35results about How to "Has a sensitizing effect" patented technology

The invention discloses a temperature self-compensating double grating symmetrical push-pull type fiber grating vibrating sensor. The invention aims to realize a fiber grating vibrating sensor which has the function of temperature self-compensation and has high sensitivity and favorable low-frequency detection performance. The fiber grating vibrating sensor is composed of a shell, two elastic body blocks, a mass block, two sensing fiber Bragg gratings, two connecting seats and two support bases, wherein the mass block is positioned between the two elastic body blocks; the connecting seats are respectively attached to two end faces of the mass block, and respectively abuts against and adheres to one end of each of the two elastic body blocks; and the other end of each of the two elastic body blocks abuts against and adheres to each of the two support bases, thereby constituting a symmetrical push-pull type structure; the positions carved with fiber Bragg gratings on the two fibers are respectively packaged in the two elastic body blocks; and the mass block, the connecting seats, the elastic body blocks, the fiber gratings and the support bases form a sensing probe and are arranged in the shell. The invention can eliminate the effect of temperature drift, has the advantages of high sensitivity, favorable low-frequency detection performance, and can conveniently expand to three dimensions.

The invention discloses water, ethanol and ethanol aqueous extracts of traditional Chinese medicine pithecellobium clypearia and application of corresponding petroleum ether, ethyl acetate, normal butanol and a water extractants in preparation of medicines for treating methicillin-resistant staphylococcus aureus (MRSA) and antibiotics anti-MRSA sensitization medicines. Meanwhile, the invention further discloses a preparation method of the extracts or extractants. Experimental results show that water, 10% ethanol, 30% ethanol, 60% ethanol, 95% ethanol extracts of pithecellobium clypearia and corresponding ethyl acetate, normal butanol and water extractants have stronger anti-MRSA effect, wherein the activity of the ethyl acetate extracting part of the 60% ethanol extract of pithecellobium clypearia is the strongest, and the ethyl acetate extracting part of the 60% ethanol extract of pithecellobium clypearia has sensitization effect on erythrocin, ceftriaxone sodium, levofloxacin for treating MRSA.

The invention discloses an MY type colloid emulsified civil explosive which comprises the following raw materials in percentage by weight: 35%-45% of ammonium nitrate, 6.5%-7.5% of sodium nitrate, 6%-10% of potassium nitrate, 15%-16% of flame inhibitors, 1.5% of urea, 3.5%-4% of emulsifying agents, 10% of water, 6%-6.3% of oil phases, 1.6%-1.8% of foaming agents, 0.15% of foaming promoters, 4.2%-4.4% of expanded perlite, 0.5% of mixed rare earth and 2.5%-6.5% of titanium hydride. The preparation process of the emulsified explosive comprises the steps of water phase preparation, oil phase preparation, emulsification, sensitization and charging. The MY type colloid emulsified civil explosive disclosed by the invention ensures the safety of the emulsified explosive, enhances the explosiveness and detonation sensitivity of the emulsified explosive and has high storage stability.

The invention discloses an application of nano-selenium serving as a CIK (cytokine-induced killer) cell sensitizer. The application of the nano-selenium serving as the CIK cell sensitizer refers to applying the nano-selenium as the CIK cell sensitizer to assist CIK cells. The nano-selenium provided by the invention is at least one of pure nano-selenium, polyethylene glycol modified nano-selenium, polyvinylpyrrolidone modified nano-selenium, chitosan modified nano-selenium, polysaccharide modified nano-selenium, folic acid modified tumor-targeting nano-selenium and transferrin modified tumor-targeting nano-selenium; and the CIK cells are obtained by performing mononuclear cell separation on human peripheral blood, bone marrow or cord blood, and performing induced culture by using a CD-3 antibody and IFN-gamma and IL-2 in vitro. The nano-selenium sensitizer disclosed by the invention has low-price and easily-available raw materials, synthesis and purification steps are strong in operability, and the synthesis scale can be appropriately enlarged by virtue of process optimization, thereby achieving commercialization and application of the medicine.

