45results about How to "Removal without secondary surgery" patented technology

The invention relates to a method for producing a water-absorbing swellable carboxymethyl chitosan sponge and its application, which comprises: adding a little chitosan powder or chitosan powder into the carboxymethyl chitosan solution with a quantitation of glycerin as the elasticizer, making every 100 ml solution with carboxymethyl chitosan of 1-5 g, chitosan powder or chitosan powder of 0.5-2 g and glycer of 1-5 g, stirring to foam and adding the environment-friendly ion-cross linker to cross-linking completely, cooling and drying to get the production. In the invention, using water-soluble materials as raw materials to avoid contamination, and using non-aldehyde group ion-cross linker to avoid residual toxicity of aldehyde group.

The invention relates to a 3D-printed porous tantalum metal bone plate. The 3D-printed porous tantalum metal bone plate is characterized in that tantalum metal powder is taken as a base material, andthe bone-imitating trabecular bone plate having bone induction property and produced by 3D printing has an interconnecting-pore structure fit for bone growth. The production method includes: under argon production, using medical grade spherical tantalum powder as a raw material to produce the porous bone plate by 3D printing; removing excess metal powder adhering to the surface of the bone plate through sandblasting; removing residual stress through heat treatment to make the surface of the bone plate smooth. By the arrangement, the porous bone plate with the bone induction property can form excellent bone integration with bone tissue so as to achieve permanent fixation in biology.

The invention provides a medical implanted degradable composite bar and a preparing method thereof. The medical implanted degradable composite bar is characterized in that the innermost layer is a magnesium alloy, the middle layer is a zinc alloy, the zinc alloy and the magnesium alloy are connected in the form of a dovetail groove, the liquid zinc alloy is poured around the solid magnesium alloyat the high temperature, so that the magnesium alloy and the zinc alloy are in metallurgical bonding, and the outermost layer is a biological coating. The magnesium alloy comprises chemical componentsincluding, by mass percent, 8%-15% of CaO, 3%-10% of Zn, 2%-8% of Sr, 0.8%-2% of Ce and the balance Mg. The zinc alloy comprises chemical components including, by mass percent, 0.1%-1.0% of Mg, 0.5%-2.0% of Mn, 0.05%-0.6% of Sr, 0.1%-0.5% of Sn, 0.08%-0.6% of La and the balance Zn. The biological coating comprises chemical components including, by mass percent, 50%-65% of nano beta-Ca3(PO4)2 andnano CaCO3 composite particles, 3%-8% of nano silver particles and the balance polylactic acid, wherein the mass ratio of nano beta-Ca3(PO4)2 to nano CaCO3 is 1:2. The composite bar has good mechanical performance, the medical requirements can be met, integral materials can be completely degraded, and taking-out through the second operation is not needed.

The invention belongs to the technical fields of macromolecule materials and biomedical engineering, in particular to a method for constructing a composite structure tissue engineering bracket containing different extracellular matrixes. The method comprises the following steps: preparing a blood vessel bracket by an electrostatic spinning method; preparing a poriferous bracket part by adopting a blend of polylactic acid and polycaprolactone through a hot-pressing and salting-out method; and introducing the blood vessel bracket into the poriferous bracket. The composite structure tissue engineering bracket constructed in the invention realizes that different extracellular matrixes are constructed in a same bracket.

The invention relates to a drug-carrying nanocomposite fiber membrane system and a preparation method and application thereof. The drug-carrying nanocomposite fiber membrane system comprises a first nanofiber layer, a second nanofiber layer and a third nanofiber layer; the first nanofiber layer includes a polylactic acid-hydroxyacetic acid copolymer, polydioxanone and drugs; the second nanofiber layer includes a polylactic acid-hydroxyacetic acid copolymer, polyglycolic acid and drugs; the third nanofiber layer includes polylactic acid-hydroxyacetic acid copolymer, polyethylene glycol and drugs. The preparation method includes: respectively dissolving and mixing polymer materials and drugs contained in the nanofiber layers to obtain three kinds of mixed solutions; subjecting the mixed solutions to electrostatic spinning in sequence to obtain the drug-carrying nanocoposite fiber membrane system. The drug-carrying nanocomposite fiber membrane system is a complete 0-day to 2.5-month drugsustained release system, achieving multi-gradient, multi-stage and long-term drug release.

