393 results about "Structure function" patented technology

Implantable devices and methods for the repair of a defective cardiac valve are provided. The implantable devices include an annuloplasty ring and a restraining or support structure or mechanism. The annuloplasty ring functions to reestablish the normal size and shape of the annulus bringing the leaflet in proximity to each other. The restraining structure functions to restrain the abnormal motion of at least a portion of the valve being repaired. The restraining structure may include at least one restraining member across the interior of the circumference of the ring in a configuration consisting of a primary member to which secondary members are attached or one where all members traverse the ring. Kits for using the devices and practicing the methods of the invention are also provided.

A heart rate measuring device is attached around a user's hand, the device having an inner surface, which is in contact with the skin on the hand to which it is attached, and an outer surface, which is other than the inner surface. The inner surface of the measuring device is provided with an electrically conductive inner structure, which functions as an electrode for a contact with the skin of the hand to which the device is attached. An electrically conductive outer structure functions as an electrode for a contact with the user's other hand and it is electrically isolated from the electrically conductive inner structure. The electrically conductive outer structure on the measuring device extends at least to opposite sides of the hand to which the device is attached, and at least part of the electrically conductive outer surface is on the outer surface of the measuring device, on opposite sides of the hand to which the device is attached. The electrically conductive outer structure and inner structure are connected to a measuring unit for heart rate measurement.

Implantable devices and methods for the repair of a defective cardiac valve are provided. The implantable devices include an annuloplasty ring and a restraining and / or a remodeling structure or mechanism. The annuloplasty ring functions to reestablish the normal size and shape of the annulus bringing the leaflet in proximity to each other. A device having a remodeling structure further facilitates remodeling of the valve but allows the use of a flexible ring. The restraining structure functions to restrain the abnormal motion of at least a portion of the valve being repaired. The restraining and remodeling structures may include at least one strut across the interior of the circumference of the ring.

Methods for determining transcription rate of mRNA in eukaryotic cells using nuclear runoff transcription where labeled RNA molecules are hybridized against an array of at least 500 nucleic acid molecule probes representing at least part of the genome of the native eukaryotic organism to identify the quantity of nascent mRNA transcripts in said cells. The method can be used to simultaneously identify the quantity of a large number of mRNA transcripts. A rate of degradation for distinct mRNA in a eukaryotic cell rate is determined by comparing a steady state mRNA with nuclear runoff mRNA. Steady state to nuclear runoff ratios are used to determine gene and mRNA structure function relations that leads to gene expression and mRNA stability, predict structural determinants for mRNA stability and predict regulatory motifs for transcription rates. Methods of constructing recombinant organisms with enhanced stability for mRNA expressed from a gene of interest comprise introducing into the genome of an organism a gene containing one or more sequence elements that confer structural stability on mRNA transcribed from said gene.

A method of forming a thinned encapsulated chip structure, wherein the method comprises providing a separation structure arranged within an electronic chip, encapsulating part of the electronic chip by an encapsulating structure, and thinning selectively the electronic chip partially encapsulated by the encapsulating structure so that the encapsulating structure remains with a larger thickness than the thinned electronic chip, wherein the separation structure functions as a thinning stop.

A vertical field effect transistor includes: an active region with a bundle of linear structures functioning as a channel region where electric carriers are transported; a lower electrode, connected to the bottom of the active region and functioning as one of source and drain regions; an upper electrode, connected to the top of the active region and functioning as the other of the source and drain regions; a gate electrode for controlling the electric conductivity of at least a portion of the bundle of linear structures included in the active region; and a gate insulating film arranged between the active region and the gate electrode to electrically isolate the gate electrode from the bundle of linear structures. The transistor further includes a dielectric portion between the upper and lower electrodes. The upper electrode is located over the lower electrode with the dielectric portion interposed and includes an overhanging portion that sticks out laterally from over the dielectric portion. The active region is located right under the overhanging portion of the upper electrode.

A method for predicating surface roughness and surface topography simulation of a car milling compound machining comprises the following six steps: step one, a modeling of a unified cutter position coordinate model of a whole cutter and an inserted blade cutter; step two, a modeling of the geometrical movement trace of a milling cutter cutting edge; step three, a consideration of influences of the vibration of the cutters to a workpiece surface morphology; step four, a microscopic surface morphology representation method; step five, a car milling compound machining basic structure function; step six, a simulation algorithm example and an orthogonal test method. The method combines the geometrical simulation and the physical simulation together, static and dynamic deformations which are produced when cutters cut under stress are fully considered, models for general car milling compound machining method of any angle are theoretically built, and a surface method of the roughness calculation of the car milling compound machining is deduced. The method for predicating surface roughness and surface topography simulation of the car milling compound machining has good practical values and broad application prospects in the technical field of machinery manufacturing processing.

A vertical field effect transistor includes: an active region with a bundle of linear structures functioning as a channel region; a lower electrode, functioning as one of source and drain regions; an upper electrode, functioning as the other of the source and drain regions; a gate electrode for controlling the electric conductivity of at least a portion of the bundle of linear structures included in the active region; and a gate insulating film arranged between the active region and the gate electrode to electrically isolate the gate electrode from the bundle of linear structures. The transistor further includes a dielectric portion between the upper and lower electrodes. The upper electrode is located over the lower electrode with the dielectric portion interposed and includes an overhanging portion sticking out laterally from over the dielectric portion. The active region is located right under the overhanging portion of the upper electrode.

Provided are napthoquinone-type compounds which can be used to modulate the aggregation of protein (e.g. tau) associated with neurodegenerative disease (e.g. Alzheimer's disease). Structure-function characteristics for oxidised and reduced napthoquinone-type compounds, such as menadione-related compounds, are disclosed. The invention further provides methods of treatment or prophylaxis of neurodegenerative diseases and / or clinical dementias based on the compounds.

The invention relates to a population distribution spatial-temporal evolution and cognition method considering urban pattern characteristics. The population distribution spatial-temporal evolution andcognition method comprises the following steps: 1) carrying out scale conversion of multi-source and multi-scale remote sensing images; 2) extracting urban information based on the multi-source remote sensing image; 3) analyzing a multi-scale urban pattern-structure-function spatial-temporal relationship; 4) carrying out spatial-temporal correlation and coupling analysis on population distribution and urban characteristics; 5) constructing a population distribution simulation and prediction system considering urban pattern characteristics; and 6) carrying out spatial-temporal monitoring and cognition on population distribution in different scenes. The population distribution spatial-temporal evolution and cognition method has the advantages that population general survey and statistical data, multi-scale remote sensing data and multi-source land utilization / coverage data are used as data sources; the spatial-temporal characteristics and the evolution rule of the multi-scale urban spatial pattern are studied, and the population distribution spatial-temporal evolution model considering the town characteristic pattern is constructed, and the boundary of the population distribution density is finely described from the multi-level spatial scale, and a theoretical basis and a technical support are provided for population resource utilization and policy adjustment and social and economic resource allocation.