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Drug-carrying nanocomposite fiber membrane system and preparation method and application thereof

A technology of composite fiber membranes and drug-loaded nanometers, applied in the field of fiber membranes, can solve the problems of prolonging drug release time and inability to achieve multi-stage drug release, and achieve long-term drug release effects

Active Publication Date: 2019-06-21
SHENZHEN GUANGYUAN BIOMATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, several nanofibrous membranes involved in the above patents can only prolong the drug release time to a certain extent, and cannot achieve effective and controllable multi-stage drug release.

Method used

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  • Drug-carrying nanocomposite fiber membrane system and preparation method and application thereof
  • Drug-carrying nanocomposite fiber membrane system and preparation method and application thereof
  • Drug-carrying nanocomposite fiber membrane system and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] This embodiment provides a drug-loaded nanocomposite fiber membrane system, the drug-loaded nanocomposite fiber membrane system includes a first nanofiber layer, a second nanofiber layer and a third nanofiber layer;

[0073] The first nanofibrous layer comprises polylactic acid-glycolic acid copolymer (PLGA) (molecular weight is 60000), polydioxanone (PDO) (intrinsic viscosity is 1.2-2.4dL / g) and paclitaxel, PLGA and The mass ratio of PDO is 9:1, paclitaxel accounts for 15% of the total mass of PLGA and PDO, and the molar ratio of LA structural unit and GA structural unit in PLGA is 1:1;

[0074]The second nanofibrous layer comprises polylactic acid-glycolic acid copolymer (PLGA) (molecular weight is 80000), polyglycolic acid (PGA) (intrinsic viscosity is 0.5-1.8dL / g) and paclitaxel, the mass ratio of PLGA and PGA is 93:7, paclitaxel accounts for 10% of the total mass of PLGA and PGA, and the molar ratio of LA structural unit to GA structural unit in PLGA is 3:1;

[00...

Embodiment 2

[0082] This embodiment provides a drug-loaded nanocomposite fiber membrane system, the drug-loaded nanocomposite fiber membrane system includes a first nanofiber layer, a second nanofiber layer and a third nanofiber layer;

[0083] The first nanofibrous layer comprises poly(lactic-co-glycolic acid) (PLGA) (molecular weight is 120000), polydioxanone (PDO) (intrinsic viscosity is 2.4-4.8dL / g) and doxorubicin, The mass ratio of PLGA to PDO is 8:2, doxorubicin accounts for 15% of the total mass of PLGA and PDO, and the molar ratio of LA structural unit to GA structural unit in PLGA is 1:1;

[0084] The second nanofibrous layer comprises polylactic-co-glycolic acid (PLGA) (molecular weight is 40000), polyglycolic acid (PGA) (intrinsic viscosity is 2.5-4.0dL / g) and doxorubicin, PLGA and PGA The mass ratio is 6:4, doxorubicin accounts for 10% of the total mass of PLGA and PGA, and the molar ratio of LA structural unit to GA structural unit in PLGA is 3:1;

[0085] Described the 3rd ...

Embodiment 3

[0092] This embodiment provides a drug-loaded nanocomposite fiber membrane system, the drug-loaded nanocomposite fiber membrane system includes a first nanofiber layer, a second nanofiber layer and a third nanofiber layer;

[0093] The first nanofiber layer includes poly(lactic-co-glycolic acid) (PLGA) (molecular weight is 40000), polydioxanone (PDO) (intrinsic viscosity is 2.4-4.8dL / g) and 5-fluorouracil, The mass ratio of PLGA to PDO is 7:3, 5-fluorouracil accounts for 15% of the total mass of PLGA and PDO, and the molar ratio of LA structural unit to GA structural unit in PLGA is 1:1;

[0094] The second nanofibrous layer includes polylactic acid-glycolic acid copolymer (PLGA) (molecular weight is 200000), polyglycolic acid (PGA) (intrinsic viscosity is 8.0-9.0dL / g) and 5-fluorouracil, PLGA and PGA The mass ratio is 7:3, 5-fluorouracil accounts for 10% of the total mass of PLGA and PGA, and the molar ratio of LA structural unit to GA structural unit in PLGA is 3:1;

[0095...

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Abstract

The invention relates to a drug-carrying nanocomposite fiber membrane system and a preparation method and application thereof. The drug-carrying nanocomposite fiber membrane system comprises a first nanofiber layer, a second nanofiber layer and a third nanofiber layer; the first nanofiber layer includes a polylactic acid-hydroxyacetic acid copolymer, polydioxanone and drugs; the second nanofiber layer includes a polylactic acid-hydroxyacetic acid copolymer, polyglycolic acid and drugs; the third nanofiber layer includes polylactic acid-hydroxyacetic acid copolymer, polyethylene glycol and drugs. The preparation method includes: respectively dissolving and mixing polymer materials and drugs contained in the nanofiber layers to obtain three kinds of mixed solutions; subjecting the mixed solutions to electrostatic spinning in sequence to obtain the drug-carrying nanocoposite fiber membrane system. The drug-carrying nanocomposite fiber membrane system is a complete 0-day to 2.5-month drugsustained release system, achieving multi-gradient, multi-stage and long-term drug release.

Description

technical field [0001] The invention belongs to the technical field of fiber membranes, and in particular relates to a drug-loaded nanocomposite fiber membrane system and its preparation method and application. Background technique [0002] There are many risk factors for recurrence after tumor resection. The tumor center can be completely removed by surgical resection. For most cancer sites, due to the functionality of the organ, a large area cannot be removed during resection, which makes the surrounding calcification The resection of the area is not clean, so that the recurrence rate of cancer after surgery is greatly increased. Traditional postoperative adjuvant chemotherapy can eliminate residual tumors and subclinical lesions, but chemotherapy drugs spread throughout the body with blood circulation, which is toxic to healthy organs and tissues and has low drug utilization. The method of targeted chemotherapy is particularly important. [0003] How to specifically des...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/10A61K47/34A61K31/337A61K31/513A61K31/704A61K33/243A61P35/00D01D5/00D04H1/728
CPCA61K9/70A61K31/337A61K31/513A61K31/704A61K33/243A61K47/10A61K47/34A61P35/00D04H1/728A61K47/32D01F1/10D01F6/84D01D5/0038D01D5/00D04H3/011B32B2262/0276B32B2307/716B32B2535/00B32B2250/20B32B5/02B32B5/26B32B2262/02B32B2250/03A61K9/7007D01D5/0007
Inventor 韩志超许杉杉伍家恩王岚
Owner SHENZHEN GUANGYUAN BIOMATERIAL CO LTD
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