42results about How to "Good value for industrial production" patented technology

The invention discloses a compound amlodipine and valsartan solid preparation and a preparation method thereof. The preparation can be a tablet or a capsule and contains 2.5-10g of amlodipine or pharmaceutically acceptable salt thereof (calculated according to the amlodipine) and 40-640g of valsartan or pharmaceutically acceptable salt thereof (calculated according to the valsartan). The preparation method of the compound amlodipine and valsartan solid preparation comprises the steps of mixing the two medicines and the corresponding medicinal auxiliary materials according to the proportion, mixing with the corresponding lubricant or glidant after granulating in a wet method, and pressing into a tablet or filling into a capsule so as to obtain the compound amlodipine and valsartan solid preparation. In the invention, the tablet or the capsule is prepared after the two active substances with unequal doses are granulated in the wet method, and the method is simple and convenient, is easy to control the quality and is suitable for the industrialized production. More than 85% of the amlodipine in the preparation is dissolved out within 30 minutes, and the invention has favorable market popularization prospect.

The invention relates to a method for synthesizing a broad spectrum antibiotic of chloramphenicol. The method comprises the following steps of: synthesizing (R)-2-nitro-1-(4-chlorophenyl)ethanol by using p-chlorobenzaldehyde and nitromethane as raw materials in the presence of a chiral catalyst; reacting with formaldehyde to obtain (1R,2R)-2-nitro-1-(4-chlorophenyl)-1,3-propanediol, and performing catalytic hydrogenation to obtain (1R,2R)-2-amino-1-(4-chlorophenyl)-1,3-propanediol; and performing nitro substitution and dichloro acetylization on the intermediate to obtain the chloramphenicol. By the method, the common chiral resolution and aluminum isopropoxide reduction in the industry at present can be avoided, three wastes are reduced, the raw materials and reagents are cheap and readily available, the method comprises a few synthesizing steps, the yield is high, and the method is more suitable for industrial production.

The invention relates to a preparation method of (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide (I). The preparation method is characterized in that cyanoacetic acid (I) is dehydrated and condensed to obtain cyan acetic anhydride (III), the cyan acetic anhydride (III) reacts with trifluoromethyl phenyl under the action of catalyst to obtain 2-cyano-N-(4-trifluoromethyl-phenyl)-ethanamide (IV), and the 2-cyano-N-(4-trifluoromethyl-phenyl)-ethanamide (IV) reacts with the acetylchloride in the presence of sodium hydride to obtain teriflunomide (I).

The invention relates to a method for preparing a broad spectrum antibiotic of chloramphenicol. The method comprises the following steps of: synthesizing (R)-2-nitro-1-benzylcarbinol by using benzaldehyde and nitromethane as raw materials in the presence of a chiral catalyst; reacting with formaldehyde to obtain (1R,2R)-2-nitro-1-benzyl-1,3-propanediol, and performing hydrogenation reduction to obtain (1R,2R)-2-amino-1-benzyl-1,3-propanediol; and performing nitration and dichloro acetylization on the intermediate at low temperature to obtain the chloramphenicol. By the method, the common chiral resolution and aluminum isopropoxide reduction in the industry at present can be avoided, three wastes are reduced, the raw materials and reagents are cheap and readily available, the method comprises a few synthesizing steps, the yield is high, and the method is more suitable for industrial production.

The invention relates to a method for preparing a broad spectrum antibiotic of chloramphenicol. The method comprises the following steps of: synthesizing (1R,2R)-2-nitro-1-(4-chlorophenyl)-1,3-propanediol by using 4-chlorobenzaldehyde and 2-nitroethylalcohol as raw materials in the presence of a chiral catalyst, and performing catalytic hydrogenation to obtain (1R,2R)-2-amino-1-(4-chlorophenyl)-1,3-propanediol; and performing nitro substitution and dichloro acetylization on the intermediate to obtain the chloramphenicol. By the method, the common chiral resolution and aluminum isopropoxide reduction in the industry at present can be avoided, three wastes are reduced, the raw materials and reagents are cheap and readily available, p-chlorobenzaldehyde is selected as a raw material, the method comprises a few synthesizing steps, the yield is high, and the method is suitable for industrial production.

The invention relates to a method for synthesizing broad-spectrum antibiotic chloramphenicol. In the method, benzaldehyde and 2-nitroethanol are used as raw materials and are synthesized in the presence of a chiral catalyst to obtain (1R, 2R)-2-nitro-1-phenyl-1,3-propylene glycol; the (1R, 2R)-2-nitro-1-phenyl-1,3-propylene glycol is subjected to hydrogenation reduction to obtain (1R, 2R)-2-amino-1-phenyl-1,3-propylene glycol; and the (1R, 2R)-2-amino-1-phenyl-1,3-propylene glycol is dichloroacetylated and nitrified to obtain the chloramphenicol. By using the method provided by the invention, chiral separation and aluminum isopropoxide reduction which are generally used in industry at present can be avoided; three wastes (waste water, waste gas and industrial residues) are reduced; and the method has the advantages of low-cost and readily available raw materials and reagents, less synthesis steps and high yield and is more suitable for industrial production.