The invention discloses a degradable pure magnesium metal bone fracture plate for limb long bone fracture fixation, comprising a long strip shaped bone fracture plate body and through holes disposed in the bone fracture plate body. The through holes comprise threaded round locking holes and long strip shaped compressive holes. The compressive holes are positioned at the center of the body. The locking holes are symmetrically distributed at two sides of the compressive holes. An upper surface of the bone fracture plate body is provided with a reinforcing rib projection. The locking holes and the compressive holes are positioned at an inner side of the reinforcing rib projection. Two sides of the bone fracture plate body are fixedly connected with outwardly projecting side arms respectively, and each side arm is provided with screw fixing holes. The upper surface of the bone fracture plate body is provided with a loop of reinforcing rib projection, biomechanical property of degradable magnesium metal is enhanced, and the bone fracture plate body can be prevented from being fractured. The two sides of the bone fracture plate body are provided with the surrounding type side arms and the fixing screw holes, the bone fracture plate can be well attached to a bone surface, the compressive effect is achieved, and the fracture position can be well controlled and fixed.

The invention discloses a medical degradable magnesium-zinc-magnesium composite bar with osteoinductive activity, and a preparation method thereof. The innermost layer is a wrought magnesium alloy layer, the middle layer is a zinc alloy layer, the outer layer is a cast magnesium alloy layer, the zinc alloy layer and the cast magnesium alloy layer are connected in the form of dovetail grooves and dovetail protruding edges, protrusions and grooves are formed in the dovetail protruding edges at intervals in the length direction of the bar, the dovetail grooves are communicated in the length direction of the bar, the separation phenomenon between different layers in the length direction of the bar is avoided, liquid alloy is poured around the bar at the solid state and the high temperature ofthe alloy to enable the bar to be metallurgically bonded, and the bonding strength is high. Round holes are formed in the cast magnesium alloy layer, and biological filling layers are arranged in theround holes and cannot fall off when implanted into a human body. The whole material can be completely degraded and does not need to be taken out through a secondary operation. The invention further provides a preparation method of the medical degradable magnesium-zinc-magnesium composite bar with osteoinductive activity. The preparation method has the characteristics of convenience in operation and easiness in industrial production.

The invention relates to a polylactic-acid-modified magnesium alloy medical composite material and a preparation method thereof. The method comprises: 1) performing micro arc oxidation treatment on a surface of a magnesium alloy substrate, and performing coupling treatment to obtain a silicane coupling substrate; 2) adding a surfactant to a chitosan solution, and performing uniform mixing to obtain a chitosan mixed liquid, and dissolving polylactic acid in trichloromethane to prepare a polylactic acid solution, and adding the polylactic acid solution in the chitosan mixed liquid while performing stirring, and performing high speed emulsification to obtain a film-casting liquid; and 3) coating the surface of the silicane coupling substrate with the film-casting liquid, removing the solvent and the surfactant to obtain a dry film layer, and performing thermal insulation at 80-90 DEG C to obtain the composite material. The composite material is excellent in biological compatibility, surface activity and mechanical properties. The degradation rate of the material can be controlled by adjusting the thickness of a polylactic acid and chitosan film layer. After the material is implanted to a human body, the degradation product can be absorbed by the human body or excreted outside the body with metabolism, so that secondary operation is not required.

