64 results about "L-Carnosine" patented technology

A topical composition comprising a lipoic acid, a carnitine, and a carnosine in a suitable vehicle for topical application and a method for treating skin is provided. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles and loss of elasticity. Preferred components include R-lipoic acid or R-dihydrolipoic acid, acetyl-l-carnitine, and l-carnosine.

The invention discloses a method for preparing polaprezinc, and belongs to the technical field of pharmacy. The method comprises the following steps: 1, preparing a solution to 2-cyano acetyl chlorideand dichloromethane, dropwise adding the solution to a trimethylsilyl-protected dichloromethane solution of L-histidine, and adding imidazole to obtain (s)-2-cyanoacetamido-3-(1H-imidazole-4-yl)propionic acid; carrying out a catalytic hydrogenation reaction to obtain crude L-carnosine; carryin gout alkaline macro-porous ion exchange resin adsorption, flushing the adsorbed L-carnosine with an aqueous solution of alkali metal acetate, and carrying out spray drying to obtain an alkali metal salt solid of the L-carnosine; and dissolving the alkali metal salt solid of the L-carnosine in methanol,adding a methanol solution of zinc acetate, and beating and refining the obtained solution by using a methanol-water solution to obtain refined polaprezinc. The method allows highly-pure L-carnosine sodium and polaprezinc to be obtained, and allows the time of the refining and drying process of the polaprezinc to be short, and the refined polaprezinc has the advantages of easiness in crushing, high yield and low cost, so the method is suitable for industrial production.

Disclosed herein is a composition comprising a liposome, a cardiolipin, and at least one antioxidant, wherein the composition is useful for improving, maintaining, or restoring a mitochondrial membrane and / or mitochondrial function. In one example, the liposome is primarily composed of phosphatidylcholine, the cardiolipin is tetraoleoyl-cardiolipin, and the at least one antioxidant is methylgentisate, l-carnosine, or both. The composition may be topically administered, orally administered, or parenterally administered, for example administered by injection. If topically administered, the composition may be administered for example, as a cream, lotion, gel, paste, spray, tonic, or other suitable form and may contain various additives, for example, one or more of an emollient, a humectant, a penetration enhancer, a vitamin, a fragrance, a pigment, and a moisturizer.

The invention discloses a method of synthesizing L-carnosine using L-amino acid ligase by a one-step method. The method comprises the steps of taking beta-alanine, L-histidine, ATP (adenosine triphosphate) and polyphosphate as raw materials, and MgCl2 as an activator, adding L-amino acid ligase and polyphosphate kinase, and synthesizing L-carnosine through an enzymatic reaction and coupled coupleunder conditions of a pH of 6.5-8.5 and a temperature of 30-45 DEG C. According to the method, a sequence optimized L-amino acid ligase gene is successfully expressed in escherichia coli, and beta alanine and L-histidine can be catalyzed to synthesize L-carnosine at one step. A substrate is not required to be methylated or subjected to group protection; ATP required by a catalytic reaction is continuously regenerated by allowing polyphosphate kinase to catalyze phosphorylation of ADP (adenosine diphosphate); cyclic regeneration of ATP can be achieved only by consuming a small amount of ADP; and a renewable raw material, sodium hexametaphosphate, is wide in source, low in cost, simple to operate and easy in large-scale production.

The invention discloses a preparation method of non-hydrazine L-carnosine, and belongs to the technical field of organic synthesis. The method comprises the following steps: reacting anhydrous o-benzoyl diformyl-L-carnosine with 5-10 times of weight of low fat serotonin at the temperature of 20-35 DEG C for 8-12 hours to remove a protecting group; and after reaction is finished, distilling to remove the low fat serotonin, adding a crystallization solvent for crystallization, and filtering, washing and drying to obtain the product, wherein the low fat serotonin is alkyl primary amine of C3-C8.The method has the advantages that the cost is low, energy consumption is also low, the operability is high, the obtained product L-carnosine does not contain toxic substance hydrazine, and thus, thesafety of the L-carnosine is fully guaranteed.

The invention relates to a preparation method of L-carnosine. According to the invention, phthaloyl-L-carnosine and organic amine are heated in a solvent, such that protective groups are removed and a product is precipitated; filtering, solvent washing, and drying are carried out, such that an L-carnosine product is obtained; or concentration, crystallization, filtering and drying are carried out, such that a hydrazine-free L-carnosine product is obtained. The method provided by the invention has the advantages of simple method, low cost, and high operability. No toxic compound hydrazine exists in the obtained carnosine product. The quality of the obtained product can be sufficiently ensured, and the health safety of the product is shown.