355results about How to "Overcome resistance" patented technology

The present invention relates to methods of typing a sample from an individual suffering from cancer. The invention further relates to methods for assigning treatment to an individual suffering from cancer, comprising typing a sample from an individual suffering from cancer according to the methods of the invention.

This invention contemplates a toothbrush construction which features a novel and unique assembly of parts comprising (1) an elongate handle end and (2) a disposable bristle containing end, said handle end serving as a reservoir storage place for music generating components; said disposable bristle containing end and handle end being constructed and arranged for end to end engagement and securement, said hollow handle serving as a reservoir / storage place for music generating components and having on its outer surface a solar panel for collecting energy suitable for powering the music generating components within, all to assist in the promotion of a healthy tooth brushing ritual.

The invention relates to an air purification material and a preparation method and application thereof, belonging to the technical field of chemical catalytic decomposition, in particular belonging to the technical field of decomposition of formaldehyde pollutants in environment air. The air purification material comprises a base material and manganese oxide, wherein the manganese oxide is supported on the base material, the base material is honeycomb ceramics or a fiber material with a particle filtering function, and the manganese oxide is birnessite manganese oxide prepared from permanganate and oxalate. The air purification material can effectively decompose formaldehyde pollutants in indoor air and can rapidly and constantly remove the formaldehyde pollutants in indoor air at room temperature. The air purification material can be regenerated through heating, so that the service life of the material is prolonged and the practical application is facilitated.

A check valve adapted to open only at a predetermined positive pressure, and to open fully and abruptly when said pressure is exerted.

The invention provides a method for hydrotreating high-sulfur and high-metal residual oil, which comprises the following steps: the residual oil and catalytic cracking recycle oil are in contact with a residual oil hydrogenation catalyst in the presence of hydrogen gas and under the hydrotreating reaction condition so as to carry out a hydrotreating reaction; the reaction product is separated to obtain gas, hydrogenated naphtha, hydrogenated diesel oil and hydrogenated residual oil. The residual oil hydrogenation catalyst is a combination of at least two catalysts, namely, an up-flow reactor catalyst and a fixed-bed hydrogenation catalyst and the two catalysts are respectively put in an up-flow reactor and a fixed-bed reactor; the ratio of the up-flow reactor catalyst and the fixed-bed hydrogenation catalyst is 30:70 to 70:30. The method can treat the high-sulfur and high-metal residual oil and effectively slow down the ascending speed of the pressure drop of the fixed-bed catalyst bed, thus realizing the long-term running of the device. Besides, the method can combine the residual oil hydrotreating and catalytic cracking more effectively and has better implementation effect.

A change of direction machine provides training for various muscles and body structures of a user. In one embodiment, the machine provides focused training for the muscles and body structures associated with making changes in the body's direction. The machine may comprise a pivoting arm assembly supported by a structure. The arm assembly may be configured to provide a resistance such that when a user engages the arm assembly a downward resistance may be applied to the user. The user may engage the arm assembly with his or her upper body and perform training or exercises involving lifting and lowering the user's body, moving laterally, or both. The machine may have various adjustable components to fit a user and to provide the desired resistance to the user.

ET-743 can be used to mitigate resistance to and potentiate the cytotoxic effects of a platinum coordination complex anti-neoplastic agent in a human cancer patient.

The invention pertains to a screwdriver bit with a drive section (14) and a front section (1) that contains a profiled penetrating section (2) and is manufactured by compression molding and subsequently sintering a hard metal powder, where the front section is connected to the drive section. Thus, according to the invention, the length of the front section (1) is not greater than 2.5-times the length of the penetrating section (2) and / or the ratio of the length of the front section (1) to the diameter or the width across corners of the penetrating section (2) is not greater than 2.2 (FIG. 7).

A change of direction machine provides training for various muscles and body structures of a user. In one embodiment, the machine provides focused training for the muscles and body structures associated with making changes in the body's direction. The machine may comprise a pivoting arm assembly supported by a structure. The arm assembly may be configured to provide a resistance such that when a user engages the arm assembly a downward resistance may be applied to the user. The user may engage the arm assembly with his or her upper body and perform training or exercises involving lifting and lowering the user's body, moving laterally, or both. The machine may have various adjustable components to fit a user and to provide the desired resistance to the user.