The invention discloses a compound photocatalyst Bi2S3 / BiOCl for ultraviolet catalytic degradation. Based on weight of the compound photocatalyst, Bi2S3 accounts for 10-40% in percentage by weight. The compound photocatalyst has a relatively strong ultraviolet catalytic degradation effect on sewage, particularly dye sewage, and the degradation rate can reach 94%. The compound photocatalyst is prepared by using a hydrothermal method, so that the synthesis of the compound photocatalyst has the advantages of simplicity in operation, conventional raw materials and easiness in realization.

The invention belongs to the field of pharmacy, relates to novel medicinal application of hydrogen sulfide and a donor thereof sodium hydrosulfide to pharmacy, and in particular relates to application of hydrogen sulfide and donor thereof sodium hydrosulfide to preparation of medicament for treating diabetes. The invention adopts the exogenous hydrogen sulfide and its donor sodium hydrosulfide (NaHS) for insulin sensibilization and tests for regulating blood sugar level and increasing insulin level for type II diabetes. Through correlation test of skeletal muscle and adipose cells with insulin resistance, insulin tolerance test by using animal model for diabetes insulin resistance, glucose consumption experiment, animal model experiment for diabetes insulin resistance and NaHS intervention animal experiment, the results show that NaHS can promote glucose uptake in the presence of insulin, thus indicating insulin enhancement effect. The invention of hydrogen sulfide and the donor thereof sodium hydrosulfide can be used as insulin sensitizers and medicaments for regulating blood sugar level and increasing insulin level for type II diabetes.

The invention discloses an ultrasound diagnosis and treatment system which comprises a master control center, an ultrasonic generator, a diagnosis and treatment integrated probe system and a signal processing center that are connected in sequence, wherein the diagnosis and treatment integrated probe system comprises an ultrasound triggering transducer and an ultrasonic imaging transducer which work in turns without interferences on each other, one end of the signal processing center is connected with the probe, while the other end of the signal processing center is connected with the master control center, the master control center controls the ultrasonic generator to emit ultrasonic waves, the ultrasonic waves are input to the probe through the ultrasound triggering transducer or the ultrasonic imaging transducer, the signals detected by the probe can return to the signal processing center for processing, and then the processed signals are fed back to the master control center. The invention further discloses a method for treating tumour by adopting the ultrasound diagnosis and treatment system. Compared with the prior art, the ultrasound diagnosis and treatment system realizes integration of ultrasound monitoring imaging and treatment and is widely applied to various ultrasound diagnosis and treatment methods, and the method for treating tumour by adopting ultrasound is greatly optimized.

The invention relates to a graphene sensitivity enhancing ITO metamaterial U-shaped SPR (Surface Plasmon Resonance) sensor, which comprises a U-shaped optical fiber, wherein the U-shaped area of the U-shaped optical fiber is provided with a Gr / Au@ITO nanorod hybrid material structure. The preparation method comprises the steps of (1) preparing a U-shaped optical fiber, and preparing a gold nanoparticle layer in the U-shaped area of the U-shaped optical fiber; (2) preparing an ITO nano array structure; and (3) loading a graphene layer. According to the invention, the U-shaped optical fiber is adopted to serve as a transmission medium of light, the Gr / Au@ITO nanorod hybrid material structure is prepared on the surface of the U-shaped optical fiber, the sensitivity of the SPR sensor is enhanced by the highly enhanced local electromagnetic field generated in nanometer gaps between the uniform nanorod structures, and the sensitivity is further enhanced by the carrier flow brought by the graphene layer. The sensor has the outstanding advantages of small volume, light weight, easy carrying, high sensitivity, stable property, strong and short biological affinity and the like, and has wideapplication prospect in the detection aspects of trace gases, liquid, chemical elements, DNA and the like in the fields of biology, chemical engineering, medicine and the like.