The invention discloses a bionic bone joint based on curved surface 3D printing and a preparation method thereof. The multilayer bionic joint is formed by an inner layer, a middle layer and an outer layer which are in close contact in sequence, wherein the inner layer is a porous tantalum metal support, the middle layer is a solid biological ceramic support, the outer layer is a solid gelatin / sodium alginate composite hydrogel support, the inner layer, the middle layer and the outer layer are all of an arc-shaped shell structure, the radian of the arc-shaped shell is 120-240 degrees, and a cell loading cavity formed by continuous or discontinuous edges formed by protruding outwards from the surface of the outer layer and grooves formed between the edges is formed in the surface of the outer layer. The multilayer bionic joint is large in arc surface radian and suitable for repairing large-area osteochondral joint defects, and the repairing area can be larger than 1 / 2 of the area of thewhole joint. Cells are inoculated into the cell loading cavity, so that the adhesion rate of the cells is increased, and the problem that the surface of the outer layer of the bionic joint is smooth,so that the inoculated cells are not prone to adhesion is solved.

The invention provides an oral guided bone regeneration and repair system and a preparation method thereof, and belongs to the technical field of oral implantation. The oral guided bone regeneration and repair system comprises a bone filling support, a barrier film and bone cell growth guiding fibers, wherein the barrier film comprises a first arc-shaped surface and a second arc-shaped surface which are oppositely arranged in the thickness direction of the barrier film, and the first arc-shaped surface corresponds to a bone defect area of an oral cavity to be repaired; the bone filling supportis arranged on the first arc-shaped surface, and the bone cell growth guiding fibers are arranged on the bone filling support in a winding mode according to the preset orientation so as to guide directional growth of bone cells in the bone defect area. The oral guided regeneration and repair system provides enough space for growth of bone cells, has the capacity of resisting bacterium breeding and the characteristic of being completely degradable and absorbable, does not need to be taken out through a secondary operation, can also accelerate the bone growth speed, can shorten the treatment time of an oral cavity bone defect patient, and can improve the postoperative recovery probability of implantation.

The invention belongs to the field of medicine bioengineering and particularly relates to a drug composition containing glutathione (GSH) and an application of the drug composition. More particularly, the invention provides an application of reduced GSH to preparation of drugs for promoting diabetic implant bone integration, and further provides the drug composition containing GSH. The drug composition can promote diabetic implant bone integration and comprises GSH and other drugs, wherein the other drugs are preferably selected from resveratrol and / or insulin. Furthermore, the invention provides a drug preparation containing the drug composition and a preparation method of the drug preparation; the drug preparation is preferably selected from sustained-release microspheres.

The invention discloses a preparation method for a natural basin-based bionic structure bone scaffold. Silk protein and wool protein are taken as main raw materials, a silk protein solution and glycerinum are uniformly mixed according to the mass ratio of 60-120:20-60 and injected in a bone scaffold mold, a wool keratin solution is slowly injected into the mixed solution, and then through -40--20DEG C freezing and -72-5 DEG C vacuum freezing drying under 1.0*105-1.0 Pa, the silk protein / wool keratin bionic bone scaffold material is obtained. The prepared scaffold material is similar to the autogenous bone structure, the porosity rate reaches 70-95%, the hole diameter is uniform in distribution, the outer layer is compact, the hole diameter is smaller, the diameter range is 30-150 microns,the scaffold material has certain mechanical supporting performance, the diameter of inner holes is larger, the diameter range is 250-600 microns, and the scaffold material is suitable for migration,dependence and proliferation of cells.

The invention provides a personalized 3D printing porous titanium-based tantalum metal-coating bone fracture plate with osteoinductive activity. The plate is prepared by taking titanium metal powder or titanium alloy metal powder as a base material, and forming a tantalum coating on the surface of a porous titanium-based bone fracture plate which is prepared by 3D printing processing and has a void structure. The porous titanium-based tantalum metal-coating bone fracture plate has the porosity of 50-80%, the bending strength of 50-150 MPa, the elastic modulus of 2-30 GPa, the void diameter of200-800 [mu]m and the tantalum coating thickness of 30-60 [mu]m, and has sufficient strength and good osteoinductive performance. The implanted bone fracture plate conforming to the anatomical structure of the fracture part can form excellent bone integration with bone tissues, and the problem that a conventional bone fracture plate easily gets loosened and breaks after being implanted into a bodyfor a long time is avoided, so that permanent biological internal fixation is achieved.