A system for modifying a shock wave formed in a fluid by a body to modify effects of the shock wave on information transferred to or from the body. The system includes means for heating fluid along a path to form a volume of heated fluid expanding outwardly from the path, the path extending from the body and through the shock wave; means for transferring the information to or from the body; and means for timing the transferring of the information relative to the heating of the fluid along the path to modify certain effects of the shock wave on the information.

A novel group of aminoglycosides which share some structural features of currently available aminoglycosides with regard to the backbone, while also having significant structural differences. The similarity enables these aminoglycosides to be highly potent and effective antibiotics, while the significant differences enable these aminoglycosides to reduce or even block antibiotic resistance.

A tool for telemedicine including an improved breath collection system of human breath to facilitate the analysis of volatile organic components (VOCs) contained in human breath in which breath tests can be performed at remote sites for rapid detection of different diseases. The system can include a standoff breath collection device including an arcuate structure for concentration and analysis of volatile organic components (VOCs) at the point-of-use that avoids the use of mouthpieces found in conventional breath collection apparatuses.

A shock wave in a gas is modified by emitting energy to form an extended path in the gas; heating gas along the path to form a volume of heated gas expanding outwardly from the path; and directing a path. The volume of heated gas passes through the shock wave and modifies the shock wave. This eliminates or reduces a pressure difference between gas on opposite sides of the shock wave. Electromagnetic, microwaves and / or electric discharge can be used to heat the gas along the path. This application has uses in reducing the drag on a body passing through the gas, noise reduction, controlling amount of gas into a propulsion system, and steering a body through the gas. An apparatus is also disclosed.

The invention discloses a high-efficiency continuous casting method of controllable structure-controllable closed cell foam aluminum ingot, belonging to the technical field of continuous porous metal preparation. According to the method, the decomposition control on a foaming agent in a melting body is realized by changing the treatment means of the foaming agent, the continuous production not only greatly improves the production efficiency but also solves the problem of bubble-free layers during static casting, and the continuous production of the closed cell foam aluminum ingot is achieved by controlling the casting temperature, the casting speed and the cooling intensity in a continuous casting process; the sizes and the shapes of bubbles in an aluminum substrate are controlled by adding foaming agents which have different types, different additive amounts and different particle sizes and are subjected to different pretreatments, and a control method of the porous structure is relatively high in realizability and relatively meets the requirements on the product diversity in actual application. The method is simple in process and low in cost, achieves the continuous casting, greatly improves the production efficiency, relatively meets the industrialized requirements and can be used for efficiently and continuously preparing large-sized closed cell foam aluminum ingot.

The invention provides a magnetic mesoporous silica gel material extracting agent used for enriching and / or separating trace organic pollutants in an environment water sample, and a preparation method thereof. A core of the extracting agent provided by the invention is a silicon gel microsphere (i.e. magnetic silicon gel microsphere) wrapped with a plurality of Fe3O4 magnetic nano particles, and a shell of the extracting agent is a mesoporous silicon gel shell layer with inner and outer surfaces modified by C18 silanization. The extracting agent integrates huge special surface area, excellent extracting capacity and ultrahigh extracting volume of a mesoporous material, magnetic separating capacity of a magnetic material, strong extracting capacity of C18 groups and special volume exclusion function of a vertical channel of the mesoporous material. In addition, the extracting agent provided by the invention has the advantages of high extracting efficiency, low preparation cost and simple preparation method, and is very suitable for preprocessing samples of the trace organic pollutants in a bulk-mass water sample.

The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

A system for modifying a shock wave formed in a fluid by a body to modify effects of the shock wave on an object released from the body including heating fluid along a path to form a volume of heated fluid expanding outwardly from the path, the path extending from the body and through the shock wave, releasing the object from the body, and timing a release of the object relative to the heating of the fluid along the path to modify certain effects of the shock wave on the object.

