35 results about "Melanosome" patented technology

The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a Malassezia yeast, and chemical analogs thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an arylhydrocarbon receptor (AhR), improve hyperpigmentation caused by a hyperpigmentation disorder, and modulate melanin production, melanosome biogenesis, and melanosome transfer.

The invention relates to the field of cosmetics and provides a co-conveying nano composition of phenylethyl resorcinol. The co-conveying nano composition comprises phenylethyl resorcinol, other skin whitening active components, a nano medicine carrier as well as solvent complex lipid and water, wherein the phenylethyl resorcinol accounts for 0.1-10% of the total mass of the co-conveying nano composition; the other skin whitening active components comprise at least one of an antioxidant, a cutin peeling type active substance, a melanosome transferring inhibition active substance, an anti-glycation active substance and an anti-allergic agent; the nano medicine carrier comprises raw materials of an emulsifier, a Anti-allergic agent and polyhydric alcohols. Due to compounding of different skinwhitening components and carrying of the nano medicine carrier, a remarkable synergetic effect can be achieved, irritation of high-concentration phenylethyl resorcinol can be remarkably reduced, andthe co-conveying nano composition is good in stability, excellent in skin whitening effect, good in water solubility, good in skin permeability and widely applicable to cosmetics.

The invention provides whitening essence containing bearberry extract lipid nanoemulsion. The whitening essence is prepared from a component A, a component B and a component C, wherein the component A comprises arbutin lipid nanoemulsion, antioxidant biological active peptide, vitamin C and the like; the component B is selected from glycerinum, glycerin monostearate, hexadecyl alcohol, squalane, licoflavone, vitamin E, microcrystalline wax and the like; the component C is selected from avocado oil, silicon oil, vitamin E, stearate, hexadecyl alcohol, Vaseline, beeswax, lanum and the like. The whitening essence does not contain chemical ultraviolet absorbent and is a pure natural cosmetic composition by use of plant whitening agent and biological active peptide as functional components, the bearberry extract based whitening essence can reduce the tyrosinase activity and inhibit melanosome maturity, and can be further effectively combined with licoflavone and biological active peptide, thereby achieving good whitening effect.

The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a Malassezia yeast, and chemical analogs thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an arylhydrocarbon receptor (AhR), improve hyperpigmentation caused by a hyperpigmentation disorder, and modulate melanin production, melanosome biogenesis, and melanosome transfer.

The invention is directed to a method and composition suitable for skin color modulation. Particularly, the action of D-dopachrome tautomerase on melanogenesis and / or the transfer of melanin from melanosomes in keratinocytes is reduced, thereby resulting in a change in skin color.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The present invention is in the field of personal care compositions; in particular skin lightening compositions. It is believed that niacinamide reduces the melanosome transfer from melanocytes to keratinocytes thereby bringing about skin lightening. However, niacinamide is known to have little or no effect directly on the melanin content in the melanocytes. Thus a composition with multiple modes of action, that combines the reduction of melanosome transfer and the reduction of melanin content in the melanocytes remains to be desired. It is therefore an object of the present invention to provide a composition with synergistic amounts of picolinamide and niacinamide, providing improved melanosome transfer inhibition. It has been found that a synergistic skin lightening effect is obtained when niacinamide is combined with its isomer, picolinamide.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating aylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The invention discloses a preparation method of human hair melanosomes derivatives (HHMs). The preparation method comprises the following steps of step 1, pretreatment: crushing, cleaning and drying human hair; step 2, hydrothermal reaction: carrying out hydrothermal reaction on the pretreated human hair in a NaOH solution; and 3, separation: carrying out centrifugal separation and vacuum drying on a solid sample material obtained after the hydrothermal reaction to obtain HHMs. The invention relates to a preparation method of a human hair melanosomes derivative-lysozyme (HHMs-Lyso) composite material. The preparation method comprises the following steps of uniformly dispersing prepared HHMs into deionized water to obtain a first feed liquid; dispersing lysozyme into deionized water to obtain second feed liquid; and mixing the first feed liquid and the second feed liquid in an isopyknic manner to obtain the HHMs-Lyso. According to the HHMs prepared through the method, MRSA can be efficiently killed by loading Lyso, and meanwhile tissue repair can be promoted through the HHMs.

The invention describes a method to modulate melanosome maturation process in melanocytes. Further, it describes a method to reversibly alter the process of pigmentation in the human epidermal skin. The method targets melanosome maturation and its transfer to keratinocytes, which are key processes involved in the pigmentation for its potential use in predictable and controlled regulation of pigmentation in human skin.

Provided is a composition. The composition comprises a compound having the structure of Formula (1). The composition reduces the synthesis of melanin by inhibiting the activity and expression levels of tyrosinase and related proteins, thereby preventing and limiting the content and distribution of melanin in mammalian skin. It also induces autophagy of melanosome, thereby restricting the synthesis, storage and transfer of melanin from melanocyte to keratinocyte. The dual modes of action allow for the efficacy of the composition at low dosage without causing toxicity to lighten skin and treat disorders associated with hyperpigmentation.