The invention discloses a preparation method of a BiOCl-TiO2 / Sb2S3 composite photocatalyst. According to the preparation method, with titanium butoxide, anhydrous ethanol, yttrium oxide, hydrochloricacid, H2S, BiCl3 and TiO2 / Sb2S3 as main raw materials, nanometer bismuth particles are produced in situ through combination of a solvothermal method and a hydrothermal method; the nanometer bismuth particles are uniformly distributed and densely bonded, so that the bismuth oxychloride composite photocatalyst has relatively high stability; the bismuth modification amount can be controlled by adjusting the temperature, the using amount of a reducing agent and other conditions; a preparation technology of the BiOCl-TiO2 / Sb2S3 composite photocatalyst is novel; by the preparation method, a good visible light degrading effect is achieved, and the cost and the pollution can be reduced; the preparation method has a good application prospect and good economic benefits in decomposition of organic pollutants.

The invention provides a novel garnet-based high efficiency green phosphor, a chemical formula is [(Gd1-xLux)1-yTby]Al5O12 (short for (Gd, Lu)AG:Tb<3+>), wherein x is Lu / (Gd+Lu+Tb) and y is Tb / (Gd+Lu+Tb)(x is 0-1.0, y is 0-0.15). The phosphor takes rare earth nitrate and an ammonium aluminium sulfate according to stoichiometric ratio to prepare a mother salting liquid, the mother salting liquid is dropped into a NH4HCO3 precipitating agent solution, the obtained deposition is centrifuged, washed, and dried to obtain the white precursor powder, and phosphor (Gd, Lu)AG:Tb<3+> can be obtained through calcining at different temperature. non radiation energy transmission of Gd<3+> to Tb<3+> is existed, the fluorescence quantum efficiency is high, addition of Lu can obvious improve the stability of a system, and is more suitable for a scintillator material.

According to the invention, an SD rat model infected by mycoplasma pneumoniae is adopted for experiments, and it is found that minor radix buplenri granules can remove excessive free radicals caused by mycoplasma pneumoniae infection. In particular, through combination of the minor radix buplenri granules and chloroquine phosphate, the levels of glutathione peroxidase, superoxide dismutase and catalase in serum can be obviously increased, and the content of malondialdehyde can be reduced, so that combined administration can improve the free radical removing capability of an organism and reducecytotoxicity generated by free radical accumulation. The minor radix buplenri granules combined chloroquine phosphate tablets have a purpose of removing excessive free radicals caused by mycoplasma pneumoniae infection, solve the problem of excessive free radicals in mycoplasma pneumoniae infection, have a better sensitization effect on azithromycin, and thus can be used for preventing and treating mycoplasma pneumoniae.

The invention discloses a novel material based on a natural diatom shell and phycobiliprotein and application. The method comprises the steps of removing organic matter contained in the diatom culturing shell; alkylating the diatom shell with APTES (3-aminopropyl trimethoxysilane), and making the alkylated diatom shell react with phycobiliprotein through BS3 (sulfosuccinyl iminooctanediate) to form covalent connection in order to achieve the purpose of fixing the phycobiliprotein to the diatom shell. The adopted diatom shell has the advantages of being convenient to obtain, relatively low in price, extremely high in biocompatibility, stability and reaction inertia and capable of achieving a certain light effect, so that a connected phycobiliprotein structure is more stable and has a sensitization effect.

The invention provides a fast detecting method of a vitamin K1 used for preventing coupling hemorrhage after vaccine injection.The method comprises the specific operation steps of preparing electrodes, utilizing the electrodes to carry out testing, setting up a standard curve and preparing and measuring samples.The modified electrode and the unmodified glassy carbon electrode are adopted to carry out the electrochemical reaction of the vitamin K1, it is found through comparison that the current response of the modified electrode to the vitamin K1 is far larger than that of the unmodified glassy carbon electrode, it shows that the response of nanometer titanium oxide to the vitamin K1 has a certain sensibilization effect, due to the porous structure of the nanometer titanium oxide membrane electrode, the specific area is increased, accordingly, the adsorption characteristic is enhanced, and more vitamin K1 can be enriched.According to the method of using the modified electrode to detect the vitamin K1 in serum, the serum does not need to be subjected to complex pretreatment, it only takes 100 s to detect each sample, detecting is convenient and fast, and the requirement for detecting a large number of the serum samples can be fully met.

