Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medical implanted degradable composite bar and preparing method thereof

A technology of composite rods and magnesium alloys, applied in pharmaceutical formulations, medical science, coatings, etc., can solve problems such as atrophy, non-degradable, and natural bone function degradation, and achieve good mechanical properties, good biocompatibility, and bonding strength high effect

Active Publication Date: 2018-12-18
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
View PDF8 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the implant materials mainly used clinically include stainless steel, titanium and titanium alloy, Co-Cr alloy, etc., but the clinical application of these materials has the following problems: ①The elastic modulus of metal materials is much higher than that of human bone modulus, which has a great "stress shielding" effect on local bone tissue, which may lead to the possibility of degeneration or even atrophy of natural bone function; ② is not degradable in the body, and should be used as temporary implant materials such as vascular stents, bone nails, and bone plates , bone needles, need to perform a second operation to remove
In addition, both magnesium alloys and zinc alloys have problems such as no osteoinductive activity.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical implanted degradable composite bar and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Preparing magnesium alloy rods, including the following steps:

[0039] 1) Alloy ingredients: The chemical composition is calculated by mass percentage: CaO 8%, Zn 6%, Sr 3%, Ce 1.0%, and the rest is Mg;

[0040] 2) Put the prepared raw materials into the non-consumable electrode water-cooled copper crucible electric arc furnace, and evacuate the furnace to 8.5×10 －4 Pa, the argon gas with a purity of 99.99% was introduced for 3 times of repeated gas scrubbing, and then smelted by electricity (temperature 1750°C, holding time 60min) and cast into ingots, then the ingots were turned over 180° and remelted 5 times to ensure the uniformity of components ;

[0041] 3) The ingot is subjected to homogenization treatment. The homogenization treatment is held at 380°C for 3 hours; then the temperature is raised to 420°C for 5 hours, and then the furnace is cooled to room temperature to obtain an ingot;

[0042]4) Heat the ingot at 400°C for 35 minutes, then carry out high...

Embodiment 2

[0064] (1) Preparing magnesium alloy rods, including the following steps:

[0065] 1) Alloy ingredients: The chemical composition is calculated by mass percentage: CaO 8.5%, Zn 7%, Sr 4%, Ce 1.2%, and the rest is Mg;

[0066] 2) Put the prepared raw materials into the non-consumable electrode water-cooled copper crucible electric arc furnace, and evacuate the furnace to 8.5×10 －4 Pa, the argon gas with a purity of 99.99% was introduced for 3 times of repeated gas scrubbing, and then smelted by electricity (temperature 1750°C, holding time 60min) and cast into ingots, then the ingots were turned over 180° and remelted 5 times to ensure the uniformity of components ;

[0067] 3) The ingot is subjected to homogenization treatment. The homogenization treatment is carried out at 380°C for 3 hours, then heated to 420°C for 5 hours, and then furnace cooled to room temperature to obtain an ingot;

[0068] 4) Heat the ingot at 400°C for 35 minutes, then carry out high-temperature pla...

Embodiment 3

[0090] (1) Preparing magnesium alloy rods, including the following steps:

[0091] 1) Alloy ingredients: The chemical composition is calculated by mass percentage: CaO 9%, Zn 8%, Sr 4.5%, Ce 1.1%, and the rest is Mg;

[0092] 2) Put the prepared raw materials into the non-consumable electrode water-cooled copper crucible electric arc furnace, and evacuate the furnace to 8.5×10 －4 Pa, the argon gas with a purity of 99.99% was introduced for 3 times of repeated gas scrubbing, and then smelted by electricity (temperature 1750°C, holding time 60min) and cast into ingots, then the ingots were turned over 180° and remelted 5 times to ensure the uniformity of components ;

[0093] 3) The ingot is subjected to homogenization treatment. The homogenization treatment is held at 380°C for 3 hours; then the temperature is raised to 420°C for 5 hours, and then the furnace is cooled to room temperature to obtain an ingot;

[0094] 4) Heat the ingot at 400°C for 35 minutes, then carry out h...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
tensile strengthaaaaaaaaaa
tensile strengthaaaaaaaaaa
tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention provides a medical implanted degradable composite bar and a preparing method thereof. The medical implanted degradable composite bar is characterized in that the innermost layer is a magnesium alloy, the middle layer is a zinc alloy, the zinc alloy and the magnesium alloy are connected in the form of a dovetail groove, the liquid zinc alloy is poured around the solid magnesium alloyat the high temperature, so that the magnesium alloy and the zinc alloy are in metallurgical bonding, and the outermost layer is a biological coating. The magnesium alloy comprises chemical componentsincluding, by mass percent, 8%-15% of CaO, 3%-10% of Zn, 2%-8% of Sr, 0.8%-2% of Ce and the balance Mg. The zinc alloy comprises chemical components including, by mass percent, 0.1%-1.0% of Mg, 0.5%-2.0% of Mn, 0.05%-0.6% of Sr, 0.1%-0.5% of Sn, 0.08%-0.6% of La and the balance Zn. The biological coating comprises chemical components including, by mass percent, 50%-65% of nano beta-Ca3(PO4)2 andnano CaCO3 composite particles, 3%-8% of nano silver particles and the balance polylactic acid, wherein the mass ratio of nano beta-Ca3(PO4)2 to nano CaCO3 is 1:2. The composite bar has good mechanical performance, the medical requirements can be met, integral materials can be completely degraded, and taking-out through the second operation is not needed.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, in particular to a degradable composite rod for medical implantation and a preparation method thereof. Background technique [0002] At present, the implant materials mainly used clinically include stainless steel, titanium and titanium alloy, Co-Cr alloy, etc., but the clinical application of these materials has the following problems: ①The elastic modulus of metal materials is much higher than that of human bone modulus, which has a great "stress shielding" effect on local bone tissue, which may lead to the possibility of degeneration or even atrophy of natural bone function; ② is not degradable in the body, and should be used as temporary implant materials such as vascular stents, bone nails, and bone plates When the spicule is removed, a second operation is required to remove it. In this case, biodegradable absorbing materials in vivo have become a research hotspot of biomateri...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/02C22C1/06C21D8/06C22F1/06C22C23/04C22C18/00B22D19/16C22F1/16A61L31/02A61L31/08A61L31/10A61L31/14B21C37/04
CPCA61L31/022A61L31/086A61L31/088A61L31/10A61L31/148A61L2400/12B21C37/045B22D19/16C21D8/06C22C1/02C22C1/06C22C18/00C22C23/04C22F1/06C22F1/165C08L67/04
Inventor 谷晨熙李宇许建中田科张弛孙俊魁郝钢
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com