Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition for preventing osteoporotic compression fractures, and preparation method thereof

A technology for compression fractures and osteoporosis, applied in the field of medical materials, can solve the problems of lack of bone conduction and osteoinduction, reducing the incidence of refractures of adjacent segments, and different mechanical strengths, achieving good bone conduction, Good cytocompatibility, reduced endplate stress

Inactive Publication Date: 2017-03-29
东莞市第三人民医院
View PDF6 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this material has obvious defects: pure mechanical support, no osteoconduction and osteoinduction; it cannot be absorbed and replaced by its own tissue; the elastic modulus is too high. After vertebroplasty, the diseased vertebral body and adjacent vertebrae The mechanical strength of the body is different, and the stress concentration of the spine has the risk of causing adjacent vertebral fractures
[0003] At present, there is a lack of a filling material that can provide mechanical support for the osteoporotic vertebral body and at the same time reduce the stress concentration of the spine and cause adjacent vertebral fractures. The incidence of refracture is significant

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition for preventing osteoporotic compression fractures, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] In this embodiment, the composition for preventing osteoporotic compression fractures includes bone cement and allogeneic bone at a mass ratio of 1:1, wherein the bone cement is composed of a solid phase and a liquid phase, and the mass of the solid phase is 20g, the liquid phase quality is 9.4g, and described solid phase comprises the following components of mass percentage: 67.5% polymethyl methacrylate, 30.0% barium sulfate and 2.5% benzoyl peroxide; Described liquid phase comprises mass percentage Components as follows: 99.1% methyl methacrylate monomer, 0.8925% N,N-dimethyl polyaniline and 0.0075% hydroquinone.

[0045] The preparation method is as follows:

[0046] Add 29.4g of Bio-gene allogeneic cancellous bone powder (particle size: 0.05-0.2mm) into a container containing 20g of Mendec bone cement aseptic powder (i.e. solid phase), mix the two thoroughly, then add 9.4g Liquid phase (sterile liquid), fully stirred for 2 minutes to obtain a composition for preve...

Embodiment 2

[0048] In this embodiment, the composition for preventing osteoporotic compression fractures includes bone cement and allogeneic bone at a mass ratio of 1:2, wherein the bone cement consists of a solid phase and a liquid phase, and the mass of the solid phase is 15g, the liquid phase quality is 10g, and described solid phase comprises the following components of mass percentage: 65% polymethyl methacrylate, 30% barium sulfate and 5% benzoyl peroxide; Described liquid phase comprises mass percentage as follows Components: 95% methyl methacrylate monomer, 4.995% N,N-dimethyl polyaniline and 0.005% hydroquinone.

[0049] The preparation method is as follows:

[0050] Add 50g of Bio-gene allogeneic cancellous bone powder (particle size: 0.05-0.2mm) into a container filled with 15g of Mendec bone cement sterile powder (i.e. solid phase), mix the two thoroughly, then add 10g of liquid phase (sterile liquid), fully stirred for 2 minutes to obtain a composition for preventing osteopo...

Embodiment 3

[0052] In this embodiment, the composition for preventing osteoporotic compression fractures includes bone cement and allogeneic bone at a mass ratio of 3:1, wherein the bone cement consists of a solid phase and a liquid phase, and the mass of the solid phase is 20g, the liquid phase quality is 6.7g, and described solid phase comprises the following components of mass percentage: 70% polymethyl methacrylate, 29.0% barium sulfate and 1.0% benzoyl peroxide; Described liquid phase comprises mass percentage Components as follows: 99.4% methyl methacrylate monomer, 0.59% N,N-dimethyl polyaniline and 0.01% hydroquinone.

[0053] The preparation method is as follows:

[0054] Add 8.9g of Bio-gene allogeneic cancellous bone powder (particle size: 0.05-0.2mm) into a container containing 20g of Mendec bone cement aseptic powder (i.e. solid phase), mix the two thoroughly, then add 6.7g Liquid phase (sterile liquid), fully stirred for 2 minutes to obtain a composition for preventing oste...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
diameteraaaaaaaaaa
lengthaaaaaaaaaa
Login to View More

Abstract

The invention provides a composition for preventing osteoporotic compression fractures, and a preparation method thereof. The composition comprises bone cement and allogeneic bone according to a mass ratio of 1:3 to 3:1. The composition can be used in a vertebral body reinforcement filler, reserves the three-dimensional grid structure of natural bone tissues, and has good cell compatibility and bone conduction effects; bone cells in the allogeneic bone grow in vertebral body marrows to realize uniform sclerotin and firm combination, so the adjacent segment endplate stress after vertebral body reinforcement operation is reduced, and adjacent vertebral body fractures are avoided; and adherence growth and gene expression of the bone cells are finally completely substituted by creeping, so the composition injected to the vertebral body does not cause vertebral body height loss and permanently becomes human body bone tissues after bone healing, and secondary operation removal is prevented.

Description

technical field [0001] The invention belongs to the field of medical materials, and relates to a composition for strengthening osteoporotic compression fractures and a preparation method thereof. Background technique [0002] Vertebral compression fractures are the most common type of osteoporotic fractures, often occurring in the elderly and postmenopausal women. With the aging population in my country, the number of patients with osteoporotic vertebral compression fractures is increasing year by year. According to statistics, there are about 1.81 million new cases of osteoporotic vertebral compression fractures every year. Osteoporotic vertebral compression fractures are mainly manifested as low back pain, difficulty standing and walking and having to rest in bed, various complications follow, further aggravation of spinal kyphosis, cardiopulmonary dysfunction, and mortality obviously increase. The conservative treatment of osteoporotic vertebral compression fractures ma...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/56A61L27/18A61L27/16A61L27/02
CPCA61L27/3608A61L27/025A61L27/16A61L27/18A61L27/56A61L2400/06A61L2430/02C08L33/12C08L79/02
Inventor 王志坤
Owner 东莞市第三人民医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com