67 results about "Collagen degradation" patented technology

The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker.

Biomarkers for diagnosis and monitoring of vascular aneurysms are described in the context of the use of assays to measure a plurality of these biomarkers. Tissue degeneration, particularly elastin and/or collagen degradation, can be monitored within patient blood (serum) and/or urine to diagnose the presence, the progression, or the likelihood of rupture of aneurismal disease. Additionally, enzymes responsible for this degradation and other biomarkers responsible for the activation or inhibition of these enzymes can be monitored additionally or alternatively. Prompt diagnosis can provide the opportunity for intervention and potentially increase the health of patients by tempering the development of debilitating and life-threatening vascular aneurysms.

Polyelectrolyte based bioactive super-absorbent material ionotropically crosslinked/neutralized involving polyvalent carboxylic acids, citrate, Kojic Acid, Alpha Arbutin along with fish scale collagen cross linked with other polyelectrolyte biopolymers preferably selected from chitosan, alginate or their combinations is used in this invention. The advancement is also directed to process of extraction of collagen of high purity from fresh water fish scale by salt and alkaline washing, crushing followed by continuous dialysis thereby minimizing the chance of collagen degradation. Also disclosed are different forms of collagen-chitosan composite biomaterial using citrate as the neutralizing buffer in combination with antimicrobial agent, antioxidant, skin plumper and melanin reducer wherein the different forms of collagen chitosan particularly sheet, flakes, powder, gel, particles, fiber, film, spray etc. reveal efficient wound healing properties. The advancement is thus directed to find wide application in various dermal wound healing, tissue engineering, 3D cell culture, cell expansion and cell delivery vehicle, mimicking the in vivo situation in dynamic condition, cosmetics and different other health care applications.

The invention discloses a degrading collagen-polyurethane waterborne wood adhesive, which is prepared from the following ingredients in parts by weight: 100 to 150 parts of isocyanate, 50 to 75 parts of polyester type polyalcohol, 0.1 to 0.2 part of catalysts, 30 to 45 parts of hydrophilic extended chain agents, 10 to 15 parts of micromolecule diglycol chain extenders, 20 to 30 parts of neutralizing agents and 50 to 110 parts of degradation collagen. The invention also discloses a preparation method of the degradation collagen-polyurethane water-based wood adhesive. A chrome shaving waste degradation product generated in a leather production process is used as a raw material; a path is increased for the resource reutilization of the chrome shaving waste; the corresponding economic benefits are brought; meanwhile, the environment pressure is relieved to a certain degree. Meanwhile, through the copolymerization modification with waterborne polyurethane, the problem of high cost of the single polyurethane is solved; meanwhile, the adhesive intensity, the water-resistant performance and the like of the chrome shaving collagen degradation substances are effectively improved.

The invention relates to an injection (intracutaneous injection) for correcting skin wrinkles and a preparation method thereof. The injection is prepared from the following components by mass: 3-6g/L of high molecular polysaccharide, 50-200mg/L of amino acid, 2-10mg/L of water-soluble vitamin and 2-5g/L of L-carnosine. A sample prepared according to the formula is capable of supplying extracellular matrix to skin and promoting synthesis of spontaneous collagen of skin. The injection has the function of a traditional filling material for supplying lost extracellular matrix, is capable of promoting synthesis of collagen and solving the problem of wrinkled and loose skin caused be senility. Furthermore, compared with a conventional filling material, the injection is lower in viscosity and is more suitable for intracutaneous injection. According to the injection prepared by the method, the problem of sodium hyaluronate and collagen degradation of skin in the aging process can be solved by means of the intracutaneous injection, and an anti-wrinkle and skin-firming effect can be achieved.

