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Mussel mucoprotein gel for repairing and reliving itching and preparation method of mussel mucoprotein gel

A technology of mussel mucin and protein gel, which is applied to peptide/protein components, pharmaceutical formulations, aerosol delivery, etc., to achieve the effects of good biocompatibility, fast and effective adhesion, and long degradation cycle

Inactive Publication Date: 2015-05-27
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is a lack of a kind of repairing and antipruritic mussel mucin gel with good biocompatibility with human body and its preparation method

Method used

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  • Mussel mucoprotein gel for repairing and reliving itching and preparation method of mussel mucoprotein gel
  • Mussel mucoprotein gel for repairing and reliving itching and preparation method of mussel mucoprotein gel
  • Mussel mucoprotein gel for repairing and reliving itching and preparation method of mussel mucoprotein gel

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preparation example Construction

[0035] The preparation method of repairing antipruritic mussel mucin gel of the present invention comprises the following steps:

[0036] (1) Equipment preparation: clean and sterilize all equipment;

[0037] (2) Matrix swelling and sterilization: take polymer matrix material, humectant, surfactant, preservative, stabilizer and bacteriostatic agent according to the ratio of the above-mentioned mass percentage, then after it is mixed, add purified water to naturally Swell for 24 hours, stir evenly and adjust the pH value of the solution to 3.8-5.8 with a pH value regulator, pressurize at 0.1-0.15MPa, 120-130°C for 30 minutes, and cool for later use;

[0038] (3) Protein sterilization and filtration: 1%-2% protein protectant in the treated mussel mucin raw material liquid, then it is diluted to 1%-2% of the original concentration with purified water. Sterilize with a 0.22 μm filter membrane under bacterial conditions to obtain a mussel mucin solution for use;

[0039] (4) Gel ...

Embodiment 1

[0045] Produce 5000g repair antipruritic mussel mucin gel, described repair antipruritic mussel mucin gel is composed of the following components by mass percentage:

[0046]

[0047] The pH value of the mussel mucin gel for repairing and relieving itching is 3.8.

[0048] The polymer matrix material is carbomer-940 and hydroxypropyl methylcellulose.

[0049] Described humectant is glycerin and ethylene glycol.

[0050] The surfactant is Tween 80.

[0051] The preservative is ethyl hydroxybenzoate; the stabilizer is low-molecular dextran and ethylenediaminetetraacetic acid.

[0052] The antibacterial agent is ethyl hydroxybenzoate and dimethyl fumarate; the pH regulator is citric acid, sorbic acid, and trisodium bicarbonate.

[0053] The preparation method of repairing antipruritic mussel mucin gel of the present invention comprises the following steps:

[0054] (1) Equipment preparation: clean and sterilize all equipment;

[0055] (2) Matrix swelling and sterilization...

Embodiment 2

[0060] The difference between embodiment 2 and embodiment 1 is: the production of 5000g repairing and antipruritic mussel mucin gel, the repair and antipruritic mussel mucin gel consists of the following components by mass percentage:

[0061]

[0062] The pH value of the mussel mucin gel for repairing and relieving itching is 5.8.

[0063] The polymer matrix material is methyl cellulose and hydroxymethyl cellulose. Described humectant is sorbitol and glycerol. The surfactant is sorbitan fatty acid and sodium dodecylsulfonate. The stabilizer is disodium edetate and sodium calcium edetate. The bacteriostatic agent is a lower fatty acid ester; the pH regulator is citric acid.

[0064] The preparation method of the repairing and antipruritic mussel mucin gel of the present invention comprises the following steps: the preparation method of the repairing and antipruritic mussel mucin gel of the present invention comprises the steps of:

[0065] In step (2), matrix swelling a...

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Abstract

The invention discloses a mussel mucoprotein gel for repairing and reliving itching. The mussel mucoprotein gel is prepared from the following components in percentage by weight: 0.15%-0.2% of mussel mucoprotein, 0.5%-2% of a macromolecule host material, 3%-10% of a humectant, 1%-5% of a surfactant, 0.1%-0.5% of a preservative, 1%-2% of a protein protectant, 0.5%-3% of a stabilizer, 0.5%-1% of a bacteriostatic agent, 0.8%-5.2% of a pH modifier and the balance of purified water. The mussel mucoprotein gel has good biological adhesion, is rapidly and effectively adhered to a wound surface, is capable of rapidly reliving itching and easing pain, and has the advantages of being low in immunogenicity, good in biocompatibility with a human body, convenient to use, free of thrill to skin, safe, nontoxic and free of bad reaction.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a mussel mucin gel for repairing and relieving itching and a preparation method thereof. Background technique [0002] Mussel adhesive protein MAP, also known as Mytilus edulis foot protein Mefp, comes from the marine shellfish Mytilus edulis, which has the ability to withstand the impact of waves in the sea. A protein glue is produced and stored in special glands, which is released to solid surfaces such as rocks through fibrils to form a water-resistant bond to fix itself. Studies on glass have shown that the plaque formed by protein glue, extending from the plaque, has a strong tensile strength (106-107 mewton / meter2), and the material in the plaque contains mussel mucin MAP. [0003] The content of Lys in mussel mucin (MAP) is 20%, and the content of DOPA is 11%. Mussel mucin promotes healing by forming positively charged microscopic biological scaffol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/06A61K47/24A61P17/04A61P17/02
Inventor 姚正军李琳周金堂刘沛江
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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