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Electrochemical blood detection method and device for reducing red blood cell interference

A blood detection and electrochemical technology, applied in the field of electrochemical detection, can solve problems such as affecting measurement results, and achieve the effects of accurate measurement results, guaranteed accuracy, and simple structure

Pending Publication Date: 2017-12-05
WUHAN J H BIO TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to overcome the problem that the measurement results of the existing electrochemical detection methods are affected by red blood cells, and provide an electrochemical blood detection method and device that reduces the interference of red blood cells, which has the characteristics of eliminating the influence of red blood cells on the measurement results

Method used

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  • Electrochemical blood detection method and device for reducing red blood cell interference
  • Electrochemical blood detection method and device for reducing red blood cell interference
  • Electrochemical blood detection method and device for reducing red blood cell interference

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Embodiment 1

[0030] Such as Figure 2-4 As shown, this embodiment provides an electrochemical blood detection device applying the above-mentioned electrochemical blood detection method for reducing red blood cell interference, and the device includes a blood glucose test strip.

[0031] The blood glucose test paper comprises a substrate layer 1, a siphon opening 2 arranged at one end of the substrate layer 1, an enzyme layer 3 embedded on the substrate layer 1, and electrodes 4 arranged on both sides of the enzyme layer 3; The layer 3 is connected, and the opposite side or side of the enzyme layer 3 is provided with a magnetic layer 5; the blood glucose test paper also includes anti-erythrocyte antibody magnetic beads 9 which are attracted and matched with the magnetic layer 5, and the anti-erythrocyte antibody magnetic beads 9 are arranged on the enzyme layer 3 or The anti-erythrocyte antibody magnetic beads 9 are magnetic beads coupled with the anti-erythrocyte antibody 8 .

[0032] Aft...

Embodiment 2

[0036] Such as Figure 5 As shown, the electrochemical blood detection device in this embodiment is a blood glucose test strip and a blood glucose detector 11 matched therewith (the part shown in the figure is a part of the blood glucose detector, not all of the blood glucose detector); the blood glucose test strip includes a substrate layer 1, The siphon port 2 located at one end of the substrate layer 1, the enzyme layer 3 embedded on the substrate layer 1 and the electrodes 4 located on both sides of the enzyme layer 3; the siphon port 2 communicates with the enzyme layer 3, and the enzyme layer 3 is provided with There are anti-erythrocyte antibody magnetic beads 9, and the anti-erythrocyte antibody magnetic beads 9 are magnetic beads coupled with anti-erythrocyte antibody 8; in the blood glucose detector 11, there is a position on the opposite side or side of the enzyme layer 3 corresponding to the blood glucose test paper. The magnetic substance 10 of the erythrocyte ant...

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Abstract

The invention discloses an electrochemical blood detection method and device for reducing blood red cell interference, and the method comprises the following steps: blood and anti red cell antibody beads are reacted, blood red cells are bonded with the anti red cell antibody beads to obtain red cell beads; the anti red cell antibody beads are anti red cell antibodies combined with nano magnetic beads; 2) the blood red cell beads are absorbed by a magnetic material to exclude the blood red cell interference in subsequent blood electrochemical detection process; and 3) magnetic material adsorption blood is routinely electrochemically detected. The device is an electrochemical biosensor test paper or / and an electrochemical detector. The beneficial effects are that through the detection method, during electrochemical blood detection, the influence of large volume of red blood cells on the measurement is eliminated, and the accuracy of detection results is ensured.

Description

technical field [0001] The invention relates to the technical field of electrochemical detection, in particular to an electrochemical blood detection method and device for reducing red blood cell interference. Background technique [0002] The electrochemical biosensor test paper currently on the market generally adopts an electrochemical method, such as a blood sugar test paper, which is converted into a monitoring of the blood sugar concentration by enzymatically catalyzing the current measurement generated by glucose. However, the electrochemical detection methods currently on the market (such as figure 1 The shown electrochemical biosensor test paper) has hardly considered the influence of red blood cells on the measurement results, that is, the larger red blood cells will affect the measurement current, and then affect the measurement results, and the current electrochemical detection method cannot eliminate this phenomenon. influences. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N33/543
CPCG01N27/3272G01N33/54333G01N2446/90
Inventor 周军曾生王健斌龚贻洲
Owner WUHAN J H BIO TECH
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