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Production method for tasteless enteric enrofloxacin microcapsules

A technology of enrofloxacin and its production method, which is applied in the direction of animal feed, additional food elements, animal feed, etc., can solve the problems of not being applied, affecting the feed intake of pigs, etc., and achieve the effect of prolonging the action time

Inactive Publication Date: 2011-02-09
WUXI ZHENGDA POULTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, enrofloxacin has a strong bitter taste, and adding it to the feed seriously affects the feed intake of pigs, so this product cannot be used in pig farms

Method used

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  • Production method for tasteless enteric enrofloxacin microcapsules
  • Production method for tasteless enteric enrofloxacin microcapsules
  • Production method for tasteless enteric enrofloxacin microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] First weigh 50kg of enrofloxacin, dissolve it in 4kg of sodium hydroxide solution with a concentration of 1mol / l, add 8kg of molten stearic acid at 45°C, and stir evenly at room temperature to make enrofloxacin stearin acid mixture. Add 25kg of starch to the above enrofloxacin stearic acid mixture as an auxiliary material for granulation and spheronization. During the spheronization process, spray 12kg of the second layer of enteric coating agent acrylic resin on the surface of the granules to obtain approximately spherical microcapsule particles , the diameter of the microcapsule particles is 50-400 μm. The obtained semi-finished product of tasteless enteric-coated enrofloxacin microcapsule granules is dried to obtain the final product.

Embodiment 2

[0027] First weigh 60kg of enrofloxacin, dissolve it in 5kg of sodium hydroxide solution with a concentration of 1.1mol / l, add 10kg of molten stearic acid at 50°C, and stir evenly at room temperature to make enrofloxacin stearin acid mixture. Add 10kg of starch to the above enrofloxacin stearic acid mixture as an auxiliary material for granulation and spheronization. During the spheronization process, spray 5kg of the second layer of enteric coating agent acrylic resin on the surface of the granules to obtain approximately spherical microcapsule particles , the diameter of the microcapsule particles is 50-400 μm. The obtained semi-finished product of tasteless enteric-coated enrofloxacin microcapsule granules is dried to obtain the final product.

Embodiment 3

[0029] First weigh 70kg of enrofloxacin, dissolve it in 6kg of sodium hydroxide solution with a concentration of 1.2mol / l, add 12kg of molten stearic acid at 55°C, and stir evenly at room temperature to make enrofloxacin stearin acid mixture. Add 10kg of starch to the above-mentioned enrofloxacin stearic acid mixture as an auxiliary material for granulation and spheronization. During the spheronization process, spray 2kg of the second layer of enteric coating agent acrylic resin on the surface of the granules to obtain approximately spherical microcapsule particles , the diameter of the microcapsule particles is 50-400 μm. The obtained semi-finished product of tasteless enteric-coated enrofloxacin microcapsule granules is dried to obtain the final product.

[0030] figure 2 The absorption characteristics of enrofloxacin with different processing techniques are shown. Depend on figure 2 Visible, under the situation of same dosage, the enrofloxacin microcapsule that adopts...

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Abstract

The invention relates to a production method for tasteless enteric enrofloxacin microcapsules, which comprises the following technical steps: (1) dissolving enrofloxacin to alkali liquor and adding stearic acid in a molten state for a first envelop; (2) mixing with auxiliary materials for pelletizing and rounding, and adding a coating agent for a second layer of envelop in the course of rounding; and (3) baking semi-finished products to obtain finished products. The production method of the invention has the advantages that macromolecular substances are utilized to envelop the enrofloxacin to isolate the enrofloxacin from the external environment, thus not only covering the strong bitterness of the enrofloxacin, but also having no influence on feed palatability; and the enveloped enrofloxacin microcapsules are not dissolved in the acid environment and gradually dissolved in the alkaline environment of the intestinal tract so as to reach the purpose of slow release and prolong the action time of the enrofloxacin.

Description

technical field [0001] The invention relates to the technical field of feed and feed additives, in particular to a production method of tasteless enteric-coated enrofloxacin microcapsules. Background technique [0002] Enrofloxacin, also known as ethyl ciprofloxacin and enrofloxacin, is named 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4- Dihydro-4-oxo-3-quinolinecarboxylic acid is currently designated as a special drug for animals by the state. Enrofloxacin is a broad-spectrum bactericidal drug, which has special effects on mycoplasma, and has bactericidal effects on Escherichia coli, Staphylococcus aureus, and streptococci. However, enrofloxacin has a strong bitter taste, and adding it to the feed seriously affects the feed intake of pigs, so this product cannot be used in pig farms. Contents of the invention [0003] Aiming at the above-mentioned defects existing in the existing enrofloxacin, the applicant of the present invention has carried out improved resea...

Claims

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Application Information

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IPC IPC(8): A23K1/17A23K20/195
Inventor 周玲
Owner WUXI ZHENGDA POULTRY
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