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Degradable multiporous faecula/PVA biological film and preparation method thereof

A technology of porous starch and biofilm, used in bandages, absorbent pads, medical science and other directions, can solve the problems of surrounding tissue healing effects, difficult to control degradation speed, etc., to achieve non-toxic degradation products, prevent congestion and necrosis, and simple preparation process Effect

Inactive Publication Date: 2012-09-05
BEIJING UNIV OF CHEM TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biggest defect of this type of membrane is that the degradation rate is difficult to control, and the degradation products are acidic substances, which have a great impact on the healing of surrounding tissues.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] After drying medical cornstarch and medical polyvinyl alcohol at 80°C, add 2 grams of cornstarch, 20 grams of polyvinyl alcohol and 4 grams of glycerin to 44g of deionized water, transfer to a single-necked flask, and use a spiral stirring blade at 80°C, Stir for 6 hours at 1000t / min to obtain a uniform and viscous film-forming solution; pour the film-forming solution into a round glass mold with a flat bottom and a diameter of 12cm to make the film-forming solution level off naturally, and the thickness of the film-forming solution is controlled at After the temperature of the film-forming solution drops to room temperature, put the mold containing the film-forming solution in a refrigerator at -80°C for 1 hour, transfer it to a freeze dryer, and vacuum-dry it at 0°C for 48 hours to obtain Degradable porous starch / PVA biofilm. The average pore diameter of the porous membrane is 5-10 μm.

Embodiment 2

[0025] After drying medical cornstarch and medical polyvinyl alcohol at 80°C, add 14 grams of cornstarch, 7 grams of polyvinyl alcohol, and 4 grams of glycerin to 525g of deionized water, transfer to a single-necked flask, and use a spiral stirring blade at 100°C , stirring at 1000t / min for 3 hours to obtain a uniform and viscous film-forming solution; pour the film-forming solution into a round glass mold with a flat bottom and a diameter of 12cm, so that the film-forming solution will naturally level and the thickness of the film-forming solution can be controlled After the temperature of the film-forming solution drops to room temperature at 1 mm, put the mold containing the film-forming solution in a refrigerator at -5°C for 3 hours, transfer it to a freeze dryer, and vacuum-dry it at 0°C for 48 hours to obtain Degradable porous starch / PVA biofilm. The average pore diameter of the porous membrane is 100-200 μm.

Embodiment 3

[0027] After drying medical cornstarch and medical polyvinyl alcohol at 80°C, add 4 grams of cornstarch, 16 grams of polyvinyl alcohol, and 4 grams of glycerin to 180g of deionized water, transfer to a single-necked flask, and use a spiral stirring blade at 95°C , stirred at 1000t / min for 4 hours to obtain a uniform and viscous film-forming solution; pour the film-forming solution into a round glass mold with a flat bottom and a diameter of 12cm, so that the film-forming solution will naturally level and the thickness of the film-forming solution can be controlled After the temperature of the film-forming solution drops to room temperature, place the mold containing the film-forming solution in a refrigerator at -5°C for 3 hours, transfer it to a freeze dryer, and then vacuum-dry it at -20°C for 4 hours. , vacuum drying at 0°C for 4 hours, vacuum drying at 10°C for 4 hours, and vacuum drying at 30°C for 1 hour to prepare a degradable porous starch / PVA biofilm. The average pore...

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Abstract

The present invention discloses degradable multiporous faecula / PVA biological membrane and preparation method thereof which belongs to biological medical material field. The invention aims to solve existing problems like membrane material inside implanted body not degradable, degrade speed too fast, degradation production easy initiate inflammation, mechanical property and biocompatibility bad etc. The biological membrane of the invention is composed of medical PVA and faecula with mass ratio between them from 10 to 0.5:1 and glycerol in 1-20% dry weight of PVA and faecula wherein diameter ofaperture of the membrane is 5-200 mu m. Osteolith in nano level, inorganic antimicrobial agent, tissue growth factor, and sustained-release drug can be included in the component of the membrane. The biological membrane of the invention can be obtained by dispersing component of formed membrane into water to get membrane forming liquid, placing the obtained membrane forming liquid in a mould for freeze dehydration. The process is simple, mechanical property and pore structure controllable, and can be applied sanitary field like tissue anti-adhesion membrane after surgery and leading tissue regenerating membrane.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a degradable biofilm which can be used to guide tissue regeneration and prevent tissue adhesion and a preparation method thereof, in particular to a porous biomedical film obtained by blending starch and polyvinyl alcohol. Membranes and methods for their preparation. Background technique [0002] Bio-membrane technology (Barrier Membrane Technique, referred to as BMT) is a new clinical treatment technology that has attracted widespread attention in the medical field in recent years. Since the 1990s, the use of artificial biofilms to guide the regenerative healing of body tissues has become an international hot research topic. [0003] Guide Tissue Regeneration (GTR) technology is a new technology developed in the late 1980s and early 1990s. The principle is to use the physical barrier function of the membrane to isolate the lesion area from the surrounding tissue...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/50A61L15/62A61L15/44A61L15/42A61L15/28A61L15/24A61L15/18C08L29/04C08L3/02C08K5/053C08J9/28
Inventor 石锐张立群田伟朱爱臣陈大福徐小川
Owner BEIJING UNIV OF CHEM TECH
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