The invention relates to a method for producing a water-absorbing swellable carboxymethyl chitosan sponge and its application, which comprises: adding a little chitosan powder or chitosan powder into the carboxymethyl chitosan solution with a quantitation of glycerin as the elasticizer, making every 100 ml solution with carboxymethyl chitosan of 1-5 g, chitosan powder or chitosan powder of 0.5-2 g and glycer of 1-5 g, stirring to foam and adding the environment-friendly ion-cross linker to cross-linking completely, cooling and drying to get the production. In the invention, using water-soluble materials as raw materials to avoid contamination, and using non-aldehyde group ion-cross linker to avoid residual toxicity of aldehyde group.

The invention discloses a degradable chitosan biomembrane as well as a preparation method and an application thereof. The degradable chitosan biomembrane comprises a chitosan multi-layer structural membrane main body frame which is provided with nature micropores and a multi-layer structure. The chitosan biomembrane is prepared by decalcifying, deproteinizing, removing acetophenetidin and manually layering in sequence. The biomembrane is degradable. Compared with an aporate structural biomembrane, the chitosan biomembrane serving as a tissue adhesion preventing membrane has the advantages that the porous structure is beneficial for the exchange of nutrient substances, and the biological tissue below the membrane can be prevented from extravasated blood and necrosis; the chitosan biomembrane serving as a guided tissue regeneration membrane has the beneficial effects that the porous structure is beneficial for the adhering and growth of osteoblast and osteocyte; the membrane does not need the secondary surgery for taking out and is the membrane material with high biocompatibility and safety and without toxicity and irritation, and the membrane material can be degraded and absorbed; the unique surface structure characteristics enable the effective separation of surgical wound and surrounding tissue, and thus the surgical wound can be protected effectively.

The invention provides an orthopedic internal fixation plate. The cross section on one side contacted with the backbone is an arc matched with the backbone, and the orthopedic internal fixation plate is made of PLLA or composite material of PLLA and HA. A preparation method for the orthopedic internal fixation plate comprises the following steps: a) manufacturing a die, and enabling the cross section of the orthopedic internal fixation plate on the one side contacted with the backbone to be the arc matched with the backbone; and b) putting a biodegradable polymer material into the die, and performing compression molding. The orthopedic internal fixation plate has a shape of a certain radian matched with the backbone aiming at the structure of the backbone of a human body, and can be effectively attached to the shape of the vertebral column, reconstruct and recover the stability of the vertebral column, prevent adhesion and slipping displacement, and relieve the pain of patients; and the orthopedic internal fixation plate made of the biodegradable polymer material has good biocompatibility and abrasion resistance, can be retained in the human body for long term, finally can be fully biodegraded, and does not need to be taken out through a secondary operation.

The invention discloses a degradable zinc alloy anastomotic apparatus and a preparation method thereof. The degradable zinc alloy anastomotic apparatus uses a degradable Zn-Li-Mn-Y alloy as a material, and the degradable Zn-Li-Mn-Y alloy includes the following components: 0-1 wt.% of Li, 0-1 wt.% of Mn and 0-1 wt.% of Y, without including 0, and the rest are Zn and unavoidable impurities. The degradable zinc alloy anastomotic apparatus includes any one of absorbable suture, medical zipper, anastomotic nail, anastomotic ring, anastomotic clip, anastomotic cannula or vascular clamp. The degradable zinc alloy anastomotic apparatus of the invention is excellent in mechanical properties, simple and convenient in operation, firm in anastomosis, capable of being decomposed in tissues or organs, capable of being fully absorbed by tissues and high in tissue compatibility.

The invention develops a hybrid cross-linked gel used for substituting vitreous body. Sodium hyaluronate nano-microsphere is covered by a biomacromolecule network, and the sodium hyaluronate concentration is in gradient distribution, thereby simulating the structure and composition change of the human vitreous body, wherein the sodium hyaluronate nano-microsphere is in light cross-linking, can form a reversible cross-linking network with the biomacromolecule, has a certain self-healing capacity, and is capable of effectively proloning the maintenance time in the body; and meanwhile, the compositions of the hybrid cross-linked gel are all the biomacromolecule and has good biocompatibility.