A system for modifying a shock wave formed in a fluid by a body to modify effects of the shock wave on information transferred to or from the body. The system includes an element for heating fluid along a path to form a volume of heated fluid expanding outwardly from the path, the path extending from the body and through the shock wave; mechanism for transferring the information to or from the body; and device for timing the transferring of the information relative to the heating of the fluid along the path to modify certain effects of the shock wave on the information.

A change of direction machine provides training for various muscles and body structures of a user. In one embodiment, the machine provides focused training for the muscles and body structures associated with making changes in the body's direction. The machine may comprise a pivoting arm assembly supported by a structure. The arm assembly may be configured to provide a resistance such that when a user engages the arm assembly a downward resistance may be applied to the user. The user may engage the arm assembly with his or her upper body and perform training or exercises involving lifting and lowering the user's body, moving laterally, or both. The machine may have various adjustable components to fit a user and to provide the desired resistance to the user.

A shock wave in a gas is modified by emitting energy to form an extended path in the gas; heating gas along the path to form a volume of heated gas expanding outwardly from the path; and directing a path. The volume of heated gas passes through the shock wave and modifies the shock wave. This eliminates or reduces a pressure difference between gas on opposite sides of the shock wave. Electromagnetic, microwaves and / or electric discharge can be used to heat the gas along the path. This application has uses in reducing the drag on a body passing through the gas, noise reduction, controlling amount of gas into a propulsion system, and steering a body through the gas. An apparatus is also disclosed.

There is provided an airless paint spray pump wherein the pump is a double acting piston pump having an inlet communicating with a source of paint, a motor for driving the pump, a pressure controller for controlling the pressure of the pressurized paint delivered by the pump, and a filter for filtering the paint delivered by the pump. The pump includes features which increase the accessibility of the components thereof, prevent the incorrect installation of the seal packings in the pump cylinder, and allow the assembly of the piston in the pump cylinder properly aligned with the cylinder so as not to damage the seal packings therein.

Described herein are combination therapies for cancer (such as lymphoid malignancies) and immune diseases (such as autoimmune diseases and inflammatory diseases). The therapies comprise the combined use of inhibitors of BTK, mTOR kinase, and Bcl-2 or their signaling pathways, and immunomodulatory drugs. Also described are pharmaceutical compositions and kits comprising these inhibitors.

A stabilizing and vibration-isolating mount to facilitate the manual operation of a camera from mobile platforms such as aircraft, motor vehicles, and watercraft. The camera mount comprises a carriage assembly that allows the roll axis of rotation to pass through the optical axis of the camera lens, thus eliminating the pendulum or over-the-center phenomenon that characterizes moving images filmed while the camera is moving about the roll axis. Movement around all three axes of rotation can be stabilized by gyrostabilizers that can be adjustably positioned through the centerlines of the pan, roll, and tilt axes.

Robotic customer service agents are provided such that, when properly authenticated, they are operable to perform a customer service task. A contact center may dispatch a robot, an accessory for a customer-owned robot, or instructions to transform an unconfigured robot, such as a generic robot, into a configured robot operable to perform the task. If the robot, such as the base or entire robot, robot at the service location, an associated user, hardware addition, and / or software addition is authentic, then the robot may be operated in an authenticated mode. If non-authenticated, then the robot may operate in a non-authenticated mode, such as one consisting of one or more tasks or features being disabled. Additionally, authentication may be temporary (e.g., time restricted) or event restricted (e.g., as long as a result stays within a given range, the robot is being observed, etc.).

A rifle chamber cleaning tool comprising a single piece of material with an annular scraping head and a plurality of elongated fingers, comprising debris capturing chambers within the elongated fingers. The scraping head and fingers are shaped so as to fit snugly when inserted between the lug recesses inside the rifle chamber. The distance between the fingers is roughly equivalent to the distance between the locking lugs inside the rifle chamber.

An eyewear assembly for attachment to headwear such as a sun hat, the headwear including a main body and a visor, the eyewear assembly including at least one eyewear member, at least one mounting means to attach the set of eyewear to the headwear and a pair of rotation mechanisms associated with the mounting means and the eyewear to movement relative to the at least one mounting means between a use position in front of a wearer's eyes and a stored position adjacent the visor of the headwear.