The invention relates to a method for preparing a microencapsulated drink of a Nanguo pear liver-protecting anti-alcohol agent, which is particularly used for Nanguo pear fruit and provides a theoretical basis for quantification of ethanol and acetaldehyde dehydrogenase in Nanguo pear liver-protecting anti-alcohol drink production. The process of the method comprises: raw material selection, washing, block cutting, water-bath soakage, ice-bath grinding, ice-bath homogenization, one-hour 0 to 4 DEG C extraction, 15-minute 400-rpm centrifugation, freezing concentration, the preparation of enteric microencapsulates of mixed concentrates of the ethanol, the acetaldehyde dehydrogenase and the like and the preparation of the drink by blending according to required package. The preparation of enteric microencapsulates of the mixed concentrates of the ethanol, the acetaldehyde dehydrogenase and the like is implemented by the following steps: mixing a wet enzyme paste mixture and 10 percent gelatin and 5 percent xanthan gum in a volume ratio of 1:5.5; fully and uniformly mixing the materials; uniformly mixing the mixed materials with a certain amount of 2-percent sodium alga acid; injecting the mixed solution into cooled solution of CaCl2 by using a glass syringe with a No.4 syringe needle to perform emulsification for 10 minutes with a stirring speed or 400rpm to obtain colloid-calcium alginate double-layer gel beads; subjecting the colloid-calcium alginate double-layer gel beads to a film forming reaction with solution of chitosan for 30 minutes; removing unreacted chitosan by washing to obtain wet Nanguo pear-dehydrogenase combined microencapsulate gel beads; and placing the microencapsulated dehydrogenase microencapsulate gel beads in a regulation tank for regulating concentration according to an anti-alcohol ratio, adding a proper amount of sugar and other seasoning matters, homogenizing the mixture, and automatically filling and sealing the resulting product.