The invention provides a composition for preventing osteoporotic compression fractures, and a preparation method thereof. The composition comprises bone cement and allogeneic bone according to a mass ratio of 1:3 to 3:1. The composition can be used in a vertebral body reinforcement filler, reserves the three-dimensional grid structure of natural bone tissues, and has good cell compatibility and bone conduction effects; bone cells in the allogeneic bone grow in vertebral body marrows to realize uniform sclerotin and firm combination, so the adjacent segment endplate stress after vertebral body reinforcement operation is reduced, and adjacent vertebral body fractures are avoided; and adherence growth and gene expression of the bone cells are finally completely substituted by creeping, so the composition injected to the vertebral body does not cause vertebral body height loss and permanently becomes human body bone tissues after bone healing, and secondary operation removal is prevented.

The invention discloses a DFO-loaded artificial periosteal and a preparation method thereof, and belongs to the field of orthopedic implant materials. According to the DFO-loaded artificial periosteal, degradable polymer is used as a main raw material, DFO molecules with an osteogenic function are added, the DFO-high-polymer-material blending artificial periosteal is prepared by an electrostatic spinning method, through fiber blending, surface adsorption and / or loading, a polymeric microsphere is added, the mixture is mixed with a degradable high polymer material solution, and then DFO with amino is bonded to the surface of the DFO-high-polymer-material blending artificial periosteal by using chemical bonds in a selective use mode to achieve the effect of slow and long-lasting release. TheDFO-loaded artificial periosteal has good osteogenic activity, forms a barrier locally in the defect and can effectively prevent the invasion of pathogenic organisms and the occurrence of ectopic ossification, and the artificial periosteal has good biocompatibility, mechanical strength and degradability and can be used as a graft repair material for bone tissue defects.

The invention provides a mold for preparing a degradable joint balloon and a use method thereof. During using, a degradable polymer solution is prepared first; the prepared degradable polymer solutionis injected into a forming cavity of a combined mold through any runner; after the degradable polymer solution is solidified, a first external mold and a second external mold are detached to obtain afirst mold release product; dissolving a soluble internal mold in the first mold release product to obtain a second mold release product; changing clean water to clean the second mold release productfor multiple times; and after the second mold release product is dried, a degradable balloon can be prepared, wherein the degradable balloon is prepared by using a degradable polymer material with good biocompatibility, can be gradually degraded in vivo and absorbed by human body within 2-18 months, can have a supporting and stress buffering effect, cannot obstruct the repairing of normal tissuesand does not need to be taken out through second operation.

The invention provides a biological protein flexible nanometer friction electric generator and a preparation method thereof. The preparation method comprises the steps of preparing a biological protein solution; providing a raster template, coating the surface of the raster template with the biological protein solution, and performing drying and separating to obtain a biological protein membrane with a micro-nano raster structure on the single surface; adopting a human body implantable metal as a target material, and sputtering a friction electrode layer on the surface, without the raster structure, of the biological protein membrane; and performing cutting, taking the biological protein membrane as a first biological protein layer and a second biological protein layer, and taking the friction electrode layer as a first metal friction electrode layer and a second metal friction electrode layer to form the biological protein flexible nanometer friction electric generator. The electric generator disclosed in the invention is totally formed by human body degradable materials, so that immunoreaction is not caused after the electric generator is implanted into human body, without takingout through a secondary surgery; and through the raster structure, completeness and reflection strength of a reflective pattern can be checked, so that the output power of the electric generator canbe fed back in real time, and the degradation condition of the biological protein flexible nanometer friction electric generator can be monitored.

