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Application of salvianolic acid A composition for preparing medicines for preventing and/or treating cerebral thrombosis

A technology of salvianolic acid and composition, which is applied in the field of preparation of drugs for preventing and or treating cerebral thrombosis, can solve the problems of low natural content of salvianolic acid A, neglect, and difficulty in separation and purification, and achieves saving production cycle, saving cost, The effect of increasing conversion rates

Active Publication Date: 2013-05-08
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the use of existing preparations related to cardiovascular and cerebrovascular diseases blindly pursues to increase the purity or content of salvianolic acid A in the preparation, while ignoring the attempt to explore whether the combination of salvianolic acid A and other related ingredients can achieve the same or even better effect
[0008] However, the natural content of salvianolic acid A is extremely low (about 0.01-0.06% of the salvia miltiorrhiza), which makes the cost of the original medicinal material too high, and the separation and purification are too difficult, which restricts the development and research of the drug and becomes the bottleneck of its industrialization

Method used

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  • Application of salvianolic acid A composition for preparing medicines for preventing and/or treating cerebral thrombosis
  • Application of salvianolic acid A composition for preparing medicines for preventing and/or treating cerebral thrombosis
  • Application of salvianolic acid A composition for preparing medicines for preventing and/or treating cerebral thrombosis

Examples

Experimental program
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Effect test

Embodiment 1

[0110] Take Danshen medicinal material, crush it into 6-mesh granules, add 7 times the amount of 92°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, and warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to relative Density 1.20 (60°C), add ethanol to make the alcohol content at 70%, let it stand, filter, the filtrate is decompressed to recover ethanol and concentrate until it has no alcohol smell; add water to dilute to contain salvianolic acid B20mg per 1ml, use 10% for aqueous solution Adjust the pH to 4.0 with sodium hydroxide, add 0.5% ZnCl 2As a catalyst, heat and transform at 120°C for 4 hours, adjust the pH value of the transformation liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and perform HPD-100 macroporous resin column chromatography For separation, the ratio of salvianolic acid A load...

Embodiment 2

[0113] Take Salvia miltiorrhiza, cut into decoction pieces, add 8 times the amount each time, soak in water at 90°C for 3 times, and stir at a speed of 20 rpm, and extract with warm soaking for 2.5 hours each time; the extract is concentrated under reduced pressure to a relative density of 1.10 (60 ℃), add ethanol to make the alcohol content at 75%, let it stand, filter, and the filtrate reclaims ethanol under reduced pressure and concentrates to no alcohol smell; add water to dilute to contain salvianolic acid B15mg per 1ml, adjust the aqueous solution with 10% potassium hydroxide pH to 5.0, add 0.6% FeCl3 as a catalyst, transform by heating at 120°C for 3.5 hours, adjust the pH value of the transformation solution to 2.5 with 15% hydrochloric acid, centrifuge, and concentrate the supernatant under reduced pressure to contain 5 mg of salvianolic acid A per 1 ml. HPD-100 macroporous resin column chromatography separation, the ratio of salvianolic acid A loading to macroporous a...

Embodiment 3

[0116] Take Danshen medicinal material, crush it into 4-mesh to 10-mesh granules, add 9 times the amount each time, soak in water at 85°C for 2 times, and stir at a speed of 30 rpm, and extract with warm soaking for 3.5 hours each time; the extract is concentrated under reduced pressure to Relative density 1.18 (60°C), add ethanol to make the alcohol content 75%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates until there is no alcohol smell; add water to dilute to contain salvianolic acid B18mg per 1ml, and use 10 mg of salvianolic acid B in the aqueous solution % sodium carbonate to adjust the pH to 5.2, add 0.6% AlCl3 as a catalyst, convert by heating at 123°C for 4.5 hours, adjust the pH of the conversion solution to 2.8 with 15% nitric acid, centrifuge, and concentrate the supernatant under reduced pressure to contain salvianol per 1ml Salvianolic acid A6mg, separated by HPD-100B macroporous resin column chromatography, the ratio...

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Abstract

The invention relates to application of a salvianolic acid A composition for preparing medicines for preventing and / or treating cerebral thrombosis. The composition is prepared from the following components in percentage by weight: 90-99% of salvianolic acid A, 0.1-3% of alkannic acid, 0.1-3% of rosmarinic acid, 0.1-3% of salvianolic acid B and 0.1-5% of salvianolic acid C.

Description

technical field [0001] The invention relates to the use of a salvianolic acid A composition for preparing a medicine for preventing and or treating cerebral thrombosis. technical background [0002] Cerebrovascular disease, also known as stroke, is a neurological disease caused by various causes of blood vessels supplying the brain. The main cause is cerebral arterial lumen stenosis, vasospasm, occlusion or rupture, reduced or complete blockage of blood flow, brain blood circulation and dysfunction caused by cerebral arterial system damage (such as cerebral arteriosclerosis), and brain tissue damage. A series of symptoms caused by damage. Mainly including ischemic and hemorrhagic cerebrovascular diseases. Among them (ICVD, also known as ischemic stroke) accounted for about 80%. [0003] Ischemic cerebrovascular disease refers to the degeneration, necrosis or transient loss of function of local brain tissue including nerve cells, glial cells and connecting fibers due to bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61K31/216A61K36/537A61P7/02A61P9/10
Inventor 程帆张功俊杨小玲蔡元魁李志勇欧阳婷
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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