The invention relates to a novel clinical application of minor radix buplenri granules. The invention further discloses an application of the minor radix buplenri granules or the minor radix buplenrigranules and amikacin in preparation of drugs for preventing and treating carbapenem-resistant klebsiella pneumoniae infection. It is found that the minor radix buplenri granules can be combined withthe amikacin in antibiotics to improve the antibacterial effect on CRKP, have the sensitization effect and can serve as a natural antibiotic sensitizer. The combined use of the minor radix buplenri granules and the amikacin can enhance the clinical treatment on the CRKP infection, and especially has good antibacterial effect and sensitization effect on bacterial pneumonia caused by the CRKP.

The invention discloses a high-performance powdery emulsion explosive for a three-level coal mine. The powdery emulsion explosive is prepared from components in parts by mass as follows: 70.0-80.0 parts of ammonium nitrate, 7.0-11.0 parts of sodium nitrate, 7.5-11.0 parts of water, 6.0-10.0 parts of sodium chloride, 1.2-1.5 parts of microcrystalline wax, 3.5-4.8 parts of hydrocarbon, 0.3-0.6 parts of a sensitizing agent and 2.0-2.5 parts of an emulsifier. The invention further relates to a preparation method of the high-performance powdery emulsion explosive for the three-level coal mine. The preparation method is simple and easy, the preparation cost is low, the prepared emulsion explosive is good in explosion performance and good in safety and produces little blasting fume, the explosive body is harder in form, non-sticky and high in water resistance, besides, index variation amplitude within the validity period is smaller, quality and stability of the emulsion explosive are improved, the quality guarantee period is prolonged, and the storage is stable.

The invention relates to a drug-resistant breast cancer drug screening method and an obtained effective treatment drug. The drug-resistant breast cancer drug screening method comprises the following steps that a drug-resistant breast cancer cell strain is selected, the resistance of the cell strain to an anti-breast cancer drug is confirmed, and a reference drug is selected; and the influence effect of a to-be-screened drug on cell apoptosis inhibition of a reference drug is detected, the influence on the glycolysis level of drug-resistant cells and the influence on mitochondria of the drug-resistant cells is detected, and the screened baicalein with excellent comprehensive evaluation is an effective anti-breast cancer drug sensitizer. The drug-resistant breast cancer drug screening method is especially suitable for obtaining a matched sensitizing drug aiming at a specific drug-resistant drug, so that precise medical treatment aiming at a specific drug-resistant breast cancer patient is facilitated.

The invention relates to a fluorescence detection method for bisphenol S content. The fluorescence detection method comprises the following steps: (1) preparing a series of bisphenol S solutions with different standard concentrations; (2) mixing the fluorescence sensitization system or the fluorescence quenching system with a series of bisphenol S solutions with different standard concentrations to form a reaction solution, reacting at room temperature, measuring the fluorescence intensity of the reaction solution by adopting a fluorescence method, and drawing by taking the concentration of the bisphenol S solution as a horizontal coordinate and the difference value of the fluorescence intensity as a vertical coordinate to obtain a bisphenol S standard curve, wherein the fluorescence sensitization system comprises an acid fuchsin solution, a hexadecyl trimethyl ammonium bromide solution and a borax solution, and a fluorescence quenching system comprises an acid fuchsin solution and a hexadecyl trimethyl ammonium bromide solution; and (3) mixing a to-be-detected sample with the fluorescence sensitization system or the fluorescence quenching system, reacting at room temperature, measuring the fluorescence intensity, and calculating the content of bisphenol S in the to-be-detected sample according to the bisphenol S standard curve. The detection system has the characteristics of normal temperature, simplicity, convenience, sensitivity and low detection limit.

The invention discloses an application of nano-selenium serving as a CIK (cytokine-induced killer) cell sensitizer. The application of the nano-selenium serving as the CIK cell sensitizer refers to applying the nano-selenium as the CIK cell sensitizer to assist CIK cells. The nano-selenium provided by the invention is at least one of pure nano-selenium, polyethylene glycol modified nano-selenium, polyvinylpyrrolidone modified nano-selenium, chitosan modified nano-selenium, polysaccharide modified nano-selenium, folic acid modified tumor-targeting nano-selenium and transferrin modified tumor-targeting nano-selenium; and the CIK cells are obtained by performing mononuclear cell separation on human peripheral blood, bone marrow or cord blood, and performing induced culture by using a CD-3 antibody and IFN-gamma and IL-2 in vitro. The nano-selenium sensitizer disclosed by the invention has low-price and easily-available raw materials, synthesis and purification steps are strong in operability, and the synthesis scale can be appropriately enlarged by virtue of process optimization, thereby achieving commercialization and application of the medicine.

