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Production method of odor-masking enrofloxacin

A production method and gelatin technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of poor palatability, unsuitability for oral use in pigs, affecting convenience and economy, and the like. palatable effect

Inactive Publication Date: 2006-10-04
XINCHANG GUOBANG CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral enrofloxacin is favored by breeders because of its convenience, practicality, and ease of operation. However, the existing oral enrofloxacin has poor palatability. Pigs will not eat after smelling the smell, even after feeding, they will vomit, so it is especially not suitable for oral use by pigs
This limits the field of application of enrofloxacin, affecting the convenience and economy of its use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1, a kind of production method of taste-masking enrofloxacin comprises the following steps:

[0013] 1) Dissolve 27kg of gelatin in 80kg of warm water, heat at 40°C for 0.5 to 1 hour to dissolve the gelatin; then add 4kg of glycerin, stir at 40°C to obtain gelatin slurry;

[0014] 2), add 100ml concentration in above-mentioned gelatin pulp and be the ethyl p-hydroxybenzoate ethanol solution of 6% (weight / volume), form gelatin-plasticizer composite solution after mixing, and regulate described gelatin-plasticizer with alkali The pH value of the composite solution is 7;

[0015] 3), heat 180kg of water to 75°C in the reactor, add 30kg of enrofloxacin and stir evenly, then add 39kg of silicon dioxide (white carbon black) and stir for 5 minutes to form a suspension; then mix the above The temperature in the reaction kettle was lowered to 50°C, and the pH value of the suspension was adjusted to 7 with alkali;

[0016] 4), the gelatin-plasticizer composite soluti...

Embodiment 2

[0019] Embodiment 2, a kind of production method of taste-masking enrofloxacin, comprises the following steps:

[0020] 1) Dissolve 15kg of gelatin in 80kg of warm water, heat at 40°C for 0.5 to 1 hour to dissolve the gelatin; then add 2kg of glycerin, stir at 40°C to obtain gelatin slurry;

[0021] 2), adding 50ml of ethyl p-hydroxybenzoate ethanol solution with a concentration of 6% (weight / volume) in the above-mentioned gelatin slurry, forming a gelatin-plasticizer composite solution after mixing, and adjusting the gelatin-plasticizer with alkali The pH value of the composite solution is 7.2;

[0022] 3), heat 180kg of water to 75°C in the reactor, put in 30kg of enrofloxacin and stir evenly, then put in 53kg of silicon dioxide (white carbon black) and stir for 5 minutes to form a suspension; then mix the above The temperature in the reaction kettle was lowered to 50°C, and the pH value of the suspension was adjusted to 7.2 with alkali;

[0023] 4), put the gelatin-plasti...

Embodiment 3

[0026] Embodiment 3, a kind of production method of taste-masking enrofloxacin, comprises the following steps:

[0027] 1) Dissolve 35kg of gelatin in 80kg of warm water, heat at 40°C for 0.5-1 hour to dissolve the gelatin; then add 5kg of glycerin, stir at 40°C to obtain gelatin slurry;

[0028] 2), add 100ml concentration in above-mentioned gelatin pulp and be the ethyl p-hydroxybenzoate ethanol solution of 6% (weight / volume), form gelatin-plasticizer composite solution after mixing, and regulate described gelatin-plasticizer with alkali The pH value of the composite solution is 6.9;

[0029] 3) In the reactor, heat 180kg of water to 75°C, put in 30kg of enrofloxacin and stir evenly, then put in 30kg of silicon dioxide (white carbon black) and stir for 5 minutes to form a suspension; then mix the above The temperature in the reaction kettle was lowered to 50°C, and the pH value of the suspension was adjusted to 6.9 with alkali;

[0030] 4), the gelatin-plasticizer composit...

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PUM

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Abstract

The invention discloses a process for producing masked Enrofloxacin comprises the following steps, (1) charging gelatin into water, (1) thermally insulating 0.5-1 hour at 30-50 deg C., charging glycerin, thermally insulating at 30-50 deg C, stirring to obtain gelatine size, (2) charging 6% of p-hydroxybenzoic acid ethyl ester ethanol solution, mixing to form gelatin-plasticizer composite solution, adjusting the pH to 6.8-7.2 with alkali, (3) charging water into autoclave, heating to 70-80 deg C, charging Enrofloxacin, stirring and charging silicon dioxide, stirring to form turbid liquor, cooling down to 45-55 deg C, adjusting pH to 6.8-7.2 with alkali, (4) charging gelatin-plasticizer composite solution into the turbid liquor, hardening 25-35 minutes with 5.37% of formaldehyde solution.

Description

technical field [0001] The invention relates to a production method of enrofloxacin, in particular to a production method of taste-masked enrofloxacin. Background technique [0002] Enrofloxacin, as an animal-specific antibacterial drug, can be injected or taken orally. Its mechanism of action is different from the previous antibacterial drugs and antibiotics. It acts directly on the nucleus of bacteria and inhibits the DNA gyrase of bacteria; so that the enzyme cannot introduce nicks on the DNA double strands and then reseal them. Therefore, enrofloxacin destroys the metabolism and proliferation of bacteria from the depth of the bacterial nucleus, can quickly kill bacteria, has stable bactericidal effect, good antibacterial effect, and low treatment cost. It can be widely used in the treatment of diseases of poultry and livestock, and has remarkable effects on the treatment of yellow scour and pullorum of piglets, swine edema, mycoplasma pneumonia, chicken mycoplasma disea...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K47/42A61P31/04
Inventor 竺亚庆杨红初
Owner XINCHANG GUOBANG CHEM IND
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