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Prunella spike extract and its preparation method and use

An extract, Prunella vulgaris technology, applied in the field of Chinese herbal medicine extracts, can solve the problem of not proposing new uses of the extract, and achieve the effect of enhancing the immunosuppressive effect

Active Publication Date: 2005-01-05
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the prior art, no other new extracts and their new uses have been proposed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1. An extract of Prunella vulgaris, the total phenolic acid content of the active components of the extract is 70%, and the content of rosmarinic acid is 21%.

Embodiment 2

[0017] Example 2. A preparation method of Prunella vulgaris extract, taking Prunella vulgaris medicinal material, extracting 60% ethanol with 6, 8, and 10 times the amount of medicinal material respectively under reflux for 3 times, each time for 2 hours, filtering, merging the ethanol extracts, and recovering ethanol to No alcohol smell, concentrated to a relative density of 1.10, refrigerated for 24 hours, poured out the supernatant, added alcohol until the alcohol content reached 65%, added concentrated ammonia water to make the pH equal to 8, recovered ethanol, added 10% of the concentrated solution Adjust the pH to 3 with HCL, extract 6 times with ethyl acetate, the amount of each time is 3 times that of the concentrated solution, recover the ethyl acetate to a thick paste with a density of 1.35, dry it in vacuum, and pulverize it.

Embodiment 3

[0018] Example 3. An extract of Prunella vulgaris, the total phenolic acid content of the active components of the extract is 65%, and the content of rosmarinic acid is 18%. Its preparation method is to take the medicinal material of Prunella vulgaris, reflux extraction with 40% ethanol of 4, 5, 6, and 7 times the amount of the medicinal material, respectively, for 4 times, each time for 1 hour, filter, combine the alcohol extracts, and recover the ethanol until it has no alcohol smell. , concentrated to a relative density of 1.0, refrigerated for 12 hours, poured out the supernatant, added alcohol until the alcohol content reached 60%, added concentrated ammonia water to make the pH equal to 8, recovered ethanol, added 5% HCL to the concentrated solution to adjust the pH 4, extracted 5 times with ethyl acetate, the amount of each time was 4 times that of the concentrated solution, recovered ethyl acetate to a thick paste with a density of 1.30, vacuum dried, and pulverized. ...

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Abstract

An extract of prunella spike for treating rheumatoid arthritis and improving immune suppression contains phenolic acid (60-70%) and rosemaric acid (14-21%). Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a Chinese herbal medicine extract, in particular to a Prunella vulgaris extract; the invention also relates to a preparation method and application of the extract. Background technique [0002] Prunella vulgaris was first recorded in "Shen Nong's Materia Medica", and it is one of the most commonly used Chinese medicinal materials. It is now recorded in the 2000 edition of "Chinese Pharmacopoeia", and it is the dried ear of Prunella vulgaris L. It has the effects of clearing fire, improving eyesight, dispelling stagnation, and reducing swelling. Hypoglycemic element in Prunella vulgaris is one of the effective components of hypoglycemic effect, and its hypoglycemic mechanism is to repair islet cells and make insulin secretion normal, so as to achieve the purpose of treatment. In the experiment on the effect of alcohol extract on blood sugar in mice, it was found that the extract can resist the effect of ad...

Claims

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Application Information

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IPC IPC(8): A61P19/02A61P29/00
Inventor 肖伟陈艳平王振中廖正根
Owner JIANGSU KANION PHARMA CO LTD
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