The present invention is in the field of personal care compositions; in particular skin lightening compositions. It is believed that niacinamide reduces the melanosome transfer from melanocytes to keratinocytes thereby bringing about skin lightening. However, niacinamide is known to have little or no effect directly on the melanin content in the melanocytes. Thus a composition with multiple modes of action, that combines the reduction of melanosome transfer and the reduction of melanin content in the melanocytes remains to be desired. It is therefore an object of the present invention to provide a composition with synergistic amounts of picolinamide and niacinamide, providing improved melanosome transfer inhibition. It has been found that a synergistic skin lightening effect is obtained when niacinamide is combined with its isomer, picolinamide.

The invention discloses a cosmetic composition with a whitening effect and application thereof. The cosmetic composition with the whitening effect is prepared from the following components in percentage by mass: 0.1 to 5 percent of nicotinamide, 0.002 to 0.5 percent of tocopherol / tocopherol, 0.002 to 5 percent of sucrose dilaurate and pea extract and 90 to 99.9 percent of cosmetic auxiliary material matrix. According to the cosmetic composition disclosed by the invention, by utilizing a synergistic interaction effect of the nicotinamide, the tocopherol / tocopherol, the sucrose dilaurate and the pea extract, through inhibiting synthesis of melanin and melanosomes, inhibiting melanosome migration, resisting oxidization and resisting damages, caused by free radicals, to skin, resisting ultraviolet damages, realizing comprehensive light protection, strengthening a skin barrier and the like, the cosmetic composition can be used for efficiently and uniformly brightening skin color and enabling the skin to be more and more exquisite and perfect. The cosmetic composition disclosed by the invention is applied to sunscreen cosmetics, so that the whitening effect is expressed and the sunscreen performance of the sunscreen cosmetics also can be improved.

The invention discloses moisturizing water and a preparation method thereof. The moisturizing water is composed of 20-30 wt% of rose water, 3-4 wt% of panthenol, 1-3 wt% of butylene glycol, 1-2 wt% of cynara scolymus leaf extract, 1-2 wt% of glycosphingolipid, 0.1-0.3 wt% of sodium citrate, 0.08-0.12 wt% of citric acid, 0.05-0.15 wt% of a saccharide isomeride, 0.001-0.003 wt% of protease, 0.001-0.003 wt% of protease dextran, 0.0001-0.00015 wt% of a colorant and the balance of water. The moisturizing water combines toning lotion and essence functions, realizes cutin conditioning, permeates and enters skin to activate skin, effectively inhibits the stimulating substances, blocks the formation of melanin, promotes epidermal cell activation, fast discharges melanosomes, relieves redness and inflammation caused by solarization, improves dryness and roughness caused by aging, improves skin brightness from inside to outside, shrinks pores to lock water and preserve moisture, has effects of activation, moisturizing, balance and conditioning and is suitable for all skin types and skin ages.

The present invention relates to the field of cosmetics, and provides a co-delivery nanocomposition of α-arbutin, including α-arbutin, other whitening active ingredients and nano drug-carrying carriers; the α-arbutin accounts for the co-delivery 0.05-20.0% of the total mass of the nano composition; the other whitening active ingredients include tyrosinase inhibitors, melanosome migration inhibitors, antioxidants, anti-glycation active substances and At least one of the anti-inflammatory agent; the raw material of the nano-loaded drug carrier includes emulsifier and co-emulsifier; also includes oil and water. The present invention achieves a significant synergistic effect through the compounding of different whitening mechanisms and the loading of nano drug-loaded carriers, and significantly reduces the skin melanin content through multi-target effects, and the co-delivery nanocomposition can realize the sustained release of drugs And controlled release, large drug loading, good stability, good water solubility and skin permeability, excellent whitening effect, and can be widely used in cosmetics.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia- derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The invention relates to a composition for inhibiting PAR-2 from activating keratinocytes and an application of the composition to facial masks, and provides a composition for inhibiting PAR-2 from activating keratinocytes. The composition comprises trehalose, bio-saccharide gum-1, nicotinamide and tranexamic acid. PAR-2 is used as an action target, by inhibiting the activity of PAR-2, the mediation effect of PAR-2 on melanin transport is influenced, the phagocytosis of keratinocytes activated by PAR-2 on melanin bodies is inhibited, accumulation and deposition of melanin in cuticle are hindered, and the pigmentation problem in the state of ultraviolet irradiation or skin inflammation is prevented. The composition is also applied to a facial mask, and the facial mask for inhibiting hyperpigmentation is provided. A test experiment shows that the facial mask disclosed by the invention has an inhibiting effect on PAR-2 activity, melanogenesis and chromatosis, and is relatively good in product safety.

