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A core-shell alginate/polyacrylamide microsphere loaded with andrographolide and its preparation method and application

A technology of andrographolide and polyacrylamide, which is applied in the field of preparation of new drug dosage forms, can solve the problems that small molecular components have no ideal controlled release ability, can not achieve the taste masking effect of encapsulated andrographolide, and increase clinical application The effect of range, controllable microsphere size and high encapsulation efficiency

Active Publication Date: 2020-07-14
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this polyelectrolyte film can effectively shield the leakage of encapsulated cells in microspheres and control the release rate of macromolecular components such as proteins, nucleic acids, and polysaccharides, it does not have ideal controlled release capabilities for small molecular components. Therefore, The taste-masking effect of encapsulated andrographolide cannot be achieved by using traditional polylysine / calcium alginate or chitosan / calcium alginate microspheres

Method used

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  • A core-shell alginate/polyacrylamide microsphere loaded with andrographolide and its preparation method and application
  • A core-shell alginate/polyacrylamide microsphere loaded with andrographolide and its preparation method and application
  • A core-shell alginate/polyacrylamide microsphere loaded with andrographolide and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of calcium alginate microspheres by electrostatic field droplet method:

[0048] Connect the positive pole of the pulsed electric field to the metal needle of a syringe loaded with 10mL of 1% sodium alginate and 0.1g of andrographolide mixed solution (raw material solution), and connect the negative pole of the electric field to 3% CaCl 2 The metal coils in the solution (gel bath) are connected so that an electrostatic field is formed between the stock solution and the gel bath. A micro-syringe pump is used to pump the raw material solution through a metal needle at a rate of 10 mL / h. Under the action of an electric field force, the raw material solution overcomes the surface tension of the solution and is sprayed into the coagulation bath in the form of droplets with controllable size. Sodium alginate and Ca in droplets 2+ Cross-linking and forming calcium alginate, which is insoluble in water, the droplets solidify to form microspheres and encapsulate the...

Embodiment 2

[0050] see figure 2 , to prepare alginate / polyacrylamide microspheres by electrostatic droplet method:

[0051] Connect the positive electrode of the pulsed electric field to the metal needle of the syringe loaded with 10mL of 1% sodium alginate and 0.1g of andrographolide mixed solution (raw material solution), and connect the negative electrode of the electric field to 3% CaCl containing 1.4g of acrylamide monomer in 25mL 2 The metal coils in the solution (gel bath) are connected so that an electrostatic field is formed between the stock solution and the gel bath. A micro-syringe pump is used to pump the raw material solution through a metal needle at a rate of 10 mL / h. Under the action of an electric field force, the raw material solution overcomes the surface tension of the solution and is sprayed into the coagulation bath in the form of droplets with controllable size. Sodium alginate and Ca in droplets 2+ Cross-linking and forming calcium alginate, which is insoluble ...

Embodiment 3

[0056] Determination of the release rate of andrographolide in calcium alginate microspheres and alginate / polyacrylamide microspheres by UV spectrophotometer:

[0057] The alginate / polyacrylamide microspheres and calcium alginate microspheres prepared in Example 1 and Example 2 were immersed in a beaker containing 30 mL of distilled water, and placed in a shaker at 37°C to shake fully. After 5min, pipette 3mL of aqueous solution from the beaker, and add 3mL of distilled water to the beaker. The experimental procedure was repeated at 10 min, 20 min, 30 min, 45 min, 1 h, 2 h, 3 h, 4 h, 5 h, 6 h, 8 h, 10 h, 12 h, 24 h. Measure the absorbance value of two kinds of microspheres in distilled water at wavelength 226nm respectively, according to the absorbance value and concentration relation standard curve of andrographolide in distilled water and calculate its corresponding concentration, draw andrographolide in two kinds of microspheres release curve in . See results Image 6 , ...

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Abstract

The invention discloses a core-shell alginate / polyacrylamide microsphere loaded with andrographolide, a preparation method and application thereof, and belongs to the technical field of preparation of new drug dosage forms. The microsphere is made of the following components: sodium alginate, polyacrylamide, andrographolide. The preparation method of the alginate / polyacrylamide microspheres loaded with andrographolide of the present invention is an electrostatic droplet method, which has the advantages of high microsphere preparation efficiency, mild preparation conditions, controllable microsphere size, high microsphere loading efficiency, and stable performance. Good and other advantages, can be widely used in medical applications. The microspheres prepared by the invention can be used to treat diseases such as infantile pneumonia and upper respiratory tract infection, have functions such as immune regulation and anti-tumor, and can be widely used in the fields of health care products, medicines, biomedical materials and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of new drug dosage forms, and relates to a polymer microsphere and a preparation method thereof, in particular to a core-shell type alginate / polyacrylamide microsphere loaded with andrographolide, a preparation method and application thereof. Background technique [0002] Andrographolide (C 20 h 30 O 5 ) is a diterpene lactone compound extracted from the Acanthaceae plant Andrographis paniculata. It is one of the main active ingredients of the traditional Chinese medicine Andrographis paniculata. The chemical structure is shown in Figure 1A . Andrographolide has antipyretic, anti-inflammatory, antiviral, hepatoprotective and choleretic effects, and is mainly used clinically to treat upper respiratory tract infection, pneumonia and other diseases. Andrographolide is prismatic or flaky crystal, odorless, very bitter taste, soluble in acetone, methanol, ethanol, almost insoluble in water, mel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/365A61K47/36A61K47/32A61P11/00A61P31/00
CPCA61K9/5026A61K31/365A61K47/36
Inventor 薛伟明张梦晨温惠云黄赛朋贾朝许宁侠
Owner NORTHWEST UNIV
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