Injection Cu(DDC)2 protein nano-particle preparation used for treating tumor, and preparation method thereof
A nanoparticle and injection technology, applied in the field of pharmaceutical preparations, can solve the problems of poor water solubility, less toxic and side effects, and achieve the effects of less discomfort, high safety, and less hospitalization time.
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Embodiment 1
[0046]3mg Cu(DDC) 2 Dissolve in 3mL of dichloromethane, add to 36.0mL human serum albumin double distilled water solution (1%w / v) under stirring, stir in ice bath for 10min, ultrasonicate for 9min under the condition of ultrasonic power 300W (3s / 1s), 25℃ Dichloromethane was removed by rotary evaporation under reduced pressure to obtain Cu(DDC) 2 Albumin nanoparticles, the particle size range is 120nm-160nm. The obtained Cu(DDC) 2 Nanoparticle TEM see figure 1 .
Embodiment 2
[0048] 3mg Cu(DDC) 2 Dissolve in 3 mL of chloroform, add to 30.0 mL of human serum albumin double-distilled aqueous solution (1% w / v) under stirring, stir in ice bath for 10 min, ultrasonicate for 9 min under the condition of ultrasonic power 300W (3s / 1s), 50℃ Remove chloroform by rotary evaporation under reduced pressure to obtain Cu(DDC) 2 Albumin nanoparticles, the particle size range is 120nm-160nm. Trehalose was added as a lyoprotectant.
Embodiment 3
[0050] 3mg Cu(DDC) 2 Dissolve in 3mL acetone, add to 24.0mL human serum albumin double distilled water solution (1%w / v) under stirring, stir in ice bath for 10min, ultrasonicate for 9min under the condition of ultrasonic power 300W (3s / 1s), decompress at 45℃ Acetone was removed by rotary evaporation to obtain Cu(DDC) 2 Albumin nanoparticles, the particle size range is 120nm-160nm.
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