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Biodegradable medical polymer tubing and preparation method thereof

A technology of biodegradable and polymer materials, which is applied in the field of biodegradable medical polymer tubing and its preparation, can solve the problems of processing high-precision tubing from refractory biodegradable polymers, and achieve cost-saving, simple operation, and cost-saving energy effect

Active Publication Date: 2013-03-27
杨立群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional polymer processing methods are largely difficult to process biodegradable polymers into high-precision tubing that can meet clinical requirements

Method used

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  • Biodegradable medical polymer tubing and preparation method thereof
  • Biodegradable medical polymer tubing and preparation method thereof
  • Biodegradable medical polymer tubing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Assemble a PTFE core with an outer diameter of 2 mm and a PTFE shell with an inner diameter of 3 mm concentrically and coaxially, place it in the reactor, add 0.1 mol of trimethylene carbonate at the same time, and vacuumize for 3 Stannous octoate was added as a catalyst after the first time, and the molar ratio of trimethylene carbonate and catalyst was 1000:1, and the vacuum was evacuated for 3 times (vacuum degree <15Pa), the tube was sealed under vacuum conditions, and the bulk polymerization reaction was carried out at 130 ° C for 24h After taking out, cooling and demoulding can obtain a polytrimethylene carbonate pipe with an inner diameter of 2 mm and a wall thickness of 0.5 mm.

Embodiment 2

[0042] After the stainless steel mold core with an outer diameter of 3mm and a stainless steel shell with an inner diameter of 5mm were treated with fluorine release agent, they were assembled together concentrically and placed in the reactor, and 0.1mol of caprolactone was added at the same time. After vacuuming for 3 times, add stannous octoate as a catalyst, the molar ratio of caprolactone to catalyst is 3000:1, vacuumize for 3 times (vacuum degree <15Pa), and seal the tube under vacuum conditions. After 48 hours of bulk polymerization at 150°C, take it out, cool and demould to obtain a polycaprolactone pipe with an inner diameter of 3 mm and a wall thickness of 1 mm.

Embodiment 3

[0044] After silanization of a glass mold core with an outer diameter of 5 mm and a glass shell with an inner diameter of 10 mm, they were assembled together concentrically and placed in the reactor, and 0.3 mol of trimethylene carbonate and 0.7 mol of caprolactone were added at the same time. And 0.001mol of crosslinking agent 5,5'-(propane-diyl)dioxepane-2-one, add stannous octoate as catalyst after vacuuming for 3 times, adding amount is 0.0002mol, decompression Vacuum 3 times (vacuum degree <15Pa), and seal the tube under vacuum conditions. After 36 hours of bulk polymerization at 110°C, take it out, cool and demould to obtain a trimethylene carbonate and caprolactone cross-linked copolymer pipe with an inner diameter of 5 mm, a wall thickness of 2.5 mm and a cross-link density of 0.2%. According to the preparation method of Example 3, adjusting the copolymerization ratio of TMC and CL and the usage amount of the cross-linking agent BTB, the trimethylene carbonate and capr...

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Abstract

The invention relates to a biodegradable medical polymer tubing and a preparation method thereof. The invention provides a biodegradable medical polymer tubing with adjustable diameter and controllable wall thickness and a preparation method thereof. The tubing is made from biodegradable medical polymer material, and has inner diameter of 0.5-20 mm and thickness of 0.05-10 mm; and the biodegradable medical polymer material is one of a homopolymer, a copolymer, a star-shaped polymer and a crosslinking polymer of trimethylene carbonate, p-dioxanone, lactide, caprolactone and glycollide.

Description

Technical field: [0001] The invention belongs to the technical field of polymer materials and the field of biomedical engineering, and more particularly relates to a biodegradable medical polymer pipe material and a preparation method thereof. Background technique: [0002] Biodegradable medical polymer tubing has good biodegradability and excellent biocompatibility, and can be degraded into small molecular compounds in the body and metabolized, absorbed or excreted by the body. In clinical applications such as release systems and tissue engineering scaffolds, there is no need for secondary surgery, which can alleviate the pain of patients, simplify the surgical procedure, improve the treatment effect, prolong the life of the patient, and improve the quality of life of the patient. Therefore, biodegradable medical polymer pipes have been more and more widely used in the field of biomedicine, and have effectively promoted the development of biomedicine and clinical medicine. ...

Claims

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Application Information

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IPC IPC(8): A61L29/06A61L27/18A61L31/06
Inventor 杨立群顾忠伟李建新关艳敏孟舒
Owner 杨立群
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