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An anti-tumor pharmaceutical composition

A technology of anti-tumor drugs and compositions, applied in drug combination, anti-tumor drugs, drug delivery and other directions, can solve problems such as toxic and side effects, and achieve the effects of reducing toxic and side effects, facilitating quality control, and improving drug efficacy

Inactive Publication Date: 2010-02-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The alkaloid components of Sophora flavescens have significant tumor growth inhibitory effects in vivo and in vitro, but have certain toxic and side effects at high doses

Method used

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  • An anti-tumor pharmaceutical composition
  • An anti-tumor pharmaceutical composition
  • An anti-tumor pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The notoginseng medicinal material is crushed to the size of soybeans to coarse powder, extracted with 20%-80% water-containing alcohol under heat reflux, recovered solvent, dissolved in water or dilute alcohol, and eluted with alkaline water, 30%, 70% ethanol through D101 macroporous resin , reclaim 70% ethanol eluate solvent, obtain Panax notoginseng total saponins. Adopt high performance liquid phase method (HPLC) to detect it, analysis condition is Agilent Extend-C18, mobile phase H 2 O-CH 3 CN, the detection wavelength is 203nm, respectively with notoginseng saponin R 1 , Ginsenoside Rg 1 , Ginsenoside Rb 1 , Ginsenoside Rd, and Ginsenoside Re are the detection components, and their contents are determined by the external standard method. The contents of the five components are respectively notoginsenoside R 1 6%, Ginsenoside Rg 1 42%, Ginsenoside Rb 1 23%, ginsenoside Rd 7%, ginsenoside Re 3%.

[0014] Grind the medicinal materials of Sophora flavescens, ...

Embodiment 2

[0016] Antitumor effect experiment of composition 1 (total saponins of notoginseng:total alkaloids of matrine=1:1.5)

[0017] The mice pre-inoculated with H22 ascites tumor were sacrificed, and 1ml of ascites tumor was extracted from the abdominal cavity, and diluted with normal saline to 2×10 5 cells / ml, injected into the underarm of ICR female mice at 0.2ml / only, and after 24 hours, they were randomly divided into groups and started to administer. The compositions were administered in high, medium and low doses respectively. After 8 days of continuous administration, the drug was stopped, the mice were weighed, and the tumor pieces were dissected and weighed separately for statistical analysis. See Table 1 for the results.

[0018] The experimental therapeutic effect of table 1 composition on mouse H22 liver cancer

[0019]

[0020] Compared with the control group, * P<0.05

Embodiment 3

[0022] Synergistic experiment of composition (total saponins of Panax notoginseng:total alkaloids of matrine=2:1) ​​and chemotherapeutic drugs

[0023] The mice pre-inoculated with H22 ascites tumor were sacrificed, and 1ml of ascites tumor was extracted from the abdominal cavity, and diluted with normal saline to 2×10 5 cells / ml, injected into the underarm of ICR female mice at 0.2ml / only, and after 24 hours, they were randomly divided into groups and started to administer. The dosage of the chemotherapeutic drug cyclophosphamide is 20 mg / Kg, intramuscular injection, and administered every other day; the dosage of cisplatin is 1 mg / Kg, intraperitoneal injection, and daily administration. The composition was intragastrically administered at a dose of 360 mg / Kg, once a day, and the results are shown in Table 2.

[0024] Table 2 Composition combined with chemotherapeutic drugs for experimental therapeutic effect on H22 liver cancer in mice

[0025]

[0026] Compared with th...

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Abstract

The invention relates to a cancer-resistant drug, which comprises alkaloid of kuh-seng andNotoginsen triterpenes at 1:0.1-1:10 mass ratio, wherein the invention combines Notoginsen triterpenes with alkaloid of kuh-seng to represent the functions as improve the general condition and eliminate the causative agents. Test has proved that it can significantly restrain cancer of mouse, improve drug effect, and reduce side effect. The invention has simple components and simple quality control.

Description

technical field [0001] The invention relates to an anti-tumor pharmaceutical composition, which contains matrine alkaloids and notoginseng saponin in a certain proportion, is mainly used for treating malignant tumors, and simultaneously has synergistic and attenuating effects on chemotherapeutic drugs. Background technique [0002] Surgical treatment, chemotherapy and radiotherapy are the main means of treating malignant tumors at present. When cancer patients receive radiotherapy and chemotherapy to kill tumor cells, they also cause great damage to the normal body. Such as inhibition of bone marrow hematopoietic function, gastrointestinal reactions, liver and kidney damage, and low immune function. Years of clinical practice have shown that the combination of traditional Chinese and Western medicine has a positive effect on the prevention and treatment of malignant tumors. Traditional Chinese medicine can relieve symptoms of patients, improve immune function and body condi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61K36/258A61K9/00A61P35/00
Inventor 程翼宇贺庆刘雳瞿海斌水文波
Owner ZHEJIANG UNIV
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