The present invention relates to a method for monitoring effects of administration of a parathyroid hormone by determining levels of one or more markers of an activity of this hormone. Suitable markers of bone formation include one or more enzymes indicative of osteoblastic processes of bone formation, preferably bone specific alkaline phosphatase, and/or one or more products of collagen biosynthesis, preferably a procollagen I C-terminal propetide. Suitable markers of bone resorption and turnover include one or more products of collagen degradation, preferably an N-terminal telopeptide (NTX). In addition, methods for concurrently reducing the risk of both vertebral and non-vertebral bone fracture in a male human subject at risk of or having ossteoporosis are also disclosed, involving administration of human parathyroid hormone (amino acid sequence 1-34) without concurrent administration of an antiseropositive agent other than vitamin D or calcium.

The invention relates to the technical field of application of a cistanche phenylethanoid glycosides extract, and discloses the application of a cistanche phenylethanoid glycosides extract in preparing drugs for controlling hepatic fibrosis for the first time. The anti-hepatic fibrosis effect of the cistanche phenylethanoid glycosides extract is remarkable, activation and proliferation of hepatic stellate cells can be restrained, collagen synthesis can be reduced, collagen degradation can be promoted, the content of collagen in hepatic fibrosis tissue and the content of hydroxyproline in hepatic tissue can be reduced, and then synthesis of the extracellular matrix is restrained, the anti-hepatic fibrosis function is realized and a new direction is provided for controlling hepatic fibrosis diseases.

The present invention relates to methods and kits for evaluating the severity of a burn injury, which are based on the detection in a clinical fluid sample of skin metabolism products, such as collagen peptides which are released upon collagen degradation or synthesis.

The invention relates to a Chenopodiumformosanum Koidz (CFK) extract with anti-aging, whitening, anti-allergic and cell repair functions, which is to administer an effective dose of CFK extract to skin cells. The invention has mechanism functions of DPPH and ABTS +free radical removal ability, reducing power, chelation of iron ions and inhibition of lipid peroxide efficiency; inhibition of tyrosinase activity; removal of nitric oxide (NO) free radicals, and inhibition of lipoxygenase (LOX-1) activity; inhibition of hyaluronidase, increase in the hyaluronidase content of the skin, promotion ofwound repair, and reduction of the production of wrinkles; inhibition of the activity of matrix metalloproteinases (MMPs), and reduction of the degradation of collagen; and promotion of the ability of cell repair, enhancement of the anti-allergic ability and the like.

The invention relates to a longan flower extract with anti-aging, whitening, anti-allergic and cell repair functions, and the invention applies an effective dose of longan flower extract to skin cells, which has the functions of scavenging DPPH. and ABTS.+ free radicals, reducing power, chelation of iron ions and inhibiting lipid peroxide performance; inhibiting tyrosinase activity; removing nitric oxide (NO) free radicals, inhibition of lipoxygenase 1 (LOX-1) activity; inhibiting hyaluronic acid capacity, increase skin hyaluronic acid content, promoting wound repair, and reducing wrinkles production; inhibiting matrix metalloproteinases (MMPs) activity, and reducing collagen degradation; promoting cell repair ability and improving anti-allergic ability and other mechanisms.

The invention relates to a strain for producing high-efficiency collagenase and an application thereof. The strain is preserved in China Center for Type Culture Collection on October 9th, 2020, the preservation number is CCTCC M2020574, and the address is Wuhan University, Wuhan, China. The strain has collagen degradation capacity, and the produced collagenase can be applied to collagen degradation and collagen oligopeptide production. In particular, the strain has high degradation capability on collagen raw materials such as cattle bones, fish skin and the like and can be used for further enzymolysis treatment on meat processing and fishery processing byproducts such as the cattle bones and the fish skin, cod skin is adopted as a raw material, a peptide fragment with the molecular weightsmaller than 3000Da of the prepared collagen oligopeptide is more than 95%, the molecular weight is small, the uniformity is high, and the collagen is easy to absorb and utilize by a human body, effectively improves the added value of the collagen byproduct, and has good economic benefit.

Extracts of plants of the Ericacea family are administered to individuals to combat the signs of aging of the skin, e.g., wrinkles and fine lines, for example by inhibiting the expression of metalloproteases, by inhibiting collagen degradation, or by inhibiting UV-induced skin degradation.