The invention relates to the field of cosmetics and provides a co-conveying nano composition of phenylethyl resorcinol. The co-conveying nano composition comprises phenylethyl resorcinol, other skin whitening active components, a nano medicine carrier as well as solvent complex lipid and water, wherein the phenylethyl resorcinol accounts for 0.1-10% of the total mass of the co-conveying nano composition; the other skin whitening active components comprise at least one of an antioxidant, a cutin peeling type active substance, a melanosome transferring inhibition active substance, an anti-glycation active substance and an anti-allergic agent; the nano medicine carrier comprises raw materials of an emulsifier, a Anti-allergic agent and polyhydric alcohols. Due to compounding of different skinwhitening components and carrying of the nano medicine carrier, a remarkable synergetic effect can be achieved, irritation of high-concentration phenylethyl resorcinol can be remarkably reduced, andthe co-conveying nano composition is good in stability, excellent in skin whitening effect, good in water solubility, good in skin permeability and widely applicable to cosmetics.

Disclosed herein are an external composition for skin, which contains, as an active ingredient, manassantin B extracted from Saururus chinensis Baill, and the use thereof for skin whitening. More particularly, disclosed are an external composition for skin, which contains, as an active ingredient, manassantin B, which inhibits the transfer of melanosomes, thus providing a skin-whitening effect without influencing the melanin synthesis function of the melanocytes, as well as the use thereof for skin whitening.

Disclosed herein are an external composition for skin, which contains, as an active ingredient, manassantin B extracted from Saururus chinensis Baill, and the use thereof for skin whitening. More particularly, disclosed are an external composition for skin, which contains, as an active ingredient, manassantin B, which inhibits the transfer of melanosomes, thus providing a skin-whitening effect without influencing the melanin synthesis function of the melanocytes, ad well as the use thereof for skin whitening.

The invention belongs to the field of cosmetics, and discloses a carnosine-containing composition and eye cream containing the carnosine-containing composition. The composition comprises the followingcomponents: carnosine, palmitoyl polypeptide, nicotinamide and a solvent. According to the invention, carnosine, palmitoyl polypeptide and nicotinamide are compounded to remove dark circles and improve the eye skin state. The generation of AGEs is inhibited by carnosine; furthermore, the carnosine is combined with the formed AGEs to inactivate the AGEs; nicotinamide is used for inhibiting melanosome from migrating to the surface of the skin; and palmitoyl polypeptide is used for regulating maturation and differentiation of epidermis, preventing aggregation and denaturation of protein and preventing roughening of the skin surface. The eye cream containing the composition can be used for effectively improving long-term dark circles and preventing aging of eye skin.

The invention is directed to compositions and methods for increasing the pH of a melanosome in a melanocyte, darkening skin or hair pigmentation, or treating a disease associated with decreased melanin comprising administering a soluble adenylyl cyclase (sAC) inhibitor and / or an exchange protein activated by cyclic AMP (EPAC) inhibitor to the melanocyte. The invention also provides compositions and methods for decreasing the pH of a melanosome in a melanocyte, lightening skin or hair pigmentation, or treating a disease associated with increased melanin comprising administering a sAC activator and / or an EPAC activator to the melanocyte.

The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia-derived compounds, including malassezin and indirubin, and / or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

The invention relates to a whitening composition and its preparation method and application. In terms of the mass percentage of the whitening composition, the whitening composition includes the following components: emblica extract: 0.01%-10%, soybean extract: 0.01%-20%, aloin: 0.01%-5% %, ascorbic acid ethyl ether: 0.3% to 5%, nicotinamide: 0.5% to 20%. The whitening composition of the present invention can achieve a balanced whitening effect, that is, it can comprehensively consider all aspects of skin whitening. Specifically, it can start from the process of melanin production, reduce melanin, block the transfer process of melanin, induce and block the protease-activated receptor-2 channel, reduce the phagocytosis of melanosomes by keratinocytes, reduce the transport of melanin, and prevent melanin from entering the cutin Layers and other aspects play a role.

The invention relates to a novel compound, and a cosmetic composition and a pharmaceutical composition comprising the same. Disclosed are a novel compound, and a cosmetic composition for whitening anda pharmaceutical composition for preventing and treating a melanin hyperpigmentation disorder by activating autophagy to induce melanosome degradation and also by effectively inhibiting endocytosis of keratinocytes to interfere melanosome transfer into keratinocytes, thereby expressing an excellent effect on improvement, prevention, and treatment of a hyperpigmentation disorder induced from melanin.

The invention is directed to a method and composition suitable for skin color modulation. Particularly, the action of D-dopachrome tautomerase on melanogenesis and / or the transfer of melanin from melanosomes in keratinocytes is reduced, thereby resulting in a change in skin color.