The invention discloses a solanesol ramification of reductive sensibility of tumor tissue. The ramification structure is shown in the prediction. While serving as a micelle for carrying medicine, the solanesol ramification is characterized in that (1) the nano-scale grain size is smaller than 1000 nm, and the granulometric distribution is even and stable; (2) by means of the hydrophilic shell of polyethylene glycol and the nano-scale grain size, the long circulation of nano particles and passive targeting of EPR are achieved; (3) in the effect of the active targeting capable of reducing sensibility, the reductive material GSH which is richly contained in tumour cytoplasm can be utilized to achieve triggered-type drug release in tumor tissue portions; (4) the solanesol ramification has an excellent ability of loading hydrophobic anti-cancer drugs, a high drug loading capacity and great stability;(5) since the solanesol ramification has a great tumor targeting, medicine is more released in tumor tissue and less released in normal tissue, therefore the toxic and side effect performed on the normal tissue is decreased;(6) since the hydrophobic solanesol has an effect of inhibiting tumor cells and sensibilization of anti-cancer medicine, the inhibiting effect of tumor cells in anti-cancer medicine is enhanced.

The invention discloses a rock powder emulsion explosive for civilian use, which is made of the following raw materials in parts by weight: ammonium nitrate: 74-83%, calcium nitrate: 3.5-4%, oil phase: 3.2-3.5%, and composite emulsifier: 3-3.5%, urea: 2%, composite flame suppressant: 5-8%, porous granular ammonium nitrate: 0.5-3%, titanium hydride: 1-2%, mixed rare earth: 0.3%; the production process of the emulsion explosive In order to prepare water phase, oil phase, emulsification, add components to the emulsification matrix, negative pressure drying to make powder, add components to the powder and mix, and then make rock powder emulsion explosive. The composition and production process of the emulsion explosive of the invention can improve the detonation performance of the emulsion explosive, reduce the content of toxic gas, and produce a high-performance, safe rock powder emulsion explosive with little pollution.

A 1,1-dimethyl-3-propanesulfonindo-1'-(N, N-dimethylamino ethanamino)-3'-ethyl- imiazolyl-carbocyanine dye used as the optical spectrum sensitivity dye for the photographic emulsion is prepared through the condensation reaction between 1-(N, N-dimethylamino ethanamino)-2-methyl-3-ethyl imidazole iodine salt and 1,1-dimethyl-2-phenylaminovinyl-3-propanesulfono indole in the nitrobenzene under existance of triethylamine and acetic anhydride as condensating agent.

The technical scheme of the invention discloses an american ginseng orally disintegrating tablet as well as a preparation method and application thereof. The american ginseng orally disintegrating tablet comprises the following components of, in percentage by mass, 85%-95% of fresh american ginseng active freeze-dried powder and 5%-15% of cross-linked carboxymethyl flaxseed polysaccharide sodium. According to the technical scheme, the american ginseng orally disintegrating tablet can improve the utilization value of american ginseng, meanwhile, the american ginseng orally disintegrating tablet is convenient to take or eat so as to meet the requirements of specific people, and the american ginseng orally disintegrating tablet can be used for rehabilitation treatment after operations and radiotherapy and chemotherapy of pharyngolaryngeal cancer patients.

The invention relates to a cancer-resistant drug, which comprises alkaloid of kuh-seng andNotoginsen triterpenes at 1:0.1-1:10 mass ratio, wherein the invention combines Notoginsen triterpenes with alkaloid of kuh-seng to represent the functions as improve the general condition and eliminate the causative agents. Test has proved that it can significantly restrain cancer of mouse, improve drug effect, and reduce side effect. The invention has simple components and simple quality control.

