407results about How to "Minimize contamination" patented technology

A flexible mounting base to hold a sensor at an infusion site, the sensor being a removable in vivo sensor for monitoring analyte concentration level in a patient, such as blood glucose (BG) level. The mounting base comprises a flexible adhesive that anchors the flexible sensor set at an infusion site to provide stability for the sensor set in a convenient and comfortable manner. Placement of the mounting base onto the patient's skin causes the insertion needle to pierce the skin for transcutaneous placement of the cannula with the sensor therein. The insertion needle can then be withdrawn to leave the cannula and sensor at the selected insertion position, with the distal segment of the sensor being exposed to patient extracellular fluid via apertures formed in the cannula.

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.

Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analysis include nucleic acid amplification and detection and immuno-PCR.

This invention comprises an improved electroporation electrode system comprising a single needle and a ring or donut shaped electrode wherein the difference in surface area of the electrodes provide for a substantial reduction of current density near the surface of the treated tissue and a more concentrated current density sufficient for electroporation only in tissues adjacent to the terminal portion of the single needle electrode. Thus, this invention provides for targeting specific tissue for electroporation and also should provide for lessening the sensation of electric current in the treated tissue.

A railcar with discharge control system is disclosed. In one embodiment, a railway car includes an underframe and at least one hopper for transporting lading. The railway car further including the underframe including a center sill which defines in part a longitudinal axis of the railway car. A discharge opening formed proximate to a lower portion of the hopper. A respective door assembly pivotally mounted adjacent to the discharge opening to control the flow of lading from the hopper. The door assembly operable for movement between a first, closed position and a second, open position relative to the discharge opening. A discharge control system operable to move the door assembly between the first position and the second position. The discharge control system operably moves generally longitudinally along the axis of the railway car to move the door assemblies between the first, closed position and the second, open position.

Thermal spray processing and cold spray processing are utilized to manufacture porous starting materials (such as tube stock, wire and substrate sheets) from biocompatible metals, metal alloys, ceramics and polymers that may be further processed into porous medical devices, such as stents. The spray processes are also used to form porous coatings on consolidated biocompatible medical devices. The porous substrates and coatings may be used as a reservoir to hold a drug or therapeutic agent for elution in the body. The spray-formed porous substrates and coatings may be functionally graded to allow direct control of drug elution without an additional polymer topcoat. The spray processes are also used to apply the drug or agent to the porous substrate or coating when drug or agent is robust enough to withstand the temperatures and velocities of the spray process with minimal degradation.

This invention relates to novel transdermal or transmucosal pharmaceutical formulation which reduces the occurrences of contamination of other individuals and the transference to clothing of the user. The novel formulation includes at least one pharmacologically active ingredient, and a solvent system having a monoalkylether of diethylene glycol and a glycol present in specified ratios, and a mixture of water and alcohol. The invention also relates to a method for inhibiting or delaying crystallization of an active agent in a pharmaceutical formulation.

A method for vaporizing organic material and condensing it onto a surface to form a layer, comprising: providing a quantity of first organic material in a powdered form in a first container and a quantity of second organic material in a second container spaced from the first container; fluidizing the first organic material in the first container, transferring the fluidized first organic material from the first container into a manifold, and vaporizing the first organic material in the manifold; fluidizing the second organic material in the second container, transferring the fluidized second organic material from the second container into the manifold, and vaporizing the second organic material in the manifold where the first and second vaporized organic materials are mixed; and delivering from the manifold the mixed vaporized materials to the substrate surface to form the layer.

A method for vaporizing organic materials onto a surface, to form a film includes providing a quantity of organic material in a fluidized powdered form; metering the powdered organic material and directing a stream of such fluidized powder onto a first member; heating the first member so that as the stream of fluidized powder is vaporized; collecting the vaporized organic material in a manifold; and providing a second member formed with at least one aperture in communication with the manifold that permits the vaporized organic material to be directed onto the surface to form a film.

A method for vaporizing organic materials and condensing them onto a surface to form a layer, comprising: providing a quantity of organic material in a powdered form in a first container; fluidizing the organic material in the first container and transferring such fluidized material to an auger structure; and rotating at least a portion of the auger structure to transfer fluidized powder from the first container along a feeding path to a vaporization zone where such powder is vaporized and delivered to the substrate to form the layer.

An etching apparatus for manufacturing semiconductor devices which reduces contamination of the processing surface of a wafer by transporting a plurality of wafers stacked in a cassette with their processing surfaces facing down from the cassette supply chamber to one or more process chambers where the etching operation is performed on each wafer, one at a time. The apparatus has a load lock chamber for transferring the wafers stacked in the cassette from the cassette supply chamber, which is maintained under atmospheric conditions, to the process chamber, which is maintained under a strong vacuum. The process chamber has a cathode to which a wafer is clamped by a wafer holder with its processing surface facing down; the process chamber may also have a removable lower cover for easy repair and cleaning. The apparatus may also have a wafer aligning chamber installed between the cassette supply chamber and the load lock chamber for simultaneously aligning all of the wafers n the cassette before they are transported to the load lock chamber. The wafer aligning chamber also has a cassette transport mechanism for transferring the cassette from a cassette supply table in the cassette supply chamber to an elevator installed in the load lock chamber.

An implantable device is provided for controlling hemorrhage in a body cavity, comprising an expandable balloon and a conduit for supplying a physiologically compatible fluid to inflate the balloon. When the balloon tamponade device is implanted or inserted into the body cavity, it is inflated with a physiologically suitable fluid, so that the balloon generally conforms to the body cavity and exerts compressive force against the walls, tissues or structures of the body cavity to control hemorrhage. The balloon may have a deforming means to limit expansion of the balloon in a direction to facilitate expansion of the balloon in another direction. The device may have additional tubes within the conduit, or a plurality of separate lumens within the conduit or tubes to allow drainage and irrigation to the body cavity. There is also provided a cuff for attachment of an external traction to the balloon tamponade, to facilitate the compressive effect of the device. In a preferred embodiment, there is provided a dual balloon tamponade in which two balloons are axially spaced along the conduit, providing a means to control hemorrhage from two distinct body cavities, such as a uterus and a vagina. There is also provided a method to control hemorrhage in a body cavity by implantation or insertion of the balloon tamponade, inflating the balloon with a fluid to a sufficient pressure and retaining the fluid pressure within the balloon for a sufficient period of time to determine whether hemorrhage has been controlled. A kit comprising the balloon tamponade apparatus is also provided.

Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include high density nucleic acid amplification and detection and immuno-PCR.

A device and method for preventing an occlusion of a catheter including a catheter adapter and a catheter where a flexured portion of the catheter is supported by a bending surface of the catheter adapter. The flexured portion of the catheter may also include a maximum insertion length mark and / or a flexible support member to support and strengthen the flexured portion of the catheter against occlusions. A bending surface is provided over which a flexured portion of the catheter may gently bend to accommodate the transition of the catheter from the catheter adapter to the insertion site without occluding the catheter.

A window for a radiation detection system includes a frame with an aperture therein configured to receive radiation therethrough. A plurality of silicon ribs span the aperture and are carried by the frame. A coating substantially envelopes each of the plurality of silicon ribs. A thin film covers the aperture and is carried by the plurality of silicon ribs and is configured to pass radiation therethrough.