Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Biodegradable medical polymer tubing and preparation method thereof

A biodegradable polymer technology, applied in the field of biodegradable medical polymer tubing and its preparation, can solve the problems of difficult biodegradable polymer processing high-precision tubing, etc., to save production costs, simple operation, and wide sources Effect

Active Publication Date: 2014-08-13
杨立群
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional polymer processing methods are largely difficult to process biodegradable polymers into high-precision tubing that can meet clinical requirements

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biodegradable medical polymer tubing and preparation method thereof
  • Biodegradable medical polymer tubing and preparation method thereof
  • Biodegradable medical polymer tubing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Assemble the PTFE mold core with an outer diameter of 2mm and the PTFE shell with an inner diameter of 3mm concentrically and coaxially, place them in the reactor, add 0.1mol trimethylene carbonate at the same time, and vacuumize for 3 Add stannous octoate as a catalyst after the first time, the molar ratio of trimethylene carbonate to catalyst is 1000:1, vacuumize 3 times under reduced pressure (vacuum degree <15Pa), seal the tube under vacuum conditions, and perform bulk polymerization reaction at 130°C for 24h After taking it out, cooling and demolding can obtain a polytrimethylene carbonate pipe material with an inner diameter of 2 mm and a wall thickness of 0.5 mm.

Embodiment 2

[0042] After treating the stainless steel mold core with an outer diameter of 3mm and the stainless steel shell with an inner diameter of 5mm with a fluorine release agent, assemble them together concentrically and coaxially and place them in a reactor. After vacuuming for 3 times, stannous octoate was added as a catalyst, the molar ratio of caprolactone to catalyst was 3000:1, vacuum was pumped for 3 times under reduced pressure (vacuum degree <15Pa), and the tube was sealed under vacuum conditions. After bulk polymerization at 150° C. for 48 hours, take it out, cool and demould to obtain a polycaprolactone pipe with an inner diameter of 3 mm and a wall thickness of 1 mm.

Embodiment 3

[0044] After the glass mold core with an outer diameter of 5mm and the glass shell with an inner diameter of 10mm are silanized, they are assembled together concentrically and coaxially and placed in a reactor, and 0.3mol of trimethylene carbonate and 0.7mol of caprolactone are added at the same time And 0.001mol cross-linking agent 5,5'-(propane-diyl)dioxepan-2-one, add stannous octoate as a catalyst after decompression and vacuuming for 3 times, the addition amount is 0.0002mol, decompression Vacuum 3 times (vacuum degree <15Pa), seal the tube under vacuum condition. Take it out after bulk polymerization at 110°C for 36 hours, cool and demould to obtain a trimethylene carbonate-caprolactone cross-linked copolymer pipe with an inner diameter of 5 mm, a wall thickness of 2.5 mm, and a cross-linking density of 0.2%. According to the preparation method of Example 3, adjusting the copolymerization ratio of TMC and CL and the usage amount of the crosslinking agent BTB can obtain t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a biodegradable medical polymer tubing and a preparation method thereof. The invention provides a biodegradable medical polymer tubing with adjustable diameter and controllable wall thickness and a preparation method thereof. The tubing is made from biodegradable medical polymer material, and has inner diameter of 0.5-20 mm and thickness of 0.05-10 mm; and the biodegradable medical polymer material is one of a homopolymer, a copolymer, a star-shaped polymer and a crosslinking polymer of trimethylene carbonate, p-dioxanone, lactide, caprolactone and glycollide.

Description

Technical field: [0001] The invention belongs to the technical field of polymer materials and the field of biomedical engineering, and more specifically relates to a biodegradable medical polymer pipe and a preparation method thereof. Background technique: [0002] Biodegradable medical polymer tubing has good biodegradability and excellent biocompatibility, and can be degraded into small molecular compounds in the body and metabolized, absorbed or excreted by the body. It is used in implantable medical devices, drug slow control In the clinical application of release system and tissue engineering scaffold, there is no need for secondary surgery, which can reduce the pain of patients, simplify the operation procedure, improve the treatment effect, prolong the life of patients and improve the quality of life of patients. Therefore, biodegradable medical polymer tubing has been more and more widely used in the field of biomedicine, and has effectively promoted the development ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/06A61L27/18A61L31/06
Inventor 杨立群顾忠伟李建新关艳敏孟舒
Owner 杨立群
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com