The invention discloses a mixed indicator test paper for measuring ammonia concentration in air, a preparation method, and a detection method thereof, and belongs to the technical field of environmental monitoring and industrial hygiene. The test paper is loaded with bromocresol green, methyl red, acid, and nonionic surfactant on the base paper, and has a mass ratio of the bromocresol green: the methyl red: the acid: the non-ionic surfactant=(1.0-2.0): (0.188-0.75): (0.75-2.0): (2.5-7)x10<-3>. The preparation method comprises the following steps: preparing a soaking solution according to the mass ratio; soaking the base paper; and performing drying and encapsulating. The detection method comprises steps that the ammonia in the detection area air reacts with the mixed reagent of the test paper, and the color of the test paper is changed from claret to green; and the concentration of ammonia in the detection area air is obtained according to the relationship between the length of the color changing strip of the test paper and the ammonia concentration. The test paper has the advantages of being sensitive in reaction, high in precision, low in manufacturing cost, convenient to use, and the like, and has practicability and remarkable economic benefits.

The invention discloses an NK (Natural Killer) cell sensitizer prepared by combining functionalized nano-selenium with metformin and application of the NK cell sensitizer. Functional nano-selenium and metformin are combined to serve as an NK cell sensitizer to assist NK cells for application. The functionalized nano-selenium is at least one of independent nano-selenium, nano-selenium modified by polyacrylamide hydrochloride, nano-selenium modified by polyvinylpyrrolidone, nano-selenium modified by Tween 80, nano-selenium modified by polysaccharide, tumor targeting nano-selenium modified by folic acid and tumor targeting nano-selenium modified by transferrin; the NK cell is an NK-92 cell. The NK cell sensitizer can stimulate NK cells to secrete more cell factors so as to improve the anti-tumor effect of cell therapy, the raw materials of the obtained nano-selenium sensitizer are cheap and easy to obtain, the operability of synthesis and purification steps is high, the synthesis scale is properly expanded, and commercialization and application of drugs are achieved.

The invention discloses an improved method for detecting zinc through an atomic fluorescence spectrophotometer, and belongs to the field of analysis and detection. The method comprises the steps that a working curve of a zinc standard solution containing 2.5% hydrochloric acid and 0.20% potassium thiocyanate is prepared; a solution containing 0.7% potassium hydroxide, 3.0% potassium borohydride and 0.0025% 1, 10-phenanthroline is prepared as a reducing agent; a 2.5% hydrochloric acid solution is prepared as carrying current. The method is applicable to detecting zinc content through the atomic fluorescence spectrophotometer to replace a special analysis reagent provided by an instrument company, and the problem that the black precipitate phenomenon or memory phenomenon which is insoluble in hydrochloric acid is generated when an improving agent reacts with potassium borohydride is avoided. The method is simple, reliable and low in interference, and has the low detection limit and high accuracy.

The present invention relates to one kind of medicine composition including antisense thionucleotide 5'-CTC CCA GCG TGC GCC ATC-3' in the clinical dosage of 5-20 mg / kg and pharmaceutically acceptable carrier. In extracorporeal cultured human lung cancer cell line, the antisense thionucleotide with Bcl-2 protein mRNA as target point can inhibit the expression of the cancer causing gene bcl-2 effectively and specifically and make the cancer cell die in obvious early apoptosis effect. The animal model test shows that the antisense thionucleotide can inhibit the growth of tumor in human lung cancer induced nude mice obviously, with the inhibition rate in 20 mg / kg dosage reaching 90 %. The antisense thionucleotide and its medicine composition are suitable for use in preparing antitumor medicine.

The invention discloses a material based on natural diatom shells and phycobiliproteins and its application. The invention removes the organic matter contained in the shells of cultivated diatoms, and then utilizes APTES (3-aminopropyltrimethoxysilane) to make The silicon shell is alkylated, and then the alkylated silicon shell is reacted with the phycobiliprotein through BS3 (sulfosuccinimidyl suberate) to form a covalent connection to achieve the purpose of immobilizing the phycobiliprotein in the diatom shell . The diatom shell used is easy to obtain, relatively low in price and has high biocompatibility, stability, reaction inertia and certain light effect, so that the connected phycobiliprotein structure is more stable and has a sensitizing effect .