Preparation method and application of PHBV/rosiglitazone (RSG) sustained-release membrane

A slow-release film and solution technology, applied in the field of medicine, can solve the problems of short duration of drug action and achieve the effect of less side effects

Inactive Publication Date: 2018-11-06
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although rosiglitazone formulated as eye drops with a concentration of 0.5% or subconjunctival injection has definite anti-scar effect and few side effects, the action time of the drug is short and repeated medication is required

Method used

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  • Preparation method and application of PHBV/rosiglitazone (RSG) sustained-release membrane
  • Preparation method and application of PHBV/rosiglitazone (RSG) sustained-release membrane
  • Preparation method and application of PHBV/rosiglitazone (RSG) sustained-release membrane

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Experimental program
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Embodiment Construction

[0030] The technical solutions of the present invention will be further described in detail below in conjunction with specific embodiments.

[0031] Rosiglitazone / PHBV release, degradation, in vivo experiments:

[0032] In the in vivo experiment, the rosiglitazone / PHBV membrane was placed on the surgical site, that is, under the conjunctiva, and its anti-scar effect was observed.

[0033] like figure 1 Rosiglitazone / PHBV membranes are shown. figure 2 It is the photomicrograph of rosiglitazone / PHBV film after electrospinning.

[0034] The present invention will be further described below in conjunction with specific analysis.

[0035] 1. Preparation of different concentrations of rosiglitazone / PHBV sustained-release films

[0036] Using the electrospinning method, adjust the spinning voltage, the advancing speed of the syringe pump, the distance between the syringe needle and the receiving plate, the ambient temperature, and the humidity, to prepare rosiglitazone / PHBV slow...

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Abstract

The invention discloses a preparation method and application of a PHBV / rosiglitazone (RSG) sustained-release membrane and belongs to the technical field of medicines. The preparation method comprisesthe following steps: mixing PHBV powder, chloroform and dimethylformamide and preparing a PHBV-TCM / DMF spinning solution with a mass percentage of 5 percent for later use; dissolving rosiglitazone ina dimethyl sulfoxide solution and preparing RSG / DMSO solutions with different concentration gradients; then adding in the spinning solution, preparing spinning solutions with different final concentrations and transferring into a glass syringe for electrostatic spinning to form the rosiglitazone / PHBV sustained-release membrane; the rosiglitazone / PHBV sustained-release membrane is used in the anti-glaucoma filtration operation, is safe, effective and lasting in anti-glaucoma postoperative scar formation and improves the long-term the glaucoma operation success rate, thereby having a very important clinical significance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method and application of a PHBV / rosiglitazone sustained-release film. Background technique [0002] Glaucoma is a neurodegenerative disease characterized by progressive vision loss and visual field defect. It is the leading cause of irreversible blindness worldwide and one of the preventable and controllable blinding eye diseases. The ultimate goal of glaucoma treatment is to control intraocular pressure and protect the optic nerve. The method of controlling intraocular pressure mainly contains medicine, laser, surgical treatment. Surgical treatment is glaucoma filtration surgery (GFS), which is also the main method for the treatment of glaucoma today. However, the excessive proliferation of Tenon's capsule fibroblasts (human tenon's fibroblasts, HTFs) after surgery leads to scarring of the filtration tract, making The 1-year failure rate after GFS is as high as 1...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/34A61K31/4439A61P27/06A61P27/02
CPCA61K9/0048A61K9/7007A61K31/4439A61K47/34A61P27/02A61P27/06
Inventor 段宣初刘海蓉张凤黄宇婷刘可潘政
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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