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Salvianolic acid A preparing process

A technology of salvianolic acid and salvianolic acid, applied in the field of preparation of salvianolic acid A, can solve the problem of industrial production of salvianolic acid A, low yield of salvianolic acid A and high production cost. problems, to achieve the effect of cost reduction, improvement of curative effect and stable quality

Inactive Publication Date: 2007-01-03
CHIATAI QINGCHUNBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Because the content of salvianolic acid A in medicinal materials is low or even absent, the yield of salvianolic acid A is low, the production cost is high, and there are certain limitations in large-scale industrial production. In fact, it cannot fundamentally solve the problem of salvianolic acid A. industrial production problems

Method used

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  • Salvianolic acid A preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment one: the preparation method of salvianolic acid A, its processing step is:

[0032] 1. Water extraction (warm immersion method): Add 8 times the amount of red sage powder to warm immersion at 80°C for 3 times, each time for 1.0 hour, and filter.

[0033] 2. Purification of salvianolic acid A by column chromatography: centrifuge the combined filtrates (4000 rpm) for 10 minutes, take the supernatant and pass it through a 1400 macroporous adsorption resin column, wash with water until the sugar detection reaction is negative, and then use 20% ethanol Eluted to FeCl 3 If the reaction is negative, change to 40% ethanol to elute to FeCl 3 The reaction was negative, and the eluate was collected and concentrated under reduced pressure at 60°C until there was no alcohol smell.

[0034] 3. Adjust the pH value and extract with organic solvent: add hydrochloric acid to adjust the pH value to 3-5, extract 4 times with ethyl acetate of 1.5 times the volume of the drug so...

Embodiment 2

[0036] Embodiment two: basically the same as embodiment one, the difference is that the extraction process is reflux extraction of 60% ethanol aqueous solution. The specific method is as follows:

[0037] Salvia miltiorrhiza coarse powder, add 10 times the amount of 60% ethanol to reflux and extract 3 times, each time for 1.5 hours, and filter.

Embodiment 3

[0038] Embodiment 3: basically the same as Embodiment 1, the difference is that the solid impurities are preliminarily removed by filtration after the extract is reacted.

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Abstract

The present invention discloses one salvianolic acid A preparing process. The salvianolic acid A preparing process includes extract red sage material with water or alcohol, concentrating the extracted liquid, purifying salvianolic acid A in chromatographic column, extracting with organic solvent in regulated pH value, concentrating and drying to obtain salvianolic acid A. The said process has high salvianolic acid A extracting rate, and high salvianolic acid A product purity, up to 90 %, stable quality, and is suitable for large scale production.

Description

technical field [0001] The present invention relates to a kind of preparation method of salvianolic acid A, the structure of salvianolic acid A is as follows: [0002] technical background [0003] Danshen is one of the most commonly used medicinal materials for the treatment of cardiovascular and cerebrovascular diseases such as angina pectoris, hypertension, coronary heart disease and stroke. However, the crude extract extracted from Salvia miltiorrhiza or directly used in slices of Danshen is generally used. In the past two decades, salvianolic acid compounds, the main active components of Danshen, have been discovered one after another. The results of in vitro experiments show that salvianolic acid compounds can not only treat cardiovascular and cerebrovascular diseases, but also treat various diseases, such as liver disease, kidney disease, peptic ulcer, tumor and so on. Salvianolic acid B has the highest content among the total phenolic acids of salvia miltiorrhiz...

Claims

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Application Information

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IPC IPC(8): C07C69/732A61K36/53A61K125/00
Inventor 黎豫杭柴建国张善飞潘迎锋张建兵
Owner CHIATAI QINGCHUNBAO PHARMA
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