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Composite solution of sodium hyaluronate and application of composite solution for reducing skin wrinkle

A sodium hyaluronate and compound technology, applied in prosthetics, medical science, etc., can solve the problems of easy formation of cords, short half-life, and aesthetic impact, achieving no obvious complications, increased degradation time, and high safety Effect

Inactive Publication Date: 2016-12-14
IMEIK TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The epidermis of the neck skin is thin, and it is difficult to press and massage after injection of cross-linked sodium hyaluronate, which is easy to form unevenness; in addition, the subcutaneous is the platysma muscle, if the injection layer is inappropriate in the muscle layer, it is easy to form a sense of thread
The occurrence of the above situations will seriously affect the appearance and lose the therapeutic effect, so cross-linked sodium hyaluronate is not suitable for neck lines correction
[0005] Non-cross-linked sodium hyaluronate does not have the above-mentioned side effects of cross-linked sodium hyaluronate, but under the action of free radicals and hyaluronidase, non-cross-linked sodium hyaluronate has a short half-life in the skin and is easily degraded

Method used

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  • Composite solution of sodium hyaluronate and application of composite solution for reducing skin wrinkle
  • Composite solution of sodium hyaluronate and application of composite solution for reducing skin wrinkle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Compared with the pure sodium hyaluronate solution, the compound solution can effectively resist the degradation of free radicals.

[0022] Sample preparation

[0023] Compound solution: Prepare 5.000 mg / mL sodium hyaluronate, 2.000 mg / mL L-carnosine, 0.100 mg / mL glycine, 0.200 mg / mL proline, 0.100 mg / mL alanine and 0.005 mg / mL vitamin B2 Solution; adjust the pH value to 7.2 after each component is completely dissolved during preparation.

[0024] Pure sodium hyaluronate solution: prepare 5.000 mg / mL sodium hyaluronate; adjust the pH value to 7.2 after it is completely dissolved during preparation.

[0025] Experimental materials: copper sulfate pentahydrate, 30% hydrogen peroxide, sodium hyaluronate, L-carnosine, glycine, alanine, proline, vitamin B2, 1M hydrochloric acid, bovine serum, potassium acetate, glacial acetic acid, sodium chloride, purified water.

[0026] experimental method:

[0027] Take 1.0mL sodium hyaluronate solution, 1.0mL sodium hya...

Embodiment 2

[0037] Example 2: The compound solution has a longer degradation cycle than pure sodium hyaluronate solution

[0038] Sample preparation:

[0039] Compound solution: Prepare 5.000 mg / mL sodium hyaluronate, 2.000 mg / mL L-carnosine, 0.100 mg / mL glycine, 0.200 mg / mL proline, 0.100 mg / mL alanine and 0.005 mg / mL vitamin B2 Solution; after each component is completely dissolved during preparation, adjust the pH value to 7.2, filter and sterilize through a 0.2 μm filter, and then use it for animal experiments.

[0040] Pure sodium hyaluronate solution: Prepare 7.400 mg / mL sodium hyaluronate solution; adjust the pH value to 7.2 after the components are dissolved during preparation, and filter and sterilize with a 0.2 μm filter before using in animal experiments.

[0041] Experimental animals: BALB / c mice aged 7-8 months.

[0042] experimental method:

[0043] The 48 mice were randomly divided into 4 groups, 12 in each group, which were the test group 7 days after injection, the tes...

Embodiment example 3

[0046] Implementation Case 3: The compound solution has a better neckline filling effect than pure sodium hyaluronate solution

[0047] In order to evaluate the effectiveness of the compound solution, we conducted a trial in patients with neck wrinkles to evaluate the clinical power and safety.

[0048] Clinical method:

[0049] Injection method: Use a 30G×1 / 2 needle, tighten the skin at the neck lines when injecting, select multiple points, insert the sample into the dermis along the direction of the neck lines, inject while withdrawing the needle, and inject a small amount to form a skin mound.

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Abstract

The invention relates to a composite solution of sodium hyaluronate and application of the composite solution for reducing skin wrinkles. The composite solution comprises sodium hyaluronate, L-carnosine, amino acid and a water soluble vitamin as main components, including 1.000 to 5.000mg / mL of sodium hyaluronate, 1.000 to 2.000mg / mL of L-carnosine, 0.100 to 0.500mg / mL of amino acid and 0.001 to 0.005mg / mL of water soluble vitamin B2, and the pH value of the composite solution is 7 to 7.2. By adopting the composite solution, extracellular matrixes can be compensated to skin, synthesis of skin collagen protein can be promoted, and a function of reducing wrinkles can be achieved. Clinical tests on the composite solution show that the composite solution can be used for reducing winkles, and is good in safety and free of conspicuous complication.

Description

technical field [0001] The invention relates to a compound solution of sodium hyaluronate and its application for correcting skin wrinkles. It is a compound solution mainly composed of sodium hyaluronate, L-carnosine, amino acids and water-soluble vitamins. This product can replenish extracellular matrix to the skin, promote the synthesis of skin collagen, and correct wrinkles. Background technique [0002] With the influence of aging and photoaging, hyaluronic acid, chondroitin sulfate, collagen, etc. in the dermis are gradually lost, and the skin loses its elasticity. In this process, the aging of the neck is particularly serious, and some horizontal wrinkles will be produced. The reason is that the thickness of the neck skin is only 2 / 3 of that of the face, where the sebaceous glands and sweat glands are the fewest, and the collagen content is low, and the subcutaneous fat layer is thin. [0003] The extracellular matrix of the skin contains a variety of polymer polysac...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/50A61L27/20
CPCA61L27/20A61L27/50A61L27/54A61L2300/214A61L2300/428A61L2300/802C08L5/08
Inventor 简军陈雄伟
Owner IMEIK TECH DEV CO LTD
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