The invention relates to an absorbable rib fixing plate, and belongs to the technical field of medical supplies. A key point of the technical scheme is the absorbable rib fixing plate, the absorbablerib fixing plate includes an absorbable bone plate, an absorbable support plate and an absorbable screw; and the absorbable bone plate and the absorbable support plate are all in arc shape and matchedwith ribs, and the absorbable bone plate is provided with a plurality of connecting holes, a plurality of threaded holes corresponding to the connecting holes are formed in the absorbable support plate, after the absorbable screws penetrate through the connecting holes and the ribs, and the absorbable screws are matched with the threaded holes in a threaded mode so as to improve supporting and shaping effects on fractured ribs.

The present invention relates to a drug-loaded nanocomposite fiber membrane system and its preparation method and application. The drug-loaded nanocomposite fiber membrane system includes a first nanofiber layer, a second nanofiber layer and a third nanofiber layer; the first nanofiber layer A nanofiber layer includes poly(lactic-co-glycolic acid), polydioxanone, and medicine; the second nanofiber layer includes poly(lactic-co-glycolic acid), polyglycolic acid, and medicine; the third nanofiber The fibrous layer includes poly(lactic-co-glycolic acid), polyethylene glycol, and drug. The preparation method is as follows: respectively dissolving and mixing the polymer materials and drugs contained in each nanofiber layer to obtain three mixed solutions; performing electrospinning on the three mixed solutions in sequence to obtain the drug-loaded nanocomposite fiber membrane system . The system is a complete drug sustained release system from 0 days to 2.5 months, which realizes multi-gradient, multi-stage and long-acting drug release.

The invention provides a drug-loaded degradable vessel stent. The drug-loaded degradable vessel stent comprises a net-shaped stent body with fully-distributed micro-pores, and a drug loaded in the micro-pores; the drug-loaded degradable vessel stent is obtained by carrying out immersion treatment on the stent body in a drug solution to load the drug in the micro-pores of the stent body, and sterilizing, wherein the mass ratio of the stent body to the drugs is 10 to (1 to 2); the stent body is prepared by mixing silk fibroin, chitosan and a degradable polymer; the degradable polymer is preparedby mixing polyglycolic acid and polyamino acid according to the mass ratio of 1 to (2 to 3); the drug is a drug for treating hemadostenosis. The vessel stent has good biocompatibility and has relatively good mechanical property; the restenosis rate can be reduced, and the proliferation of endothelial progenitor cells and the formation of vessels are facilitated.

The invention relates to a biodegradable medical polymer tubing and a preparation method thereof. The invention provides a biodegradable medical polymer tubing with adjustable diameter and controllable wall thickness and a preparation method thereof. The tubing is made from biodegradable medical polymer material, and has inner diameter of 0.5-20 mm and thickness of 0.05-10 mm; and the biodegradable medical polymer material is one of a homopolymer, a copolymer, a star-shaped polymer and a crosslinking polymer of trimethylene carbonate, p-dioxanone, lactide, caprolactone and glycollide.

The invention discloses a subcutaneous soft tissue stitching instrument and a degradable metal stitching nail. The subcutaneous soft tissue stitching instrument comprises a nail pushing mechanism, a nailing mechanism and a nail storage cabin mechanism, the nail pushing mechanism comprises a supporting plate, a top plate, a nail pushing plate reset spring, a pressing block and a nail pushing plate, and the top plate is arranged at the top end of the supporting plate; the top plate is connected with the top face of the pressing block fixing end through a nail pushing plate reset spring, the nail pushing plate is slidably arranged on the supporting plate, and the end face of the pressing block fixing end is fixed to the top end of the side face of the nail pushing plate. The nailing mechanism comprises a nailing track used for containing suturing nails, and the nailing track is arranged at the bottom end of the nail pushing plate. And the nail storage cabin mechanism can continuously push the suturing staples into the nailing track. The effects of continuous nailing and rapid nailing are achieved through the nail pushing mechanism and the nail storage cabin mechanism, the suturing time of muscles or subcutaneous tissues is effectively saved, and surgical trauma and infection risks are effectively reduced; the suturing nail is made of biodegradable magnesium alloy or zinc alloy, can be automatically degraded and absorbed in vivo, and has no adverse side effect.