A drug-loaded nanocomposite fiber membrane system and its preparation method and application
A composite fiber membrane and drug-loaded nanotechnology, which is applied in the field of fiber membranes, can solve the problems of prolonging drug release time, unable to achieve multi-stage drug release, etc., and achieve the effect of long-term drug release and drug efficacy.
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Embodiment 1
[0072] This embodiment provides a drug-loaded nanocomposite fiber membrane system, the drug-loaded nanocomposite fiber membrane system includes a first nanofiber layer, a second nanofiber layer and a third nanofiber layer;
[0073] The first nanofibrous layer includes poly(lactic-co-glycolic acid) (PLGA) (molecular weight is 60000), polydioxanone (PDO) (intrinsic viscosity is 1.2-2.4dL / g) and paclitaxel, PLGA and The mass ratio of PDO is 9:1, paclitaxel accounts for 15% of the total mass of PLGA and PDO, and the molar ratio of LA structural unit and GA structural unit in PLGA is 1:1;
[0074]The second nanofibrous layer includes polylactic acid-glycolic acid copolymer (PLGA) (molecular weight is 80000), polyglycolic acid (PGA) (intrinsic viscosity is 0.5-1.8dL / g) and paclitaxel, and the mass ratio of PLGA to PGA is is 93:7, paclitaxel accounts for 10% of the total mass of PLGA and PGA, and the molar ratio of LA structural unit to GA structural unit in PLGA is 3:1;
[0075] Th...
Embodiment 2
[0082] This embodiment provides a drug-loaded nanocomposite fiber membrane system, the drug-loaded nanocomposite fiber membrane system includes a first nanofiber layer, a second nanofiber layer and a third nanofiber layer;
[0083] The first nanofibrous layer comprises poly(lactic-co-glycolic acid) (PLGA) (molecular weight is 120000), polydioxanone (PDO) (intrinsic viscosity is 2.4-4.8dL / g) and doxorubicin, The mass ratio of PLGA to PDO is 8:2, doxorubicin accounts for 15% of the total mass of PLGA and PDO, and the molar ratio of LA structural unit to GA structural unit in PLGA is 1:1;
[0084] The second nanofibrous layer includes polylactic-co-glycolic acid (PLGA) (molecular weight: 40,000), polyglycolic acid (PGA) (intrinsic viscosity: 2.5-4.0dL / g) and doxorubicin, PLGA and PGA The mass ratio is 6:4, doxorubicin accounts for 10% of the total mass of PLGA and PGA, and the molar ratio of LA structural unit to GA structural unit in PLGA is 3:1;
[0085] Described the 3rd nano...
Embodiment 3
[0092] This embodiment provides a drug-loaded nanocomposite fiber membrane system, the drug-loaded nanocomposite fiber membrane system includes a first nanofiber layer, a second nanofiber layer and a third nanofiber layer;
[0093] The first nanofiber layer includes poly(lactic-co-glycolic acid) (PLGA) (molecular weight is 40000), polydioxanone (PDO) (intrinsic viscosity is 2.4-4.8dL / g) and 5-fluorouracil, The mass ratio of PLGA to PDO is 7:3, 5-fluorouracil accounts for 15% of the total mass of PLGA and PDO, and the molar ratio of LA structural unit to GA structural unit in PLGA is 1:1;
[0094] The second nanofibrous layer includes poly(lactic-co-glycolic acid) (PLGA) (molecular weight: 200,000), polyglycolic acid (PGA) (intrinsic viscosity: 8.0-9.0dL / g) and 5-fluorouracil, PLGA and PGA The mass ratio is 7:3, 5-fluorouracil accounts for 10% of the total mass of PLGA and PGA, and the molar ratio of LA structural unit to GA structural unit in PLGA is 3:1;
[0095] The third n...
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