The invention provides a production method of creamy fermented bean curd, comprising: mixing well soybean flour and water to obtain fermentation material; adding pectinase and cellulase to the fermentation material, enzymatically hydrolyzing at 40-55 DEG C for 2-4 h, and sterilizing to obtain primary hydrolysate; adding Bacillus subtilis and Micrococcus luteus to the primary hydrolysate, enzymatically hydrolyzing at 35-45 DEG C for 8-18 h, and sterilizing to obtain secondary hydrolysate; adding rice saccharified liquid, soy sauce aroma enhancing yeast and lactic acid bacteria to the secondary hydrolysate, performing aroma-enhancing enzymatic hydrolysis at 40-55 DEG C for 20-30 h, and sterilizing to obtain mixed fermentation broth; flavoring and thickening the mixed fermentation broth to obtain the creamy fermented bean curd. The creamy fermented bean curd has little edible salt and good flavor, is significantly lower in salinity than common fermented bean curd, is better in health and safety, takes short time to produce, and has higher industrial production value.

The present invention relates to a carboxyl-containing vinyl chloride copolymer resin. This carboxyl-containing vinyl chloride copolymer resin has a chemical structure represented by formula (1): avinyl chloride based structural unit (a) and a structural unit (b) based on a monomer represented by a formula (2) are included, CR1R2=CR3R4COOH (2) (in formula (2), R1 is selected from hydrogen, methyl,benzene ring, R2 is selected from hydrogen, methyl, a linear or branched alkyl group having 1-15 carbon atoms, R3 is selected from hydrogen and methyl, and R4 is selected from linear or branched alkyl or alkylene with the carbon number of 0-15. The content of the structural unit (b) is 1-20% by mass relative to the total mass of the carboxyl-containing vinyl chloride copolymer resin.

The invention provides an ABS chromium-free coarsening solution. The coarsening solution is an aqueous solution containing manganese sulfate, sulfuric acid, phosphoric acid and methanesulfonic acid. The invention further provides a coarsening method of the chromium-free coarsening solution for ABS plastic. The prepared chromium-free coarsening solution is electrolyzed by an electrolysis device, the ABS plastic is placed in the coarsening solution for chemical coarsening, and the chromium-free coarsening solution needs to be connected with evaporation equipment so as to maintain the specific gravity of the solution. According to the coarsening solution, the environmental pollution caused by conventional chromium acid coarsening and the use of explosive raw materials such as potassium permanganate are avoided, the coarsening method improves the stability of coarsening liquid and coarsening capability, and the ABS chromium-free coarsening solution has good coarsening effect and industrialapplication value.

The invention relates to a three-channel pulverized coal burner. The three-channel pulverized coal burner comprises an outer-layer pipeline, a middle-layer pipeline, an inner-layer pipeline, an inner-layer pipeline feeding branch pipe, a middle-layer pipeline feeding branch pipe, an outer-layer pipeline feeding branch pipe, a connecting flange I, a connecting flange II, a sealing flange, a controlbutterfly valve I, a control butterfly valve II, a control butterfly valve III, rotational flow pieces and a pore plate. Three sleeves are sequentially connected in a sleeved mode from inside to outside, reinforcing ribs are arranged on the outer side of the outer-layer pipeline, supporting pieces are arranged between the outer-layer pipeline at the front end of the three-channel pulverized coalburner and the middle-layer pipeline, the rotational flow pieces are arranged between the middle-layer pipeline and the inner-layer pipeline, and the pore plate is arranged at the front end of an inner-layer pulverized coal channel. The three-channel pulverized coal burner has the advantages that the shapes and the lengths of flames in the three sleeves can be adjusted by adjusting the opening degrees of the inner-layer control butterfly valve, the middle-layer control butterfly valve and the outer-layer control butterfly valve, the combustion speed of pulverized coal can be controlled to be moderate without adding external combustion-supporting air, and then the temperature distribution in a rotary kiln is uniform.

The invention relates to an air filter stick provided with resistance-increasing fixed pieces. Multiple resistance-increasing fixed pieces are arranged in the air filter stick and parallelly and orderly arranged in the air filter stick. An air channel is arranged in the axial direction. The resistance-increasing fixed pieces are rolled to be cylindrical by using forming paper, and a cavity is formed between every two adjacent resistance-increasing fixed pieces. By adopting unique micropores, the smoke flowing speed is improved, a smoke flowing state is changed, and then a part of tar and other harmful substance settles and is absorbed.

The invention discloses a synthesis process of methyl-3-(3-tert-butyl-4-hydroxy) phenylpropionate, which comprises the following steps of mixing methyl p-hydroxyphenylpropionate and tert-butyl alcoholaccording to a certain molar ratio, and carrying out continuous reaction in a tubular fixed bed reactor filled with a solid catalyst to obtain a crude product of methyl 3-(3-tert-butyl-4-hydroxy) phenylpropionate, and distilling to remove water with a low boiling point, carrying out secondary separation on residual tert-butyl alcohol through a rectifying tower to obtain a methyl 3-(3-tert-butyl-4-hydroxy) phenylpropionate product. According to the synthesis process, methyl p-hydroxyphenylpropionate and tert-butyl alcohol are used as raw materials, granular solid sulfonic acid resin is used, continuous reaction is performed, secondary separation is performed through a rectifying tower, a high-purity methyl 3-(3-tert-butyl-4-hydroxy) phenylpropionate product is obtained, the yield is high,the quality is excellent, unreacted methyl p-hydroxyphenyl propionate is recycled, so that the method has good industrial production value, and the production cost is reduced.