58 results about "Tirofiban Hydrochloride" patented technology

The invention relates to an injection for inhibiting platelet aggregation and its preparation process, wherein the injection comprises Tirofiban Hydrochloride, water and sodium chloride, and is prepared through the steps of, weighing sodium chloride by formula amount, charging into 5000ml water, stirring to complete dissolving, weighing activated charcoal 0.3% of the solution amount, and homogenizing, heating and boiling for 15 minutes, cooling down, filtering the activated charcoal, accurately weighing Tirofiban Hydrochloride by formula amount, dissolving completely with water, charging into the sodium chloride solution, and watering to near total amount, adjusting the pH to 5.5-6.5 with hydrochloric acid, watering to specified amount, filtering with 0.45 um microporous filtration film, split charging into bottle, sterilizing 35 minutes through hot compression at 115 deg. C.

The preparation method of tirofiban hydrochloride freeze-dried powder injection preparation includes the following steps: using 30-1200g of lactose, adding water for injection, dissolving, adding active carbon, stirring for 10-60 min at 25-100deg.C, filtering and removing carbon, adding 5.62g of tirofiban hydrochloride monohydrate, stirring, adding water for injection to 1500-4000ml, regulating pH value of solution to 2-3, sterile filtering, filling, freeze-drying, squeezing cap and packaging, etc.

The invention relates to a tirofiban hydrochloride lyophilized powder injection and a preparation method thereof, belonging to the field of western medicine preparation. The tirofiban hydrochloride lyophilized powder injection contains 1 part by weight of tirofiban hydrochloride and 0.5-100 parts by weight of dextran, and the pH value of solution before lyophilization is 1.8-2.6. Preferably, the weight ratio between the dextran and the tirofiban hydrochloride is 2:1-20:1. The tirofiban hydrochloride lyophilized powder injection has good composite dissolubility and stability as well as high safety.

The invention discloses a method suitable for industrial production of tirofiban hydrochloride, a medicine for treating angina pectoris.

A powder injection for suppressing the thrombocyte coagulation is proportionally prepared from tirofiban hydrochloride, the water for injection and the pharmacologically acceptable carrier chosen from lactose, mannitol, cane sugar, glucose, dextran, hydrolytic gelatin and sodium chloride through proportionally mixing, examining intermediate, adding water, filtering, loading in bottle and vacuum freeze drying.