The present invention discloses a method for obtaining sensitivity coefficients of an effective multiplication factor to a section under different burnups. The method comprises: 1, performing forward
burnup calculation: first, using a subgroup method to calculate an effective self-shielding section of each
nuclide, second, using a modular characteristic line method to solve a
neutron angle flux density and a
neutron conjugate angle flux density, and third, using a chebyshev rational approximation method to calculate a
nuclear density of each
nuclide; 2, performing conjugate
burnup calculation: first, using the chebyshev rational approximation method to calculate an initial conjugate
nuclear density of each
nuclide, and then calculating a conjugate power, second, using the modular characteristic line method to calculate a generalized
neutron transport angle flux and a generalized conjugate
neutron transport angle flux, and third, calculating a conjugate initial
nuclear density of each nuclide of a next step; and 3, calculating sensitivity coefficients of the section of each nuclide to an effective multiplication factor under different burnups. The method provided by the present invention solves a defect of the existing method that sensitivity coefficients of an effective multiplication factor to a nuclear section under different burnups cannot be accurately and effectively calculated.