of the blood sample can be stabilized, and the completeness of the free nucleic acid can be maintained.

The invention discloses a preparation method for tedizolid as shown in a formula IV. According to the method, tedizolid is prepared through chemical combination of a compound as shown in a formula I and a compound as shown in a formula II via a coupling reaction; and tedizolid phosphate with medical purposes can be prepared by subjecting the obtained tedizolid to esterification by phosphate. The preparation method has the advantages of milder reaction conditions, a few produced impurities and simple post-treatment. According to the invention, the reaction mechanism of Suzuki-Miyaura coupling is employed to connect boric acid as shown in the formula I and derivatives thereof with the compound as shown in the formula II, so reaction selectivity is high, a few impurities are produced, and a synthetic ratio is more than 90%; and oxazolidinone borate is used to react with tetrazole, so conditions are milder, and the generation rate of impurities is lower.

The invention relates to a medicine producing field, specifically, to an improved producing method of antibacterial medicine nifuratel. The method makes use of thiourea as initial material to produce nifuratel. The improvement is that it is no longer to use methyl mercaptan or methomyl in the known method while producing the intermediate 2-(methylthiomethyl)hydropropane. Furthermore, the invention is no longer to use metal natrium in the known method when the 3-methylthio-2-hydroxy-propylhydrazine and diethyl carbonate are heated to produce N-amido-5-methylthiomethyl-2-oxazolidone in the existance of alkali. All of the improvements largely improve the preparation of the nifuratel, especially for the production condition in a large scale, reduce the environment pollution and benefit to ensure the production safety.

The invention provides a production method of a polyoxazolidone laminated board, comprising the following steps: reacting diisocyanate with epoxide resin by taking imidazole compounds as catalyst for producing polyoxazolidon resin during the gradual rise of temperature; and then producing the polyoxazolidone laminated board by using the polyoxazolidon resin. The polyoxazolidone laminated board the end of which is sealed with isocyanate has better mechanical strength, favorable heat resistance and high glass transition temperature above 155 DEG C; and when in use at 180 DEG C or 200 DEG C, the mechanical property and electrical propertye of the polyoxazolidone laminated board are over 70 percent.

The invention relates to a synthetic method of cabazitaxel, which comprises the following steps: taking a compound 10-deacetylbaccatin III as a starting raw material and reacting with a protective agent to carry out selective protection on 7 and 10 hydroxyls; then carrying out selective protection on 13 hydroxyls of the compound, removing 7 and 10 protection radicals and carrying out methylation reaction; removing 13 protection radicals and carrying out condensation reaction with an oxazolidine carboxylic acid side chain; and removing and protecting a condensation product to obtain the cabazitaxel. The synthetic method has the beneficial effects that the proper protection radicals and a removal and protection method are selected, the oxazolidine carboxylic acid side chain is finally connected, and the synthetic method has the characteristics of low production cost, high yield, mild reaction conditions and simplicity in operation and is particularly suitable for industrial production.

Silicic acid esters to which fragrances are bound, preferably as 1-aza-3,7-dioxabicyclo[3,3,0]octane compounds or as monocyclic oxazolidines and that are suitable for adding fragrance to detergents and cleaning agents because they release the bound fragrances in hydrolysis.

A process for the preparation of taxanes comprising wherein R is a tert. butoxycarbonyl or benzoyl group; PMP is p-methoxyphenyl group; G1 is acetyl group; G2 is haloacetyl group comprisinga) protecting the C-7 hydroxyl group of 10-deacetylbaccatin III with haloacetyl chlorides and then acetylating the C-10 hydroxyl group with acetyl chloride to obtain a protected 10-deacetylbaccatin III (1);b) subjecting the protected 10-deacetylbaccatin III (1) to coupling with an oxazolidine-5-caboxylic acid of formula 2 wherein R is tert. butoxycarbonyl or benzoyl; PMP is p-methoxyphenyl group in the presence of a condensation agent and an activating agent to obtain C-13 esters of formula 3;c) treating the coupled products 3 with weak acidic medium to open the oxazolidine ring to obtain intermediates of formula 4; wherein R is a tert. butoxycarbonyl or benzoyl group; G1 is acetyl group; G2 is haloacetyl groupd) subjecting the intermediates of compound 4 to selective deprotection of haloacyl group in the presence of acetyl group under mild alkaline condition at −20 to +40° C. for 6-24 h in the presence of ammonia or aliphatic amine or aromatic amines or their combination to obtain paclitaxel or docetaxel.

The invention provides a preparation method of diethyl N,N-bis(2- hydroxyethyl) aminomethylphosphonate, comprising the following steps: (1) carrying out depolymerization on paraformaldehyde; (2) carrying out ring formation on formaldehyde and diethanol amine to prepare 3-(2- hydroxyethyl)-1,3-oxazolidine; (3) reacting 3-(2- hydroxyethyl)-1,3-oxazolidine with diethyl phosphite in the presence of anhydrous Lewis acid catalysts; and (4) filtering and recovering the catalysts to obtain a yellow transparent liquid product. The overall yield of the whole process reaches more than 99 %, and the content of diethyl N,N-bis(2- hydroxyethyl) aminomethylphosphonate in the product is 94 %-96 %. The preparation method disclosed in the invention is simple and efficient, has the advantages of high product yield, high content of effective components in the product, reduction of temperature in dehydration process, shortening of time, and low energy consumption, reduces the water content of the final product to 0.1-0.2 %, and reduces the dosage of the catalysts by 20-50%. The preparation method is suitable for large-scale industrial production.

Aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are sodium channel blockers; pharmaceutical compositions that include an effective amount of the aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds and a pharmaceutically acceptable carrier, and a method of treatment of acute pain, chronic pain, visceral pain, inflammatory pain, or neuropathic pain, as well as initable bowel syndrome, Cnohns disease, epilepsy, partial and generalized tonic seizures, multiple sclerosis, bipolar depression, and tachy-arrhythmias by the administration of an effective amount of aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are described.

An improved method of preparing oxazolidine protected aminodiol compounds is disclosed. These compounds are useful intermediates in processes for making Florfenicol.

The leather tanning agent having no chrome or having little chrome is made up by using amine material containing carboxymethyl group and aliphatic aldehyde compound through the processes of N-carboxymethylation reaction and ring-closing reaction. In addition to oxazolidine naphthenicbase its molecular structure also contains several functional groups of aldehyde group, carboxyl group, hydroxyl group and quaternary amino-group. Said main tanning agent can be combined with vegetable tannin extract, also can be combined with chrome for tanning leather, and can raise wet and thermal stabilizing of the finished leather and reduce dose of chrome by 30-40%.

The invention belongs to the field of drug synthesis and provides a novel method for synthetizing nifuratel. The synthesis method of the nifuratel disclosed by the invention innovatively adopts a post-treatment method of 'ethanol with water' to obtain a midbody 3-methyl mercapto-2-hydroxy propyl hydrazine (A1); high-vacuum reduced pressure distillation of the midbody 3-methyl mercapto-2-hydroxy propyl hydrazine (A1) is avoided; the nifuratel is prepared by a 'one-pot' method; preparation of a midbody N-amino-5-methylthiomethyl-2-oxazolidinone (A2) and post-treatment operation of 5-nitro-furfural (B1) are simplified; the purity of the obtained nifuratel product is higher than 99.8%; and the yield is higher than 30%. The synthesis method of nifuratel disclosed by the invention is simple, convenient and easy to control; the post-treatment operation is simple and feasible; industrialized production is facilitated; the used material is available in China; the pollution on the environment is small; and the material is cheap and easily available.

The invention discloses novel oxazolidine, a preparation method, application, and mono-component polyurethane waterproof paint. The novel oxazolidine is named as 4-mehtyl-3-(2-phenylcarbinol)-1,3-oxazolidine. The novel oxazolidine is used as a latent curing agent of the mono-component polyurethane waterproof paint. During the production process of the waterproof paint, the novel oxazolidine is added into the raw materials, one naked hydroxy group of the novel oxazolidine will react with the polyurethane prepolymer formed by the raw materials, thus the novel oxazolidine is grafted to the polyurethane prepolymer, and the novel oxazolidine (latent curing agent) can be more evenly dispersed in the waterproof paint. If the waterproof paint is stored for a long time, the grafted novel oxazolidine will be dissolved out continuously, the stability of the waterproof paint is improved, the latent curing effect is improved, and avoided is the phenomenon that the latent curing agent is precipitated from the mono-component polyurethane waterproof paint or the latent curing agent aggregates in the waterproof paint. After the waterproof paint is used, the quality of the film formed by the waterproof paint is improved.

A resin composition comprising oligomers having a molar ratio of isocyanurate to oxazolidinone greater than 1 :1, wherein the weight average molecular weight of the oligomers is less than or equal to 3000, as measured by gel permeation chromatography. Such resin compositions may be combined with a hardener to form a curable composition. Also disclosed is a process for forming a resin composition, including: reacting diisocyanates to form isocyanurates; reacting isocyanate groups in the isocyanurates and unreacted diisocyanates with an epoxy precursor to form a resin composition comprising oligomers having: a molar ratio of isocyanurate to oxazolidinone greater than 1 :1; wherein the weight average molecular weight of the oligomers is less than or equal to 3000, as measured by gel permeation chromatography. Such compositions may be useful in prepregs and laminates.

The invention discloses a new method for synthesizing rivaroxaban intermediate 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholine-3-ketone. The method comprises the following steps: reacting a compound 1 and a compound 2 in an inert solvent in the presence of lithium to get a compound 3; and carrying out an ester group removing reaction under the effect of hydrochloric acid or hydrogen chloride to get a compound 4, that is, 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholine-3-ketone. The new method provided by the invention has advantages of mild reaction condition, simple operation, easy purification and low production cost, and is environmentally friendly and suitable for industrial production.

A process for synthesizing annular carbonate or oxazolidione compound features that reaction of epoxy propane compounds or ternary acacyclic compounds on CO2 under the co-catalysis of phenol compound, schiff base and organic alkali to generate said product which can be used to prepare amidocarbonate and its unsaturated derivatives. Its advantages are cyclnc use of catalyst, high efficiency, and no poison and pollution.

3-(alk-2-ynyloxy)carbonyl-5-oxazolidine carboxylic acid and its analogs having a formulaand wherein R1 is hydrogen, aryl, heteroaryl, alkyl, alkenyl, alkynyl, R2 and R3 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, R4 is hydrogen, alkyl, alkenyl, alkynyl, aryl, substituted aryl, heteroaryl, R5 and R6 independently selected from hydrogen, alkyl, alkenyl,alkynyl, arly, heteroaryl, alkoxy, alkeyloxy, alkynyloxy, aryloxy, heteroaryloxy.