Quick-releasing tablet in vagina and its preparing method
An immediate-release tablet and vaginal technology, which is applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, pill delivery, etc., to achieve the effects of less discomfort, simple and practical preparation method, and accurate medication
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Embodiment approach 1
[0036] For misoprostol vaginal immediate-release tablets, the weight of each component per 1000 tablets is:
[0037] Misoprostol dispersion 2.5g (converted to pure misoprostol 25mg)
[0038] Mannitol 94g
[0039] Microcrystalline Cellulose 40g
[0040] Croscarmellose Sodium 6g
[0041] pvp K30 4g
[0042] Magnesium Stearate 4g
[0043] The preparation method of misoprostol vaginal immediate release tablet is:
[0044] Step 1. Grinding and sieving: Grinding and sieving the above-mentioned drugs and auxiliary materials respectively, and the particle size of the fine powder is about 50 μm.
[0045] Step 2. mixing: take misoprostol dispersion and pharmaceutical adjuvant fine powder by prescription quantity, 2 / 3 disintegrant wherein and whole lubricant fine powder are reserved for subsequent use, then principal agent fine powder and the rest The fine powder of auxiliary materials is mixed evenly.
[0046] Step 3. Granulation: with 7.5% PVP K30 Appropriate am...
Embodiment approach 2
[0052] For levofloxacin vaginal immediate-release tablets, the weight of each component per 1000 tablets is:
[0053] Levofloxacin 100g
[0054] Mannitol 39g
[0055] Gelatin 10g
[0056] PEG6000 6g
[0057] The preparation method of levofloxacin vaginal immediate release tablet comprises:
[0058] Step 1. Dosing: crush and sieve levofloxacin to obtain a fine powder with a particle size of 50 μm. Take 700ml of pure water, add the prescribed amount of gelatin, heat to 60°C and stir to dissolve, add mannitol and PEG6000 to dissolve, and cool to room temperature. Then add levofloxacin fine powder, stir to form a suspension, add pure water to 750ml. If necessary, a suitable pharmaceutically acceptable surfactant is added to make a stable suspension.
[0059] Step 2. Dispensing of the medicinal solution: Quantitatively dispense the above medicinal solution into the PVC multiple depression models, 0.75ml for each depression model.
[0060] Step 3. Freeze-drying: put the PVC m...
Embodiment approach 3
[0066] Azithromycin vaginal immediate-release tablets, the weight of each component per 1000 tablets is:
[0067] Azithromycin 25g
[0068] Lactose 30g
[0069] Microcrystalline Cellulose 15g
[0070] Crospovidone 4.5g
[0071] pvp K30 3g
[0072] Magnesium Stearate 3g
[0073] The preparation method of the azithromycin vaginal immediate release tablet is the same as that of embodiment 1.
[0074] Tablet weight 800mg hardness 2.0kg / cm 2
[0075] Determination of disintegration time limit: according to Chinese Pharmacopoeia 2000 edition, Chlorophytum improved method, measured disintegration time limit, disintegrated within 45 seconds; animal experiment: disintegrated within 60 seconds.
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